SHIMANO Hitoshi
- Articles
- Sterol regulatory element-binding protein-1 as a dominant transcription factor for gene regulation of lipogenic enzymes in the liver Trends in Cardiovascular Medicine
Shimano H
Trends in Cardiovascular Medicine/10/p.275-8, 2000-01 - Sterol regulatory element-binding protein-1 as a dominant transcription factor for gene regulation of lipogenic enzymes in the liver.
Shimano H
Trends in Cardiovascular Medicine/10/p.275-278, 2000-01 - Transcriptional regulation of the ATP citrate-lyase gene by sterol regulatory element-binding proteins.(共著)
Sato R; Okamoto A; Inoue J; Miyamoto W; Sakai Y; Emoto N...
J Biol Chem/275/p.12497-12502, 2000-01 - Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia.(共著)
Yagyu H; Kitamine T; Osuga J; Tozawa R; Chen Z; Kaji Y; O...
J Biol Chem/275/p.21324-21330, 2000-01 - Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level.(共著)
Hasty AH; Shimano H.; Yahagi N; Amemiya-Kudo M; Perrey S...
J Biol Chem/275/p.31069-31077, 2000-01 - Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene.(共著)
Amemiya-Kudo M; Shimano H.; Yoshikawa T; Yahagi N; Hasty ...
J Biol Chem/275/pp.31078-31085, 2000-01 - Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes.(共著)
Shimano H.; Yahagi N; Amemiya-Kudo M; Hasty AH; Osuga J; ...
J Biol Chem/274/p.35832-35839, 1999-01 - Absence of Cd36 mutation in the original spontaneously hypertensive rats with insulin resistance [letter].(共著)
Gotoda T; Lizuka Y; Kato N; Osuga J; Bihoreau MT; Murakam...
Nat Genet/22/p.226-228, 1999-01 - Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL.(共著)
Horton JD; Shimano H.; Hamilton RL; Brown MS; Goldstein JL
J Clin Invest/103/p.1067-1076, 1999-01 - A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids.
Yahagi N; Shimano H.; Hasty AH; Amemiya-Kudo M; Okazaki H; Tam...
J Biol Chem/274/pp.35840-35844, 1999-01 - Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver.(共著)
Shimomura I; Shimano H.; Korn BS; Bashmakov Y; Horton JD
J Biol Chem/273/p.35299-35306, 1998-01 - Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice.(共著)
Horton JD; Bashmakov Y; Shimomura I; Shimano H
Proc Natl Acad Sci USA/95/p.5987-5992, 1998-01 - Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.(共著)
Horton JD; Shimomura I; Brown MS; Hammer RE; Goldstein J...
J Clin Invest/101/p.2331-2339, 1998-01 - Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E.(共著)
Osuga J; Yonemoto M; Yamada N; Shimano H.; Yagyu H; Ohash...
J Clin Invest/102/p.386-394, 1998-01 - Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.(共著)
Shimomura I; Shimano H.; Horton JD; Goldstein JL; Brown MS
J Clin Invest/99/p.838-845, 1997-01 - Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver.(共著)
Shimomura I; Bashmakov Y; Shimano H.; Horton JD; Goldstei...
Proc Natl Acad Sci USA/94/p.12354-12359, 1997-01 - Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.(共著)
Shimano H.; Horton JD; Shimomura I; Hammer RE; Brown MS; ...
J Clin Invest/99/p.846-854, 1997-01 - Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene [see comments].(共著)
Shimano H.; Shimomura I; Hammer RE; Herz J; Goldstein JL...
J Clin Invest/100/p.2115-2124, 1997-01 - Suppression of neutral cholesterol ester hydrolase activity by antisense DNA of hormone-sensitive lipase.(共著)
Osuga J; Ishibashi S; Shimano H.; Inaba T; Kawamura M; Ya...
Biochem Biophys Res Commun/233/p.655-657, 1997-01 - Effect of macrophage colony stimulating factor on the advanced atherosclerosis in Watanabe heritable hyperlipidemic rabbits.(共著)
Watanabe Y; Inaba T; Shimano H.; Gotoda T; Kawamura M; Sh...
Horm Metab Res/29/p.507-509, 1997-01 - Transgenic mouse and gene therapy.(共著)
島野 仁
Diabetes/45Suppl(3)/p.S129-132, 1996-01 - Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
Shimano H.; Horton JD; Hammer RE; Shimomura I; Brown MS; ...
J Clin Invest/98/p.1575-1584, 1996-01 - Dose-dependent effect of niceritrol on plasma lipoprotein-a.
Teramoto T; Yamada N; Shimano H.; Oka Y; Itakura H; Saito...
Scand J Clin Lab Invest/56/p.359-365, 1996-01 - Transgenic mouse and gene therapy.
Harada K; Shimano H.; Ishibashi S; Yamada N
Diabetes/45(Suppl 3)/p.S129-32, 1996-01 - Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall.
Shimano H.; Ohsuga J; Shimada M; Namba Y; Gotoda T; Harad...
J Clin Invest./95(2)/p.469-476, 1995-01 - more...
- Sterol regulatory element-binding protein-1 as a dominant transcription factor for gene regulation of lipogenic enzymes in the liver Trends in Cardiovascular Medicine