HENGPHASATPORN KOWIT(ヘンパサトポン コビット)
- 所属
- 計算科学研究センター
- 職名
- 助教
- ORCID
- 0000-0001-8501-3844
- eメール
- G$(0"-!<KGzz,E-,.$.yxExzE#)B
- 研究分野
生体関連化学 生物分子化学 分子生物学 進化生物学 - 研究キーワード
Drug discovery and design Molecular Dynamics Simulation - 職歴
2022-04 -- (現在) 筑波大学計算科学研究センター助教 2019-09 -- 2022-03 筑波大学計算科学研究センター研究員 - 取得学位
2019 Doctor of Philosophy (Ph.D.) in Bioinformatics and Computational Biology Chulalongkorn University - 所属学協会
2022 -- (現在) 日本蛋白質科学会 2022 -- (現在) 日本生物物理学会 - 論文
- Machine learning-guided design of potent darunavir analogs targeting HIV-1 proteases: A computational approach for antiretroviral drug discovery
Chuntakaruk Hathaichanok; Boonpalit Kajjana; Kinchagawa...
Journal of computational chemistry, 2024-01-04 - Structural and thermodynamic insights into antibody light chain tetramer formation through 3D domain swapping
Sakai Takahiro; Mashima Tsuyoshi; Kobayashi Naoya; Oga...
Nature communications/14(1)/p.7807, 2023-12-08 - A sulfonamide chalcone inhibited dengue virus with a potential target at the SAM-binding site of viral methyltransferase
Cao Van; Sukanadi I Putu; Loeanurit Naphat; Suroengrit...
Antiviral research/220, 2023-12-01 - Synthesis and biological evaluation of 2'-hydroxychalcone derivatives as AMPK activators
Vu Nguyen Duy; Muanprasat Chatchai; Kaewin Suchada; He...
Bioorganic chemistry/143, 2023-12-21 - Structure-yeast α-glucosidase inhibitory activity relationship of 9-O-berberrubine carboxylates
Nguyen Duy Vu; Hengphasatporn Kowit; Danova Ade; Suroe...
Scientific reports/13(1), 2023-11-01 - Identification of Promising Sulfonamide Chalcones as Inhibitors of SARS-CoV-2 3CLpro through Structure-Based Virtual Screening and Experimental Approaches
Pojtanadithee Piyatida; Hengphasatporn Kowit; Suroengri...
JOURNAL OF CHEMICAL INFORMATION AND MODELING/Epub, 2023-08-15 - A Structural Refinement Technique for Protein-RNA Complexes Based on a Combination of AI-based Modeling and Flexible Docking: A Study of Musashi-1 Protein
Hengphasatporn Kowit; Darai Nitchakan; Wolschann Peter...
Bulletin of The Chemical Society of Japan, 2023-6-23 - A novel flavanone derivative inhibits dengue virus fusion and infectivity
Srivarangkul Pimsiri; Yuttithamnon Wanchalerm; Suroengr...
Antiviral research/151/pp.27-38, 2018-03-01 - Cardol triene inhibits dengue infectivity by targeting kl loops and preventing envelope fusion
Kanyaboon Parichat; Saelee Thanaphon; Suroengrit Aphin...
Scientific reports/8(1), 2018-11-09 - Interaction of 8-anilinonaphthalene-1-sulfonate with SARS-CoV-2 main protease and its application as a fluorescent probe for inhibitor identification
Deetanya Peerapon; Hengphasatporn Kowit; Wilasluck Pat...
Computational and structural biotechnology journal/19/pp.3364-3371, 2021-04-01 - Design, synthesis, in vitro, in silico, and SAR studies of flavone analogs towards anti-dengue activity
Patigo Apinya; Hengphasatporn Kowit; Cao Van; Paunrat ...
SCIENTIFIC REPORTS/12(1), 2022-12-14 - Lichen-Derived Diffractaic Acid Inhibited Dengue Virus Replication in a Cell-Based System
Loeanurit Naphat; Tuong Truong Lam; Nguyen Van-Kieu; V...
Molecules (Basel, Switzerland)/28(3), 2023-01-18 - N-Containing alpha-Mangostin Analogs via Smiles Rearrangement as the Promising Cytotoxic, Antitrypanosomal, and SARS-CoV-2 Main Protease Inhibitory Agents
Pyae Nan Yadanar Lin; Maiuthed Arnatchai; Phongsopitanu...
Molecules (Basel, Switzerland)/28(3), 2023-01-22 - X-ray crystallographic and mutational analysis of the NylC precursor: catalytic mechanism of autocleavage and substrate hydrolysis of nylon hydrolase
Negoro Seiji; Shibata Naoki; Kato Dai-Ichiro; Tanaka ...
FEBS JOURNAL/290(13)/pp.3400-3421, 2023-07-01 - In silico screening of chalcones and flavonoids as potential inhibitors against yellow head virus 3C-like protease
Boonthaworn Kanpong; Hengphasatporn Kowit; Shigeta Yas...
PEERJ/11, 2023-04-01 - The 8-bromobaicalein inhibited the replication of dengue, and Zika viruses and targeted the dengue polymerase
Boonyasuppayakorn Siwaporn; Saelee Thanaphon; Huynh Th...
SCIENTIFIC REPORTS/13(1)/p.7651, 2023-03-25 - Sulfonylated Indeno[1,2-c]quinoline Derivatives as Potent EGFR Tyrosine Kinase Inhibitors
Hengphasatporn Kowit; Aiebchun Thitinan; Mahalapbutr P...
ACS OMEGA/8(22)/pp.19645-19655, 2023-06-06 - 中分子の膜透過性に対する計算手法の検討
高橋 輝行; Hengphasatporn Kowit; 原田 隆平; 重田 育照
JCPE Journal/21(4)/pp.118-122, 2022 - 抗体軽鎖四量体の立体構造の理論解析
Lian Duan; Hengphasatporn Kowit; 重田 育照
JCPE Journal/21(4)/pp.123-125, 2022 - Designing Potent α-Glucosidase Inhibitors: A Synthesis and QSAR Modeling Approach for Biscoumarin Derivatives
Phan Thi-Hong-Truc; Hengphasatporn Kowit; Shigeta Yasu...
ACS OMEGA/8(29)/pp.26340-26350, 2023-07-25 - Determination of the Association between Mesotrione Sensitivity and Conformational Change of 4-Hydroxyphenylpyruvate Dioxygenase via Free-Energy Analyses
Munei Yohei; Hengphasatporn Kowit; Hori Yuta; Harada ...
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY/71(24)/pp.9528-9537, 2023-06-21 - Promising SARS-CoV-2 main protease inhibitor ligand-binding modes evaluated using LB-PaCS-MD/FMO
Hengphasatporn Kowit; Harada Ryuhei; Wilasluck Patcharin...
SCIENTIFIC REPORTS/12(1), 2022-10-26 - Pharmacophore-Based Virtual Screening and Experimental Validation of Pyrazolone-Derived Inhibitors toward Janus Kinases
Sanachai Kamonpan; Mahalapbutr Panupong; Hengphasatporn...
ACS OMEGA/7(37)/pp.33548-33559, 2022-09 - 4-hydroxyphenylpyruvate dioxygenase (HPPD)における金属活性中心の力場パラメータの構築とその評価
宗井 陽平; 堀 優太; Kowit Hengphasatporn; 原田 隆平; 重田 育照
The Journal of Computer Chemistry, Japan/21(4)/pp.82-84, 2023-03 - Supramolecular polymerization of thiobarbituric acid naphthalene dye
Aizawa Takumi; Kawaura Maika; Kajitani Takashi; Hengph...
CHEMICAL COMMUNICATIONS/58(67)/pp.9365-9368, 2022-08 - さらに表示...
- Machine learning-guided design of potent darunavir analogs targeting HIV-1 proteases: A computational approach for antiretroviral drug discovery
- 会議発表等
- 分子動力学シミュレーションによるがん原因融合タンパク質SS18-SSXのC末端結合領域とヌクレオソームの相互作用解析
小淵 里恵; 段 炼; Kowit Hengphasatporn; 重田 育照; 谷 一寿; 鈴木 理...
第46回日本分子生物学会年会/2023-12-06--2023-12-08 - SOD1のCYS酸化に伴う構造変化の理論的研究
佐藤 綾香; 藤木 涼; 堀 優太; Hengphasatporn Kowit; 重田 育照
日本コンピュータ化学会2023年/2023-11-24--2023-11-26 - 天然変性タンパク質が滑膜肉腫発生の原因となる仕組み
韓 叡佳; 堀越直樹; 高橋花南; 谷一寿; 宮ノ入洋平; 中本佳歩; 古寺哲幸; Kowit Hengpha...
第96回日本生化学会大会/2023-10-31--2023-11-2 - FMO-Guided Design of Darunavir Analogs as HIV-1 Protease Inhibitors
Hengphasatporn Kowit
the 5th Congress of the Theory and Applications of Computational Chemistry (TACC2023)/2023-09-5--2023-9-9 - Combining AI-based Modeling and Flexible Docking for Efficient Refinement of Protein-RNA Complexes using PaCS-MD
Hengphasatporn Kowit
The Protein Society - 37th Annual Symposium/2023-07-13--2023-07-16 - 多分野融合によるアミロイド類縁腎臓疾患のメカニズム解析
HENGPHASATPORN KOWIT
第40回分子病理学研究会クラークシンポジウム/2023-7-14--2023-7-15 - 中分子の膜透過性に対する計算手法の検討
HENGPHASATPORN KOWIT
日本コンピューター化学会 2022年 秋季年会/2022-11-25--2022-11-27 - 光合成水分解酸素発生におけるMnの自然選択の理由
HENGPHASATPORN KOWIT
量子生命科学会第4回大会/2022-05-26--2022-05-27 - Evaluation of brominated baicalein as a promising SARs-CoV-2 Mpro Inhibitor
Hengphasatporn Kowit
物性研短期研究会「理論タンパク質物性科学の最前線:理論と実験との密な協働/2022-07-26--2022-07-27 - Evaluation of the Potent SARS-CoV-2 Main Protease Inhibitors using LB-PaCS-MD/FMO Technique
Hengphasatporn Kowit
The 60th Annual Meeting of the Biophysical Society of Japan/2022-08-28--2022-08-30 - Estimation of acid dissociation constants (pKa) of N-containing heterocycles in DMSO and transferability of Gibbs free energy in various solvent conditions
Hengphasatporn Kowit
The 6th Asian Workshop on Molecular Spectroscopy(AWMS 2022)/2022-11-3--2022-11-4 - Integrated Simulation for Antiviral Drug Discovery and Design
HENGPHASATPORN KOWIT
The 22nd Annual Meeting of the Protein Science Society of Japan/2023-07-07--2023-07-09 - Ligand-Binding Mode Evaluation of Potential SARS-CoV-2 Main Protease Inhibitors: LB-PaCS-MD/FMO method
HENGPHASATPORN KOWIT
The 25th International Annual Symposium on Computational Science and Engineering (ANSCSE)/2022-07-06--2022-07-09 - Exploring Antiviral Drug Discovery through Computational Calculations and Fragment Molecular Orbital (FMO) Method
HENGPHASATPORN KOWIT
CCS – LBNL Collaborative Workshop 2023/2023-04-12--2023-04-13 - Integration between ML and Cheminformatics
Hengphasatporn Kowit
ML-based 3D QSAR for drug discovery and design Workshop 2023/2023-02-08--2023-02-11 - Halogenated compound as a promising antiviral using FMO calculation
HENGPHASATPORN KOWIT
凝縮系の理論化学 2023/2023-03-9--2023-03-10 - Computer-Aided Drug Design (CADD) for Antiviral Research
Hengphasatporn Kowit
AMED e-ASIA/JSPS KAKENHI/JSPS Bilateral Programs/TIA KAKEHASHI Joint Symposium/2023-03-6--2023-03-8 - 中分子の膜透過性に対する計算手法の検討
高橋 輝行; HENGPHASATPORN KOWIT; 原田 隆平; 重田 育照
日本コンピューター化学会 2022年 秋季年会/2022-11-27 - 分子動力学計算に基づくシロイヌナズナおよび エンバクHPPD-メソトリオン複合体の結合挙動解析
宗井 陽平; 堀 優太; HENGPHASATPORN KOWIT; 原田 隆平; 重田 育照
日本コンピューター化学会 2022年 秋季年会/2022-11-26 - 天然変性領域SSXとSMARCB1 c末端 α-ヘリックスによる競合的なヌクレオソーム酸性パッチターゲッティング
鈴木 理惠; 高橋 花南; 堀越 直樹; 小淵 里恵; 重田 育照; Kowit Hengphasatporn; ...
第23回日本蛋白質科学会年会/2023-07-05--2023-07-07 - ヒト型アルギニンメチル化酵素PRMT1遺伝子改変マウスの作出とその解析
姚遠; 加香孝一郎; Kowit Hengphasatporn; 重田育照; 本村香織; 金俊達; 深水 昭吉
第95回日本生化学会会/2022-11-09 - 分子動力学計算に基づくシロイヌナズナおよびエンバクHPPD-メソトリオン複合体の結合挙動解析
宗井 陽平; 堀 優太; Hengphasatporn Kowit; 原田 隆平; 重田 育照
日本コンピュータ化学会2022年秋季年会/2022-11-25--2022-11-27
- 分子動力学シミュレーションによるがん原因融合タンパク質SS18-SSXのC末端結合領域とヌクレオソームの相互作用解析
(最終更新日: 2024-01-09)