SHIMANO Hitoshi
- Articles
- Insulin-independent induction of SREBP-1c expression in the livers of streptozotocin-treated mice.
Matsuzaka T; Shimano H.; Yahagi N; Amemiya-Kudo M; Okazak...
Diabetes/53/p.560-9, 2004-01 - P57(Kip2) regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus
Yokoo T; Toyoshima H; Miura M; Wang YH; Iida KT; Suzuki ...
JOURNAL OF BIOLOGICAL CHEMISTRY/278(52)/pp.52919-52923, 2003-12 - Physiological changes in circulating mannose levels in normal, glucose-intolerant, and diabetic subjects
Sone H; Shimano H; Ebinuma H; Takahashi A; Yano Y; Iida ...
Metabolism/52(8)/pp.1019-1027, 2003-01 - FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products.
Tamura Y; Adachi H; Osuga J; Ohashi K; Yahagi N; Sekiya ...
J Biol Chem/278/p.12613-7, 2003-01 - Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats.
Iida KT; Kawakami Y; Suzuki M; Shimano H.; Toyoshima H; S...
Am J Physiol Endocrinol Metab/284/p.E1125-30, 2003-01 - Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.
Yoshikawa T; Ide T; Shimano H.; Yahagi N; Amemiya-Kudo M...
Mol Endocrinol/17/p.1240-54, 2003-01 - Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.
Ide T; Shimano H.; Yoshikawa T; Yahagi N; Amemiya-Kudo M...
Mol Endocrinol/17/p.1255-67, 2003-01 - p53 Activation in adipocytes of obese mice.
Yahagi N; Shimano H.; Matsuzaka T; Najima Y; Sekiya M; Na...
J Biol Chem/278/p.25395-400, 2003-01 - Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.
Ono H; Shimano H.; Katagiri H; Yahagi N; Sakoda H; Onishi...
Diabetes/52/p.2905-13, 2003-01 - Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter.
Kajihara M; Sone H; Amemiya M; Katoh Y; Isogai M; Shimano...
Biochem Biophys Res Commun/312/p.831-42, 2003-01 - Polyunsaturated fatty acids decrease fat storage in livers of obese mice by SREBP-1 suppression.
Sekiya M; Yahagi N; Matsuzaka T; Najima Y; Nakakuki M; To...
Hepatology/38(6)/p.1529-1539, 2003-01 - p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus.
Yokoo T; Toyoshima H; Miura M; Wang Y; Tada Iida K; Suzuk...
J Biol Chem/278/p.52919-23, 2003-01 - Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene.
Ohashi K; Osuga J; Tozawa R; Kitamine T; Yagyu H; Sekiya ...
J Biol Chem/278/p.42936-41, 2003-01 - Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes.
Misawa K; Horiba T; Arimura N; Hirano Y; Inoue J; Emoto ...
J Biol Chem/278/p.36176-82, 2003-01 - PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity.
Matsumoto M; Ogawa W; Akimoto K; Inoue H; Miyake K; Furuk...
J Clin Invest/112/p.935-44, 2003-01 - Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements.
Yoshikawa T; Shimano H; Yahagi N; Ide T; Amemiya-Kudo M; ...
Journal Biological Chemistory./277/p.1705-1711., 2002-01 - Sterol Regulatory Element-binding Protein (SREBP) Family as Global Regulators of Lipid Synthetic Genes in Energy Metabolism.
Shimano H
Vitamins and Hormones/65/pp.167-194, 2002-01 - Acetyl-coenzyme A Synthetase is a New Lipogenic Enzyme Controlled by Sterol Regulatory Element-binding Protein-1.
Sone H; Shimano H.; Sakakura Y; Inoue N; Amemiya-Kudo M; ...
Am J Physiol Endocrinol Metab/282/p.E222-230, 2002-01 - Dual regulation of mouse delta-5 and-6 desaturase gene expression by SREBP-1 and PPARalpha.
Matsuzaka T; Shimano H.; Yahagi N; Amemiya-Kudo M; Yoshik...
J Lipid Res/43/p.107-114, 2002-01 - Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via phosphatidylinositol-3-kinase-dependent pathway.
Iida KT; Suzuki H; Sone H; Shimano H.; Toyoshima H; Yatoh...
Arterioscler Thromb Vasc Biol/22/p.380-6, 2002-01 - Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers, but not obesity or insulin resistance in Lepob/Lepob mice.
Yahagi N; Shimano H.; Hasty AH; Matsuzaka T; Ide T; Yoshi...
J Biol Chem/277/p.19353-7, 2002-01 - Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.
Amemiya-Kudo M; Shimano H.; Hasty AH; Yahagi N; Yoshikawa...
J Lipid Res. 2/43/p.1220-35, 2002-01 - PPAR gamma ligands, troglitazone and pioglitazone, up-regulate expression of HMG-CoA synthase and HMG-CoA reductase gene in THP-1 macrophages.
Iida KT; Kawakami Y; Suzuki H; Sone H; Shimano H.; Toyosh...
FEBS Lett/520/p.177-81, 2002-01 - Elimination of cholesterol ester from macrophage foam cells by adenovirus-mediated gene transfer of hormone-sensitive lipase.
Okazaki H; Osuga JI; Tsukamoto K; Isoo N; Kitamine T; Tam...
J Biol Chem/277/p.31893-9, 2002-01 - HMG-CoA reductase inhibitor decreases small dense low-density lipoprotein and remnant-like particle cholesterol in patients with type-2 diabetes. .
Sone H; Takahashi A; Shimano H.; Ishibashi S; Yoshino G; ...
Life Sci/71/p.2403, 2002-01 - more...
- Insulin-independent induction of SREBP-1c expression in the livers of streptozotocin-treated mice.