HIROKAWA Takatsugu
- Articles
- Topology-selective photo-crosslinking of G-quadruplexes via dual G-quartet and groove recognition
Ishikawa Ryo; Yanagita Kazuki; Shimada Sayuri; Sasaki ...
CHEMICAL COMMUNICATIONS/60(92)/pp.13550-13553, 2024-11-14 - Discovery and Structural Analysis of Metabolites of Vitamin D3 Lactones
Iijima Kazuto; Sakamoto Ryota; Tsutsumi Rino; Nakaya ...
CHEMICAL & PHARMACEUTICAL BULLETIN/72(10)/pp.899-908, 2024-10 - Structural insights into molecular-targeting helix-loop-helix peptide against vascular endothelial growth factor-A
Michigami Masataka; Notsu Kunpei; Kamo Masayuki; Hirok...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS/734, 2024-11-19 - Anthricin-induced hyperactive proteasome and its molecular mechanism
Sakamoto Kotaro; Fujimoto Runa; Kamiyama-Ando Erina; H...
BIOCHEMISTRY AND BIOPHYSICS REPORTS/40, 2024-12 - Pseudoirreversible inhibition elicits persistent efficacy of a sphingosine 1-phosphate receptor 1 antagonist
Maruyama Yuya; Ohsawa Yusuke; Suzuki Takayuki; Yamauch...
NATURE COMMUNICATIONS/15(1), 2024-07-19 - Hexestrol, an estrogen receptor agonist, inhibits Lassa virus entry
Zhang Zihan; Takenaga Toru; Fehling Sarah Katharina; I...
JOURNAL OF VIROLOGY/98(7), 2024-07-23 - Cyclic Peptides KS-133 and KS-487 Multifunctionalized Nanoparticles Enable Efficient Brain Targeting for Treating Schizophrenia
Sakamoto Kotaro; Iwata Seigo; Jin Zihao; Chen Lu; Miy...
JACS AU/Epub, 2024-06-20 - Prediction of the binding mechanism of a selective DNA methyltransferase 3A inhibitor by molecular simulation
Kudo Genki; Hirao Takumi; Harada Ryuhei; Hirokawa Tak...
Scientific reports/14(1), 2024-06-12 - Interaction modes of human orexin 2 receptor with selective and nonselective antagonists studied by NMR spectroscopy
Imamura Kayo; Akagi Ken-Ichi; Miyanoiri Yohei; Tsujimo...
STRUCTURE/32(3), 2024-03-07 - Crystal structure of Staphylococcus aureus lipase complex with unsaturated petroselinic acid
Kitadokoro Julia; Kamitani Shigeki; Okuno Yukiko; Hiki...
FEBS OPEN BIO/14(6)/pp.942-954, 2024-06 - Lipid bilayer membrane permeability mechanism of the K-Ras (G12D)-inhibitory bicyclic peptide KS-58 elucidated by molecular dynamics simulations
Sakamoto Kotaro; Hirokawa Takatsugu
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS/100, 2024-03-01 - Biological Evaluation of Isosteric Applicability of 1,3-Substituted Cuneanes as m-Substituted Benzenes Enabled by Selective Isomerization of 1,4-Substituted Cubanes
Fujiwara Kan; Nagasawa Shota; Maeyama Ryusei; Segawa ...
CHEMISTRY-A EUROPEAN JOURNAL/30(11), 2024-02-21 - Site Identification and Next Choice Protocol for Hit-to-Lead Optimization
Kudo Genki; Hirao Takumi; Yoshino Ryunosuke; Shigeta ...
JOURNAL OF CHEMICAL INFORMATION AND MODELING/64(11)/pp.4475-4484, 2024-05-20 - AAp-MSMD: Amino Acid Preference Mapping on Protein-Protein Interaction Surfaces Using Mixed-Solvent Molecular Dynamics
Kudo Genki; Yanagisawa Keisuke; Yoshino Ryunosuke; Hir...
JOURNAL OF CHEMICAL INFORMATION AND MODELING/63(24)/pp.7768-7777, 2023-12-25 - Modeling the structure of the transmembrane domain of T1R3, a subunit of the sweet taste receptor, with neohesperidin dihydrochalcone using molecular dynamics simulation
Nakagita Tomoya; Matsuya Takumi; Narukawa Masataka; Ko...
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY/87(12)/pp.1470-1477, 2023-11-21 - Identification of Chemicals That Abrogate Folate-Dependent Inhibition of Starch Accumulation in Non-Photosynthetic Plastids of Arabidopsis
Kawada Yoshihiro; Hayashi Eriko; Katsuragi Yuya; Imamu...
PLANT AND CELL PHYSIOLOGY/Epub, 2023-10-06 - Identification of a novel CDK9 inhibitor targeting the intramolecular hidden cavity of CDK9 induced by Tat binding
Asamitsu Kaori; Hirokawa Takatsugu; Okamoto Takashi
PLOS ONE/17(11), 2022-04-01 - A multipoint guidance mechanism for β-barrel folding on the SAM complex
Takeda Hironori; Busto Jon V; Lindau Caroline; Tsutsum...
NATURE STRUCTURAL & MOLECULAR BIOLOGY/30(2)/pp.176-187, 2023-02-01 - Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication
Tsukamoto Yuta; Hiono Takahiro; Yamada Shintaro; Matsu...
SCIENCE/379(6632)/pp.586-591, 2023-02-10 - Quantitative comparison of protein-protein interaction interface using physicochemical feature-based descriptors of surface patches
Shin Woong-Hee; Kumazawa Keiko; Imai Kenichiro; Hiroka...
Frontiers in molecular biosciences/10, 2023-04-01 - Pocket to concavity: a tool for the refinement of protein-ligand binding site shape from alpha spheres
Kudo Genki; Hirao Takumi; Yoshino Ryunosuke; Shigeta ...
BIOINFORMATICS/39(4), 2023-04-03 - Structural and energetic basis for differential binding of Ebola and Marburg virus glycoproteins to a bat-derived Niemann-Pick C1 protein
Igarashi Manabu; Hirokawa Takatsugu; Takada Ayato
JOURNAL OF INFECTIOUS DISEASES/228(7:SI)/pp.S479-S487, 2023-04-29 - Distinct Profiles of Desensitization of µ-Opioid Receptors Caused by Remifentanil or Fentanyl: In Vitro Assay with Cells and Three-Dimensional Structural Analyses
Uezono Eiko; Mizobuchi Yusuke; Miyano Kanako; Ohbuchi ...
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES/24(9), 2023-05-06 - Regulation of thrombin activity by ligand-induced topological alteration in a thrombin-binding aptamer
Sasaki Shogo; Ma Yue; Hirokawa Takatsugu; Ikebukuro K...
CHEMICAL COMMUNICATIONS/59(57)/pp.8862-8865, 2023-07-13 - Differential Metabolic Stability of 4α,25- and 4β,25-Dihydroxyvitamin D3 and Identification of Their Metabolites
Mizumoto Yuka; Sakamoto Ryota; Iijima Kazuto; Nakaya ...
BIOMOLECULES/13(7), 2023-06-24 - more...
- Topology-selective photo-crosslinking of G-quadruplexes via dual G-quartet and groove recognition