SHIMANO Hitoshi
- Articles
- PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity.
Matsumoto M; Ogawa W; Akimoto K; Inoue H; Miyake K; Furuk...
J Clin Invest/112/p.935-44, 2003-01 - Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements.
Yoshikawa T; Shimano H; Yahagi N; Ide T; Amemiya-Kudo M; ...
Journal Biological Chemistory./277/p.1705-1711., 2002-01 - Sterol Regulatory Element-binding Protein (SREBP) Family as Global Regulators of Lipid Synthetic Genes in Energy Metabolism.
Shimano H
Vitamins and Hormones/65/pp.167-194, 2002-01 - Acetyl-coenzyme A Synthetase is a New Lipogenic Enzyme Controlled by Sterol Regulatory Element-binding Protein-1.
Sone H; Shimano H.; Sakakura Y; Inoue N; Amemiya-Kudo M; ...
Am J Physiol Endocrinol Metab/282/p.E222-230, 2002-01 - Dual regulation of mouse delta-5 and-6 desaturase gene expression by SREBP-1 and PPARalpha.
Matsuzaka T; Shimano H.; Yahagi N; Amemiya-Kudo M; Yoshik...
J Lipid Res/43/p.107-114, 2002-01 - Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via phosphatidylinositol-3-kinase-dependent pathway.
Iida KT; Suzuki H; Sone H; Shimano H.; Toyoshima H; Yatoh...
Arterioscler Thromb Vasc Biol/22/p.380-6, 2002-01 - Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers, but not obesity or insulin resistance in Lepob/Lepob mice.
Yahagi N; Shimano H.; Hasty AH; Matsuzaka T; Ide T; Yoshi...
J Biol Chem/277/p.19353-7, 2002-01 - Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.
Amemiya-Kudo M; Shimano H.; Hasty AH; Yahagi N; Yoshikawa...
J Lipid Res. 2/43/p.1220-35, 2002-01 - PPAR gamma ligands, troglitazone and pioglitazone, up-regulate expression of HMG-CoA synthase and HMG-CoA reductase gene in THP-1 macrophages.
Iida KT; Kawakami Y; Suzuki H; Sone H; Shimano H.; Toyosh...
FEBS Lett/520/p.177-81, 2002-01 - Elimination of cholesterol ester from macrophage foam cells by adenovirus-mediated gene transfer of hormone-sensitive lipase.
Okazaki H; Osuga JI; Tsukamoto K; Isoo N; Kitamine T; Tam...
J Biol Chem/277/p.31893-9, 2002-01 - HMG-CoA reductase inhibitor decreases small dense low-density lipoprotein and remnant-like particle cholesterol in patients with type-2 diabetes. .
Sone H; Takahashi A; Shimano H.; Ishibashi S; Yoshino G; ...
Life Sci/71/p.2403, 2002-01 - Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.
Matsuzaka T; Shimano H.; Yahagi N; Yoshikawa T; Amemiya-K...
J Lipid Res/43/p.911-20., 2002-01 - Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules.
Song H; Shojima N; Sakoda H; Ogihara T; Fujishiro M; Kata...
Biochem Biophys Res Commun/299/p.291-8, 2002-01 - Cerebral hemorrhagic infarction after radiation for pituitary adenoma.
Ogaki S; Suzuki S; Suzuki H; Suzuki M; Shimano H.; Toyosh...
Intern Med/41/p.834-8, 2002-01 - Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases.
Okazaki H; Osuga J; Tamura Y; Yahagi N; Tomita S; Shionoi...
Diabetes/51/p.3368-75, 2002-01 - Insulin up-regulates tumor necrosis factor-alpha production in macrophages through an extracellular-regulated kinase-dependent pathway.
Iida KT; Shimano H; Kawakami Y; Sone H; Toyoshima H; Suzu...
J Biol Chem./276(35)/pp.32531-32537, 2001-08 - Sterol regulatory element-binding proteins (SREBPs): Transcriptional regulators of lipid synthetic genes.
Shimano H
Progress in Lipid Research/40(6)/pp.439-452, 2001-01 - Neutralization of vascular endothelial growth factor prevents collagen-induced arthritis and ameliorates established disease in mice.(共著)
Sone H; Kawakami Y; Sakauchi M; Nakamura Y; Takahashi A; ...
Biochem Biophys Res Commun/281(2)/p.562-568, 2001-01 - Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice : pleiotropic effects on CD36 expression and HDL.(共著)
Chen Z; Ishibashi S; Perrey S; Osuga Ji; Gotoda T; Kitami...
Arterioscler Thromb Vasc Biol/21(3)/p.372-377, 2001-01 - Asialoglycoprotein receptor deficiency in mice lacking the major receptor subunit. Its obligate requirement for the stable expression of oligomeric receptor.(共著)
Tozawa R; Ishibashi S; Osuga J; Yamamoto K; Yagyu H; Ohas...
J Biol Chem/276(16)/p.12624-12628, 2001-01 - Identification of LXR/RXR as an Activator of the Sterol Regulatory Element-Binding Protein(SREBP)-1c Gene Promoter.(共著)
Yoshikawa T; Shimano H.; Amemiya-Kudo M; Yahagi N; Hasty ...
Mol Cell Biol/21/p.2991-3000, 2001-01 - Severe Hypercholesterolemia, Hypertriglyceridemia and Atherosclerosis in mice Lacking Both Leptin and the Low Density Lipoprotein Receptor.
Hasty AH; Shimano H.; Osuga J; Namatame I; Takahashi A; Y...
J Biol Chem/276/p.37402-37408, 2001-01 - Effects of probucol on atherosclerosis of apoE-deficient or LDL receptor-deficient mice.
Yoshikawa T; Shimano H.; Chen Z; Ishibashi S; Yamada N
Horm Metab Res/33/p.472-9, 2001-01 - Elevated levels of vascular endothelial growth factor in the sera of patients with rheumatoid arthritis correlation with disease activity.
Sone H; Sakauchi M; Takahashi A; Suzuki H; Inoue N; Iida ...
Life sciences/69(16)/pp.1861-1869, 2001-01 - Sterol Regulatory Element-Binding Proteins Induce an Entire Pathway of Cholesterol Synthesis.
Sakakura Y; Shimano H.; Sone H; Takahashi A; Inoue K; Toy...
Biochem Biophys Res Commun/286/p.176-83, 2001-01 - more...
- PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity.