HIROKAWA Takatsugu
- Articles
- AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys(25)-Cys(192)) formation of functional significance for VIPR2
Sakamoto Kotaro; Asano Satoshi; Ago Yukio; Hirokawa T...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS/636(1)/pp.10-16, 2022-12 - Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2'-O-ribose methyltransferases
Bergant Valter; Yamada Shintaro; Grass Vincent; Tsukam...
EMBO JOURNAL/41(17), 2022-09 - Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1
Hirokawa Takatsugu; BB Queliconi; W Kojima; M Kimura; K ...
J Cell Sci./134(22)/p.jcs258653, 2021-11 - [In-Silico Drug Discovery Support-Current Situation and Challenges]
Hirokawa Takatsugu
Gan to kagaku ryoho. Cancer & chemotherapy/49(4)/pp.359-364, 2022-04-01 - Inverse Mixed-Solvent Molecular Dynamics for Visualization of the Residue Interaction Profile of Molecular Probes
Yanagisawa Keisuke; Yoshino Ryunosuke; Kudo Genki; Hiroka...
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES/23(9), 2022-04-26 - Chemosynthetic ethanolamine plasmalogen stimulates gonadotropin secretion from bovine gonadotrophs by acting as a potential GPR61 agonist
Kadokawa Hiroya; Yoshino Ryunosuke; Saito Risa; Hiroka...
ANIMAL REPRODUCTION SCIENCE/241, 2022-05-13 - Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti
Inaba Kazue; Ebihara Kana; Senda Miki; Yoshino Ryunosuke...
BMC Biology/20(1)/p.43, 2022-02 - MDContactCom: a tool to identify differences of protein molecular dynamics from two MD simulation trajectories in terms of interresidue contacts
Motono Chie; Yanagida Shunsuke; Sato Miwa; Hirokawa Taka...
BIOINFORMATICS/38(1)/pp.273-274, 2022-01 - Evaluating cepharanthine analogues as natural drugs against SARS-CoV-2
Hijikata Atsushi; Shionyu-Mitsuyama Clara; Nakae Setsu...
FEBS OPEN BIO/12(1)/pp.285-294, 2022-01 - Heme-dependent recognition of 5-aminolevulinate synthase by the human mitochondrial molecular chaperone ClpX
Nomura Kazumi; Kitagawa Yu; Aihara Marina; Ohki Yusuke; F...
FEBS LETTERS/595(24)/pp.3019-3029, 2021-12 - 2-Carba-lysophosphatidic acid is a novel beta-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition
Fukasawa Keiko; Gotoh Mari; Uwamizu Akiharu; Hirokawa ...
SCIENTIFIC REPORTS/11(1), 2021-08 - Vinylnaphthalene-bearing hexaoxazole as a fluorescence turn-on type G-quadruplex ligand
Ma Yue; Wakabayashi Yuki; Watatani Naruyuki; Saito Ry...
ORGANIC & BIOMOLECULAR CHEMISTRY/19(37)/pp.8035-8040, 2021-10 - The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis
Sekiya Motohiro; Kainoh Kenta; Sugasawa Takehito; Yosh...
Nature communications/12(1)/p.6315, 2021-11 - JBIR-155, a Specific Class D beta-Lactamase Inhibitor of Microbial Origin
Nishimura Takehiro; Kawahara Teppei; Kagaya Noritaka; ...
ORGANIC LETTERS/23(11)/pp.4415-4419, 2021-06 - Structural Insights into the Interaction of Filovirus Glycoproteins with the Endosomal Receptor Niemann-Pick C1: A Computational Study
Igarashi Manabu; Hirokawa Takatsugu; Takadate Yoshihir...
VIRUSES-BASEL/13(5), 2021-05 - Protein druggability assessment for natural products using in silico simulation: A case study with estrogen receptor and the flavonoid genistein
Ohbuchi Katsuya; Hirokawa Takatsugu
Gene/791, 2021-05 - Structural insights from an in silico molecular docking simulation of complement component 3a receptor 1 with an antagonist
Misawa Kensuke; Sugai Yoshiya; Fujimori Taketoshi; Hiroka...
Journal of molecular graphics & modelling/106, 2021-04 - Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment
Ohashi Hirofumi; Watashi Koichi; Saso Wakana; Shionoya...
iScience/24(4), 2021-03 - Current Challenges and Opportunities in Designing Protein-Protein Interaction Targeted Drugs
Shin Woong-Hee; Kumazawa Keiko; Imai Kenichiro; Hiroka...
Advances and applications in bioinformatics and chemistry : AABC/13/pp.11-25, 2020-04-01 - Non-steroidal inhibitors of Drosophila melanogaster steroidogenic glutathione S-transferase Noppera-bo
Koiwai Kotaro; Morohashi Kana; Inaba Kazue; Ebihara Kana...
Journal of Pesticide Science/46(1-2)/pp.75-87, 2021-01 - Linear consecutive hexaoxazoles as G4 ligands inducing chair-type anti-parallel topology of a telomeric G-quadruplex
Sasaki Shogo; Ma Yue; Ishizuka Takumi; Bao Hong-Liang...
RSC ADVANCES/10(71)/pp.43319-43323, 2020-12 - Generation of KS-58 as the first K-Ras(G12D)-inhibitory peptide presenting anti-cancer activity in vivo
Sakamoto Kotaro; Masutani Teruaki; Hirokawa Takatsugu
SCIENTIFIC REPORTS/10(1), 2020-12 - SYNTHESIS AND BIOLOGICAL EVALUATION OF NMDI14 DERIVATIVES AS ANTI-MESOTHELIOMA AGENTS
Hong Nhung Nguyen; Suzuki Koya; Kimura Yasuaki; Hiroka...
HETEROCYCLES/100(2)/pp.253-266, 2020-02 - Ibuprofen, a nonsteroidal anti-inflammatory drug, is a potent inhibitor of the human sweet taste receptor
Nakagita Tomoya; Taketani Chiaki; Narukawa Masataka; H...
Chemical senses/45(8)/pp.667-673, 2020-10 - Positive/Negative Allosteric Modulation Switching in an Umami Taste Receptor (T1R1/T1R3) by a Natural Flavor Compound, Methional
Toda Yasuka; Nakagita Tomoya; Hirokawa Takatsugu; Yama...
Scientific reports/8(1), 2018-04 - more...
- AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys(25)-Cys(192)) formation of functional significance for VIPR2