SHICHINO Yuichi

Affiliation
Institute of Medicine
Official title
Professor
Research fields
Molecular biology
Research keywords
RNA
translation
ribosome profiling
Research projects
リソソームを「反応場」とする翻訳・複合体形成・局在化の協奏2025-04 -- 2028-03七野 悠一日本学術振興会/Grant-in-Aid for Transformative Research Areas (B)33,930,000Yen
翻訳と反応場から考える蛋白質の新しい社会像の領域推進2025-04 -- 2028-03小林 穂高日本学術振興会/Grant-in-Aid for Transformative Research Areas(B)5,980,000Yen
非膜性オルガネラによるRNA時空間制御を介したDNA損傷応答2023-10 -- 2027-03七野悠一日本医療研究開発機構/革新的先端研究開発支援事業 ソロタイプ「ストレスへの応答と疾病発症に至るメカニズムの解明」研究開発領域52,000,000Yen
細胞内顆粒P-bodyによるmRNAの空間的制御を介した細胞周期調節機構2023-04 -- 2026-03七野 悠一日本学術振興会/Grant-in-Aid for Scientific Research4,680,000Yen
非典型局所翻訳を包括的に解明するAPEX-Ribo-Seq法の確立2023-04 -- 2025-03七野 悠一Ministry of Education, Culture, Sports, Science and Technology, Japan/Grant-in-Aid for Transformative Research Areas(A)10,400,000Yen
APEX-Ribo-Seq: 近傍標識による非典型局所翻訳の網羅解析2021-09 -- 2023-03七野 悠一Ministry of Education, Culture, Sports, Science and Technology, Japan/Grant-in-Aid for Transformative Research Areas(A)10,400,000Yen
Cooperative expression regulation by eukaryotic translation initiation factor eIF4A1 and glutamine metabolism2021-04 -- 2023-03Shichino YuichiJapan Society for the Promotion of Science/若手研究4,550,000Yen
基本翻訳因子パラログに潜む選択性を利用した環境適応機構2019-04 -- 2020-03七野 悠一日本学術振興会/Grant-in-Aid for JSPS Fellows4,810,000Yen
分裂酵母の減数分裂に必須なノンコーディングRNAであるmeiRNAの局在化機構2011 -- 2013七野 悠一日本学術振興会/Grant-in-Aid for JSPS Fellows1,900,000Yen
Career history
2025-09 -- (current)University of TsukubaInstitute of MedicineProfessor
2025-04 -- 2025-08RIKENPioneering Research InsistuteSenior scientist
2022-04 -- 2025-03RIKENCluster for Pioneering ResearchResearch Scientist
2022-04 -- 2025-08Tokyo University of ScienceInstitute of Arts and SciencesPart-time Lecturer
2020-04 -- 2022-03RIKENRNA Systems Biochemistry Laboratory, Cluster for Pioneering ResearchSpecial Postdoctoral Researcher
2019-04 -- 2020-03JSPSPostdoctoral Researcher
2019-04 -- 2020-03RIKENRNA Systems Biochemistry Laboratory, Cluster for Pioneering ResearchVisiting researcher
2017-04 -- 2019-03RIKENRNA Systems Biochemistry LaboratoryPostdoctoral Researcher
2014-07 -- 2017-03National Institute for Basic BiologyLaboratory of Cell ResponsesResearcher
2011-04 -- 2014-03JSPS特別研究員（DC1）
Academic background
2011-04 -- 2014-06The University of Tokyo Graduate School of Science Department of Biophysics and Biochemistry
2009-04 -- 2011-03The University of Tokyo Graduate School of Science Department of Biophysics and Biochemistry
2005-04 -- 2009-03The University of Tokyo School of Science Department of Biophysics and Biochemistry
Degree
2014-06博士（理学）東京大学
Academic societies
-- (current)THE RNA SOCIETY OF JAPAN
-- (current)THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
2022-06 -- (current)The Japanese Biochemical Society
Honors & Awards
2023-03RIKEN BAIHO Award (RIKEN Excellent Achievement Award)Novel mechanism for the suppression of the integrated stress response by a viral protein
2023-01Presentation Award Biology PrizeSelective translation driven by spatial sequestration
2019-09EMBL Advanced Training Centre Corporate Partnership Programme Fellowship
2018-08Nature Structural & Molecular Biology Poster Prize [International symposium "Proteins: From the Cradle to the Grave"]
2018-06Travel Award RNA 2018
2016-12Poster Award
Articles
Books
  • 75 RNP顆粒研究を加速するトランスクリプトーム解析技術
    白木 賢太郎; 七野 悠一
    相分離生物学の全貌/東京化学同人, 2020-11
Conference, etc.
  • Analysis of the nuclear dot formation by meiRNA, a non-coding RNA species essential for meiosis.
    Shichino Yuichi; Yamashita Akira; Yamamoto Masayuki
    The Sixth International Fission Yeast Meeting/2011-06
  • Functional analysis of meiRNA, a non-coding RNA species essential for meiosis in fission yeast.
    Shichino Yuichi; Yamashita Akira; Yamamoto Masayuki
    EMBO Conference on Fission Yeast: pombe 2013/2013-06
  • Spatial control in the Mmi1/DSR system that selectively eliminates meiotic transcripts.
    Shichino Yuichi; Yamashita Akira; Yamamoto Masayuki
    Pombe2015 (8th International Fission Yeast Meeting)/2015-06
  • 分裂酵母のYTHドメインタンパク質Mmi1は減数分裂特異的なmRNAの核内凝集を促進し翻訳を抑制する
    七野 悠一; 山本 正幸; 山下 朗
    日本分子生物学会年会プログラム・要旨集(Web)/2016
  • The YTH domain-containing protein Mmi1 induces intranuclear foci formation of meiotic transcripts through its self-interaction and sequesters them from the translation machinery.
    Shichino Yuichi; Yamamoto Masayuki; Yamashita Akira
    RNA 2016 (21st Annual Meeting of the RNA society)/2016-06
  • Selective translation mechanism through two paralogs of eukaryotic initiation factor 4A
    Shichino Yuichi; Mito Mari; Iwasaki Shintaro
    International symposium "Proteins; From the cradle to the grave"/2018-08-26
  • Eukaryotic initiation factor 4A paralogs promote selective translation to modulate the response to mTOR inhibition
    七野 悠一
    EMBO Workshop: Protein Synthesis and Translation Control/2019-09-06
  • 翻訳開始因子eIF4Aのパラログは選択的にmRNAに結合しmTOR阻害に伴う翻訳抑制を調節する
    七野 悠一; 水戸 麻理; 岩崎 信太郎
    第43回 日本分子生物学会年会 1F-06「拡大するTOR世界の新展開」/2020-12-02--2020-12-04
  • A specific eIF4A paralog facilitates LARP1-mediated translation repression during mTORC1 inhibition
    Shichino Yuichi; Mito Mari; Ingolia Nicholas T.; Iwasa...
    RNA 2021/2021-05-24--2021-06-04
  • A specific eIF4A paralog facilitates LARP1-mediated translation repression during mTORC1 inhibition
    Shichino Yuichi; Mito Mari; Ingolia Nicholas T.; Iwasa...
    EMBL Conference: Protein Synthesis and Translational Control/2021-09-07--2021-09-10
  • 翻訳開始因子eIF4A1はLARP1による翻訳抑制を促進する
    七野 悠一; 水戸 麻理; 柏木 一宏; 髙橋 真梨; 伊藤 拓宏; Ingolia Nicholas...
    日本プロテオーム学会2022年大会/2022-08-09
  • Novel repressive role of eIF4A1 during mTORC1 inhibition
    Shichino Yuichi
    第60回生物物理学会年会/2022-09-29
  • P-bodyのトランスクリプトーム解析により明らかとなった翻訳の時空間的制御の重要性
    七野 悠一
    基礎生物学研究所部門公開セミナー/2022-11-08
  • Transcriptomics in P-bodies reveals the importance of spatiotemporal regulation of translation
    Shichino Yuichi; Mito Mari; Iwasaki Shintaro
    第95回 日本生化学会大会/2022-11-09
  • P-bodyのトランスクリプトーム解析により明らかになる時空間的制御の翻訳における重要性
    七野 悠一; 水戸 麻理; 岩崎 信太郎
    第45回日本分子生物学会年会/2022-11-30--2022-12-02
  • Transcriptomics in P-bodies reveals the selective mRNA release to modulate translation upon DNA damage
    Shichino Yuichi; Mito Mari; Iwasaki Shintaro
    第 24 回 日本 RNA 学会年会/2023-07-05--2023-07-07
  • Novel Mechanism of Translation Regulation Explored by the Transcriptome Analysis of Membrane-less Organelles
    七野 悠一
    第6回 ExCELLSシンポジウム/2024-01-22--2024-01-23
  • Transcriptomics in P-bodies reveals the selective mRNA release to modulate translation
    Shichino Yuichi; Mito Mari; Iwasaki Shintaro
    IUPAB2024/2024-06-24
  • Compilation of Local Translation Atlas
    七野 悠一; 戸室 幸太郎; 岩崎 信太郎
    第76回 日本細胞生物学会年会/2024-07-18
  • Understanding components of granules by fluorescence-activated particle sorting (FAPS)
    Shichino Yuichi
    The 5th Asia RNA Club/2024-08-16
  • 翻訳における時空間制御の包括的理解を目指して
    七野 悠一
    第461回つくば分子生命科学セミナー/2024-09-12
  • APEX-Ribo-Seqによる局所翻訳アトラスの編纂
    七野 悠一
    第3回 タンパク質シンポジウム/2025-01-24
  • APEX-Ribo-Seqによる局所翻訳アトラスの編纂
    七野 悠一
    日本プロテオーム学会2025年大会/2025-08-06--2025-08-08

(Last updated: 2025-10-01)