SHIMANO Hitoshi

Researcher's full information

Articles
  • 小児, 思春期の糖尿病
    島野 仁
    思春期学 = ADOLESCENTOLOGY/23(1)/p.45, 2005-03
  • Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells
    Takahashi A; Motomura K; Kato T; Yoshikawa T; Nakagawa Y...
    DIABETES/54(2)/pp.492-499, 2005-02
  • Receptor-Type Protein Tyrosine Phosphatase ε(PTPεM) is a Negative Regulator of Insulin Signaling in Primary Hepatocytes and Liver(Cell Biology)
    Nakagawa Y; Aoki N; Aoyama K; Shimizu H; Shimano H; Yamada N; M...
    Zoological science/22(2)/pp.169-175, 2005-02
  • Microarray analyses of SREBP-1 target genes.
    Yahagi N; Shimano H
    In Berger A and Roberts MA (ed.), Unraveling Lipid Metabolism with Microarrays/p.237-248, 2005-01
  • Lipid Metabolism and Inflammation
    島野 仁
    ホルモンと臨牀/52(12)/pp.1145-1151, 2004-12
  • Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide
    Tamura Y; Osuga J; Adachi H; Tozawa R; Takanezawa Y; Ohas...
    JOURNAL OF BIOLOGICAL CHEMISTRY/279(30)/pp.30938-30944, 2004-07
  • P53 involvement in the pathogenesis of fatty liver disease
    Yahagi N; Shimano H; Matsuzaka T; Sekiya M; Najima Y; Oka...
    JOURNAL OF BIOLOGICAL CHEMISTRY/279(20)/pp.20571-20575, 2004-05
  • Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages
    Sone H; Shimano H; Shu M; Nakakuki M; Takahashi A; Sakai ...
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS/316(3)/pp.790-794, 2004-04
  • Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice
    Matsuzaka T; Shimano H; Yahagi N; Amemiya-Kudo M; Okazaki...
    DIABETES/53(3)/pp.560-569, 2004-03
  • WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney.
    Wang Y; Suzuki H; Yokoo T; Tada-Iida K; Kihara R; Miura M; Wata...
    Biochemical and biophysical research communications/324(3)/pp.1053-1058, 2004-01
  • Lipid synthetic transcription factors SREBPs suppress IRS-2-mediated insulin signaling in the liver.
    Ide T; Shimano H.; Yahagi N; Matsuzaka T; Nakakuki M...
    Nature Cell Biology/6/p.351-7, 2004-01
  • Insulin-independent induction of SREBP-1c expression in the livers of streptozotocin-treated mice.
    Matsuzaka T; Shimano H.; Yahagi N; Amemiya-Kudo M; Okazak...
    Diabetes/53/p.560-9, 2004-01
  • P57(Kip2) regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus
    Yokoo T; Toyoshima H; Miura M; Wang YH; Iida KT; Suzuki ...
    JOURNAL OF BIOLOGICAL CHEMISTRY/278(52)/pp.52919-52923, 2003-12
  • Physiological changes in circulating mannose levels in normal, glucose-intolerant, and diabetic subjects
    Sone H; Shimano H; Ebinuma H; Takahashi A; Yano Y; Iida ...
    Metabolism/52(8)/pp.1019-1027, 2003-01
  • FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products.
    Tamura Y; Adachi H; Osuga J; Ohashi K; Yahagi N; Sekiya ...
    J Biol Chem/278/p.12613-7, 2003-01
  • Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats.
    Iida KT; Kawakami Y; Suzuki M; Shimano H.; Toyoshima H; S...
    Am J Physiol Endocrinol Metab/284/p.E1125-30, 2003-01
  • Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.
    Yoshikawa T; Ide T; Shimano H.; Yahagi N; Amemiya-Kudo M...
    Mol Endocrinol/17/p.1240-54, 2003-01
  • Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.
    Ide T; Shimano H.; Yoshikawa T; Yahagi N; Amemiya-Kudo M...
    Mol Endocrinol/17/p.1255-67, 2003-01
  • p53 Activation in adipocytes of obese mice.
    Yahagi N; Shimano H.; Matsuzaka T; Najima Y; Sekiya M; Na...
    J Biol Chem/278/p.25395-400, 2003-01
  • Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.
    Ono H; Shimano H.; Katagiri H; Yahagi N; Sakoda H; Onishi...
    Diabetes/52/p.2905-13, 2003-01
  • Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter.
    Kajihara M; Sone H; Amemiya M; Katoh Y; Isogai M; Shimano...
    Biochem Biophys Res Commun/312/p.831-42, 2003-01
  • Polyunsaturated fatty acids decrease fat storage in livers of obese mice by SREBP-1 suppression.
    Sekiya M; Yahagi N; Matsuzaka T; Najima Y; Nakakuki M; To...
    Hepatology/38(6)/p.1529-1539, 2003-01
  • p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus.
    Yokoo T; Toyoshima H; Miura M; Wang Y; Tada Iida K; Suzuk...
    J Biol Chem/278/p.52919-23, 2003-01
  • Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene.
    Ohashi K; Osuga J; Tozawa R; Kitamine T; Yagyu H; Sekiya ...
    J Biol Chem/278/p.42936-41, 2003-01
  • Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes.
    Misawa K; Horiba T; Arimura N; Hirano Y; Inoue J; Emoto ...
    J Biol Chem/278/p.36176-82, 2003-01
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