LAZARUS Michael(ラザルス ミハエル)
- 所属
- 医学医療系
- 職名
- 教授
- ORCID
- 0000-0003-3863-4474
- 性別
- 男性
- 科研費番号
- 80469650
- URL
- eメール
- +A6O6GJHaB>8=6:Aa@6XgcJaIHJ@J76a68a?E
- 研究室
- 国際統合睡眠医科学研究機構
- 電話
- 029-853-3681
- 研究分野
神経化学・神経薬理学 神経解剖学・神経病理学 神経生理学・神経科学一般 - 研究キーワード
シングルセル/シングル核 RNA-seq 睡眠 行動中のマウスの神経活動の制御 光遺伝学 肥満 冬眠 食欲 - 研究課題
Solving the Mystery of Immune Regulation by Sleep 2024-03 -- 2025-08 LAZARUS Michael Chan Zuckerberg Initiative/Collaborative Pairs Pilot Project Awards (Cycle 2) 15,000,000円 Gliosomnia and immunity: decoding brain-immune interactions in sleep 2023-04 -- 2025-03 ラザルス ミハエル 日本学術振興会/学術変革領域研究(A)(公募研究) 13,000,000円 中脳辺縁系グリア・神経相互作用による眠気のメカニズムの解明 2021 -- 2025 LAZARUS Michael 日本学術振興会/基盤研究(B) 17,030,000円 レム睡眠と食欲の意志動力学 2019 -- 2020 LAZARUS Michael 日本学術振興会/新学術領域研究(研究領域提案型) 7,540,000円 パーキンソン病における睡眠障害のメカニズム: 神経回路の観点から 2018-04 -- 2020-03 LAZARUS Michael 日本学術振興会/特別研究員奨励費 2,400,000円 低体温誘導の記憶へのリスクと可塑性 2018 -- 2019 LAZARUS Michael 日本学術振興会/新学術領域研究(研究領域提案型) 5,720,000円 レム睡眠と食欲の意志動力学 2017-04 -- 2019-03 ラザルス ミハエル 日本学術振興会/科学研究費補助金 新学術領域研究 9,100,000円 動機づけ行動による徐波睡眠制御における側坐核の役割 2017-04 -- 2021-03 ラザルス ミハエル 日本学術振興会/科学研究費基盤研究(B)(一般) 17,290,000円 自由行動マウスのアデノシンA2A受容体を利用した光薬理学 2016-11 -- 2019-10 ラザルス ミハエル 公益財団法人内藤記念科学振興財団/研究助成 3,000,000円 光を用いた睡眠の機能と制御機構の統合的解析 2016-10 -- 2021-09 柳沢 正史 科学技術振興機構(JST)/科学技術振興機構 戦略的創造研究推進事業(CREST) 52,000,000円 さらに表示... - 職歴
2022-03 -- (現在) 筑波大学国際統合睡眠医科学研究機構(WPI-IIIS)教授・主任研究者 2013-04 -- 2022-02 筑波大学国際統合睡眠医科学研究機構准教授・主任研究者 2007-09 -- 2013-03 大阪バイオサイエンス研究所裏出良博研究室研究員 2002-07 -- 2007-08 ハーバード大学医学大学院神経学講師 1999-06 -- 2002-07 大阪バイオサイエンス研究所早石修研究室博士研究員 - 学歴
1990-10 -- 1998-07 ユリウス・マクシミリアン大学ヴュルツブルク 化学・薬学部 - 取得学位
1998-07 博士(理学) ユリウス・マクシミリアン大学ヴュルツブルク - 所属学協会
2001-02 -- (現在) 日本フンボルト協会 2009-04 -- (現在) 日本神経科学学会 2009-08 -- (現在) 日本睡眠学会 2003-01 -- (現在) 北米神経科学学会 2001-02 -- (現在) Humboldt Foundation Network - 論文
- Enhancement of Haloperidol-Induced Catalepsy by GPR143, an L-Dopa Receptor, in Striatal Cholinergic Interneurons
Arai Masami; Suzuki Etsuko; Kitamura Satoshi; Otaki M...
JOURNAL OF NEUROSCIENCE/44(11), 2024-03-13 - Mental health: The REM sleep paradox in depression
Hasegawa Emi; Lazarus Michael
CURRENT BIOLOGY/34(15), 2024-08-05 - Anterior cingulate cortex projections to the dorsal medial striatum underlie insomnia associated with chronic pain
Li Ya-Dong; Luo Yan-Jia; Su Wei-Kun; Ge Jing; Crowthe...
NEURON/112(8), 2024-04-17 - Comprehensive mapping of histamine H1 receptor mRNA in the mouse brain
Futagawa Asako; Tsuneoka Yousuke; Lazarus Michael; Ois...
JOURNAL OF COMPARATIVE NEUROLOGY/532(5), 2024-05 - Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors
Roy Koustav; Zhou Xuzhao; Otani Rintaro; Yuan Ping-Ch...
Nature Communications/15(1)/p.3661, 2024-04-30 - Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep
Mizoguchi A; Eguchi N; Kimura K; Kiyohara Y; Qu WM; ...
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA/98(20)/pp.11674-11679, 2001-09 - EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses
Lazarus Michael; Yoshida Kyoko; Coppari Roberto; E. Ba...
NATURE NEUROSCIENCE/10(9)/pp.1131-1133, 2007-09 - Prostaglandin E2 Induces Long-Lasting Inhibition of Noradrenergic Neurons in the Locus Coeruleus and Moderates the Behavioral Response to Stressors
Mukai Yasutaka; Okubo Tatsuo S.; Lazarus Michael; Ono ...
JOURNAL OF NEUROSCIENCE/43(47)/pp.7982-7999, 2023-11-22 - Ventral pallidal glutamatergic neurons regulate wakefulness and emotion through separated projections
Luo Yan-Jia; Ge Jing; Chen Ze-Ka; Liu Zi-Long; Lazaru...
ISCIENCE/26(8), 2023-08-18 - The role of extracellular adenosine in the basal ganglia for sleep-wake regulation
Lazarus Michael; Cherasse Yoan; Hiasa Miki; Chen Jian...
NEUROSCIENCE RESEARCH/68/pp.E8-E8, 2010 - A role for mDia, a Rho-regulated actin nucleator, in regulating morphology of presynaptic terminals and increased anxiety-like behavior induced by social isolation stress in mice
Deguchi Yuichi; Harada Masaya; Shinohara Ryota; Lazaru...
JOURNAL OF PHARMACOLOGICAL SCIENCES/128(3)/pp.S92-S92, 2015-07 - Parasubthalamic calretinin neurons modulate wakefulness associated with exploration in male mice
Guo Han; Jiang Jian-Bo; Xu Wei; Zhang Mu-Tian; Chen ...
NATURE COMMUNICATIONS/14(1), 2023-04 - Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice
Nishioka Tadaaki; Attachaipanich Suthinee; Hamaguchi K...
NATURE COMMUNICATIONS/14(1)/p.2284, 2023-04-21 - Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice
Lin Yang; Roy Koustav; Ioka Shuji; Otani Rintaro; Ame...
Frontiers in pharmacology/14, 2023-04-01 - Editorial: The Gating and Maintenance of Sleep and Wake: New Circuits and Insights
Lazarus Michael; Hayashi Yu; Honjoh Sakiko; Vogt Kasp...
Frontiers in neuroscience/14, 2020-04 - EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model
Tao Xixi; Zhang Rui; Du Ronglu; Yu Tingting; Yang Hu...
JOURNAL OF EXPERIMENTAL MEDICINE/219(5), 2022-04 - Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation
Ma Wei-Xiang; Yuan Ping-Chuan; Zhang Hui; Kong Ling-X...
FRONTIERS IN PHARMACOLOGY/14, 2023-04-01 - A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy
Chen Ze-Ka; Dong Hui; Liu Cheng-Wei; Liu Wen-Ying; Zh...
CELL DISCOVERY/8(1)/p.115, 2022-10-25 - PGE(2)-EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase
Tao Xixi; Du Ronglu; Guo Shumin; Feng Xiangling; Yu ...
EMBO JOURNAL/41(16), 2022-08 - Allosteric Modulation of Adenosine A(2A) Receptors as a New Therapeutic Avenue
Korkutata Mustafa; Agrawal Lokesh; Lazarus Michael
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES/23(4), 2022-02 - Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice
Takahashi Aki; Durand-de Cuttoli Romain; Flanigan Megh...
Nature communications/13(1)/p.4039, 2022-07-21 - Acute Social Defeat Stress Increases Sleep in Mice
Fujii Shinya; Kaushik Mahesh K; Zhou Xuzhao; Korkutata M...
Frontiers in neuroscience/13/p.322, 2019-04 - Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior
Li Ya-Dong; Luo Yan-Jia; Chen Ze-Ka; Quintanilla Luis...
NATURE NEUROSCIENCE/25(5)/pp.630-645, 2022-05-01 - Mesencephalic dopamine neurons are essential for modafinil-induced arousal
Yang Yan-Fei; Dong Hui; Shen Yan; Li Lei; Lazarus Mi...
BRITISH JOURNAL OF PHARMACOLOGY/178(24)/pp.4808-4825, 2021-12 - Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors
Tsai Chia-Jung; Nagata Takeshi; Liu Chih-Yao; Suganuma...
Cell reports/36(7)/p.109558, 2021-08 - さらに表示...
- Enhancement of Haloperidol-Induced Catalepsy by GPR143, an L-Dopa Receptor, in Striatal Cholinergic Interneurons
- 著書
- Adenosine A2A receptors and sleep
Korkutata Mustafa; Lazarus Michael
ADENOSINE A2A RECEPTOR ANTAGONISTS/ELSEVIER ACADEMIC PRESS INC/pp.155-178, 2023-04-01 - Adenosinergic Control of Sleep
Lazarus Michael; Oishi Yo; Landolt Hans-Peter
Principles and Practice of Sleep Medicine Seventh Edition/pp.452-459, 2021-12 - Adenosinergic Control of Sleep/Wake Behavior
Zhou Xuzhao; Lazarus Michael
HANDBOOK OF SLEEP RESEARCH, VOL 30/ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD/pp.125-136, 2019
- Adenosine A2A receptors and sleep
- 会議発表等
- The Teleological Mystery of Sleep — Glioneuronal Mechanisms Integrating Sleep Homeostasis and Motivation
LAZARUS Michael
CNS 2024– The 17th Annual Meeting of the Chinese Neuroscience Society/2024-09-26--2024-09-29 - Why are we sleepy when we are bored? Molecular links between sleep and motivation
LAZARUS Michael
第38回 日本大脳基底核研究会/2024-08-03--2024-08-04 - The teleological mystery of sleep ⎯ Glioneuronal mechanisms integrating sleep homeostasis and motivation
LAZARUS Michael
Glia Decoding International Symposium/2024-07-27--2024-07-28 - The neuroglial mechanisms underlying the gating of sleep homeostasis by motivation
LAZARUS Michael
第47回日本神経科学大会/2024-07-24--2024-07-27 - 睡眠の時空間制御を目指した遠隔操作薬の開発
斉藤 毅; Koustav Roy; 大谷 凛太朗; 井岡 秀二; Michael Lazarus
第18回GPCR研究会/2024-05-25--2024-05-26 - Glioneuronal mechanisms integrating sleep homeostasis and motivation
Lazarus Michael
ERATO UK-Japan Joint Symposium on Circadian Rhythms and Sleep/2024-03-11--2024-03-13 - The Teleological Mystery of Sleep - Glioneuronal Mechanisms Integrating Sleep Homeostasis and Motivation
Lazarus Michael
Gordon Research Conference “Sleep Regulation and Function/2024-03-03--2024-03-08 - Glioneuronal mechanisms integrating sleep homeostasis and motivation
Lazarus Michael
2023 Oriental International Sleep Medicine Summit ForumShanghai/2023-12-8--2023-12-10 - Why are we sleepy when we are bored? The gating of sleep homeostasis by motivation
Lazarus Michael
45th Annual Meeting of Japanese Society of Sleep Research/2023-09-15--2023-09-17 - Glioneuronal mechanisms integrating sleep homeostasis and motivation
Lazarus Michael
World Sleep 2023 – Congress of the World Sleep Society/2023-10-20--2023-10-25 - Glioneuronal mechanisms integrating sleep homeostasis and motivation
Lazarus Michael
CNS 2023 & CJK 2nd – The 16th Annual Meeting of the Chinese Neuroscience Society & The 2nd CJK International Meeting/2023-07-27--2023-07-30 - Why Are We Sleepy When we Are bored? - the Gating of Sleep Homeostasis by Motivation
Lazarus Michael
SLEEP 2023 – 37th Meeting of the Associated Sleep Societies/2023-06-03--2023-06-07 - Decoding the neuronal and glial regulation of sleep homeostasis by motivation in mice
Lazarus Michael
CSHA meeting on novel insights into glia function and dysfunction/2023-04-24--2023-04-27 - Why are we sleepy when we are bored? The gating of sleep homeostasis by motivation
Lazarus Michael
IPSA Online, 7th Congress of the International Pediatric Sleep Association (IPSA)/2022-10-27--2022-10-29 - Molecular mechanisms underlying the gating of sleep homeostasis by motivation
Lazarus Michael
The Nineteenth Conference of Peace through Mind/Brain Science/2023-02-21--2023-02-23 - Opto-chemical control of sleep in the nucleus accumbens using a photocaged adenosine A2A receptor allosteric modulator
Lazarus Michael
Photopharmacology III/2021-11-29--2021-11-30 - Why are we sleepy when bored? - The gating of sleep homeostasis by motivation
Lazarus Michael
5th Asian Forum on Chronobiology/2021-07-14--2021-07-19 - The gating of sleep homeostasis by motivation Why are we sleepy when bored?
Lazarus Michael
3rd Congress of the Asian Society of Sleep Medicine/2021-05-16 - Involvement the lateral habenul–dorsal raphe nucleus–ventral tegmental area projection in social instigation-heightened aggression in male mice
Takahashi Aki
Neuroscience 2021/2021-11-08--2021-11-11 - Glutamatergic projection from the lateral habenula to the dorsal raphe nucleus escalates aggressive behavior of male mice.
Takahashi Aki; Flanigan Meghan E; Tsunematsu Tomomi; Al...
第44回日本神経科学大会/CJK第1回国際会議/2021-07-28--2021-07-31 - The gating of sleep by motivated behavior
Lazarus M.
24th Congress of the European-Sleep-Research-Society (ESRS)/2018-09-25--2018-09-28 - A nucleus accumbens circuit in control of sleep
Lazarus Michael
4th International Pediatric Sleep Association Congress/2016-03-10--2016-03-13 - Why do we fall asleep when bored? − A nucleus accumbens circuit in control of sleep
Lazarus Michael
日本睡眠学会第41回定期学術集会/2016-07-07--2016-07-08 - The link between REM sleep loss and the desire for junk food
Lazarus Michael
International Symposium on LIVING IN SPACE 2017/2017-03-09--2017-03-09 - The waking, sleeping and dreaming brain: New circuits and insights
Lazarus Michael
World Sleep 2017 – 1st Congress of the World Sleep Society/2017-10-07--2017-10-11 - さらに表示...
- The Teleological Mystery of Sleep — Glioneuronal Mechanisms Integrating Sleep Homeostasis and Motivation
- 担当授業科目
2024-04 -- 2024-08 ヒューマニクス基礎実験 IIIa 筑波大学 2024-10 -- 2025-02 ヒューマニクス演習 IIIb 筑波大学 2024-10 -- 2025-02 ヒューマンバイオロジー基礎実験 筑波大学 2024-10 -- 2025-02 感性認知脳科学特講4 筑波大学 2024-04 -- 2024-08 感性認知脳科学特講4 筑波大学 2024-04 -- 2024-08 ヒューマンバイオロジー演習I 筑波大学 2024-10 -- 2025-02 ヒューマニクス特論 IIIb 筑波大学 2024-04 -- 2024-08 ヒューマニクス特論 IIIa 筑波大学 2024-04 -- 2024-08 ヒューマニクス演習 IIIa 筑波大学 2024-10 -- 2025-02 感性認知脳科学特講6 筑波大学 さらに表示... - 一般講演
- Glioneuronal mechanisms integrating sleep homeostasis and motivation
LAZARUS Michael
4th IBRO Neuroscience School Nepal 2024/2024-04-29--2024-04-29 - Why are we sleepy when we are bored? The gating of sleep homeostasis by motivation
Lazarus Michael
Technical University Dresden CMCB Life Sciences Seminar/2022-09-22 - The gating of sleep homeostasis by motivation
Lazarus Michael
大阪大学第8回子どものこころの 分子統御機構研究センター連続セミナー/2021-12-14 - Why are we sleepy when we are bored? The gating of sleep homeostasis by motivation
Lazarus Michael
大阪大学蛋白質研究所セミナー “多様なドーパミン神経伝達から脳を探る”/2021-12-13
- Glioneuronal mechanisms integrating sleep homeostasis and motivation
- 学協会等委員
2023-04 -- 2026-03 日本神経科学学会 評議員 - メッセージ
-
睡眠研究に興味のある学生を歓迎します。
(最終更新日: 2024-10-21)