SHIMANO Hitoshi

Researcher's full information

Articles
  • Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice.(共著)
    Horton JD; Bashmakov Y; Shimomura I; Shimano H
    Proc Natl Acad Sci USA/95/p.5987-5992, 1998-01
  • Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.(共著)
    Horton JD; Shimomura I; Brown MS; Hammer RE; Goldstein J...
    J Clin Invest/101/p.2331-2339, 1998-01
  • Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E.(共著)
    Osuga J; Yonemoto M; Yamada N; Shimano H.; Yagyu H; Ohash...
    J Clin Invest/102/p.386-394, 1998-01
  • Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.(共著)
    Shimomura I; Shimano H.; Horton JD; Goldstein JL; Brown MS
    J Clin Invest/99/p.838-845, 1997-01
  • Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver.(共著)
    Shimomura I; Bashmakov Y; Shimano H.; Horton JD; Goldstei...
    Proc Natl Acad Sci USA/94/p.12354-12359, 1997-01
  • Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.(共著)
    Shimano H.; Horton JD; Shimomura I; Hammer RE; Brown MS; ...
    J Clin Invest/99/p.846-854, 1997-01
  • Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene [see comments].(共著)
    Shimano H.; Shimomura I; Hammer RE; Herz J; Goldstein JL...
    J Clin Invest/100/p.2115-2124, 1997-01
  • Suppression of neutral cholesterol ester hydrolase activity by antisense DNA of hormone-sensitive lipase.(共著)
    Osuga J; Ishibashi S; Shimano H.; Inaba T; Kawamura M; Ya...
    Biochem Biophys Res Commun/233/p.655-657, 1997-01
  • Effect of macrophage colony stimulating factor on the advanced atherosclerosis in Watanabe heritable hyperlipidemic rabbits.(共著)
    Watanabe Y; Inaba T; Shimano H.; Gotoda T; Kawamura M; Sh...
    Horm Metab Res/29/p.507-509, 1997-01
  • Transgenic mouse and gene therapy.(共著)
    島野 仁
    Diabetes/45Suppl(3)/p.S129-132, 1996-01
  • Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
    Shimano H.; Horton JD; Hammer RE; Shimomura I; Brown MS; ...
    J Clin Invest/98/p.1575-1584, 1996-01
  • Dose-dependent effect of niceritrol on plasma lipoprotein-a.
    Teramoto T; Yamada N; Shimano H.; Oka Y; Itakura H; Saito...
    Scand J Clin Lab Invest/56/p.359-365, 1996-01
  • Transgenic mouse and gene therapy.
    Harada K; Shimano H.; Ishibashi S; Yamada N
    Diabetes/45(Suppl 3)/p.S129-32, 1996-01
  • Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall.
    Shimano H.; Ohsuga J; Shimada M; Namba Y; Gotoda T; Harad...
    J Clin Invest./95(2)/p.469-476, 1995-01
  • Overexpression of apolipoprotein E prevents development of diabetic hyperlipidemia in transgenic mice.
    Yamamoto K; Shimano H.; Shimada M; Kawamura M; Gotoda T; ...
    Diabetes/44/p.580-585, 1995-01
  • Role of apolipoprotein E in lipoprotein metabolism and in the process of atherosclerosis.
    Yamada N; Shimano H.; Yazaki Y
    J Atheroscler Thromb/2/p.S29-33, 1995-01
  • Effects of platelet-derived growth factor on the synthesis of lipoprotein lipase in human monocyte-derived macrophages.
    Inaba T; Kawamura M; Gotoda T; Harada K; Shimada M; Ohsug...
    Arterioscler Thromb Vasc Biol./15(4)/p.522-528, 1995-01
  • Dextran sulfate, a competitive inhibitor for scavenger receptor, prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
    Tsubamoto Y; Yamada N; Watanabe Y; Inaba T; Shiomi M; Shi...
    Atherosclerosis./106(1)/p.43-50, 1994-01
  • Overexpression of human lipoprotein lipase enhances uptake of lipoproteins containing apoliprotein B-100 in transfected cells.(共著)
    Kawamura M; Shimano H.; Gotoda T; Harada K; Shimada M; Oh...
    Arterioscler Thromb/14/p.235-242, 1994-01
  • Establishment of enzyme-linked immunosorbent assays for lipoprotein lipase with newly developed antibodies.
    Kawamura M; Gotoda T; Mori N; Shimano H.; Kozaki K; Harad...
    J Lipid Res./35(9)/p.1688-1697, 1994-01
  • Secretion-recapture process of apolipoprotein E in hepatic uptake of chylimicron remnants in transgenic mice.(共著)
    Shimano H.; Namba Y; Ohsuga J; Kawamura M; Yamamoto K; Sh...
    J Clin Invest/93(5)/p.2215-2223, 1994-01
  • Elevated serum and urinary thrombomodulin levels in patients with non-insulin-dependent diabetes mellitus.
    Shimano H.; Takahashi K; Kawakami M; Gotoda T; Harada K; ...
    Clin Chim Acta./225(2)/p.89-96, 1994-01
  • Metabolism of chylomicron remnants in transgenic mice expressing apolipoprotein E in the intestine.(共著)
    Shimano H.; Namba Y; Ohsuga J; Yamamoto K; Shimada M; Got...
    Biophys Res Commun/200/p.716-721, 1994-01
  • Regulation of low density lipoprotein receptor activity in Chinese hamster ovary cells transfected with the c-fms gene.(共著)
    Yamamoto K; Shimano H.; Inaba T; Gotoda T; Harada K; Shim...
    FEBS Lett/356(1)/p.72-75, 1994-01
  • Overexpression of human lipoprotein lipase in transgenic mice. Resistance to diet-induced hypertriglyceridemia and hypercholesterolemia.(共著)
    Shimada M; Shimano H.; Gotoda T; Yamamoto K; Kawamura M; ...
    J Biol Chem/269/p.11673, 1994-01
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