斉藤 毅(サイトウ ツヨシ)
- 論文
- Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor
Yamamoto Naoshi; Ohrui Sayaka; Okada Takahiro; Yata Masa...
Bioorganic & medicinal chemistry letters/27(17)/pp.4176-4179, 2017-09 - Synthesis of heterocyclic compounds with adamantane-like cage structures consisting of phosphorus, sulfur, and carbon
Kutsumura Noriki; Ohshita Ryuichiro; Horiuchi Jumpei; Tat...
TETRAHEDRON/73(34)/pp.5214-5219, 2017-08 - Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives
Kutsumura Noriki; Koyama Yasuaki; Nagumo Yasuyuki; Nakaji...
Bioorganic & medicinal chemistry/25(16)/pp.4375-4383, 2017-08 - IIIS 発 ナルコレプシー治療薬開発に向けた取り組み
⻫藤 毅; 入鹿山 容子; 柳沢 正史; ⻑瀬 博
なるこ/(34)/pp.8-10, 2017-05 - Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models.
Y Irukayama-Tomobe; Y Ogawa; H Tominaga; Y Ishikawa; N H...
Proc Natl Acad Sci U S A., 2017-05 - Click Reaction Based on the Biosynthesis of Firefly Luciferin
Toyama Tomohisa; Saitoh Tsuyoshi; Takahashi Yuka; Oka Ko...
CHEMISTRY LETTERS/46(5)/pp.753-755, 2017-05 - A small molecule orexin receptor agonist promotes recovery from inflammation-induced immobility
Uchida Shuntaro; Irukayama Yoko; Ogawa Yasuhiro; Tominaga...
JOURNAL OF PHARMACOLOGICAL SCIENCES/133(3)/p.S163, 2017-03 - Histological and electrophysiological analysis of a small-molecule OX2R-slective agonist YNT-185
Ogawa Yasuhiro; Irukayama Yoko; Tominaga Hiromu; Hosokawa...
JOURNAL OF PHARMACOLOGICAL SCIENCES/133(3)/p.S163, 2017-03 - Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies
Nagase Hiroshi; Yamamoto Naoshi; Yata Masahiro; Ohrui Sa...
JOURNAL OF MEDICINAL CHEMISTRY/60(3)/pp.1018-1040, 2017-02 - Asymmetric induction in cyclohexadienones carrying α-d-glucopyranosyl moiety
Yajima Saki; Saitoh Tsuyoshi; Kawa Kohei; Nakamura Kensu...
Tetrahedron/72(51)/pp.8428-8435, 2016-12 - Development of a luminescence-controllable firefly luciferin analogue using selective enzymatic cyclization
Ioka Shuji; Saitoh Tsuyoshi; Maki Shojiro A.; Imoto Masaya; N...
TETRAHEDRON/72(47)/pp.7505-7508, 2016-11 - 睡眠覚醒を制御する世界初の分子:オレキシン2受容体作動薬 YNT-185 の創製
斉藤 毅; 長瀬 博
和光純薬時報/84(3)/pp.2-5, 2016-07 - Synthesis of Firefly Luciferin Analogues and Evaluation of the Luminescent Properties
Ioka Shuji; Saitoh Tsuyoshi; Iwano Satoshi; Suzuki Koji; ...
<i>Chemistry, A European Journal<i/>/22(27)/pp.9330-9337, 2016-06 - 低分子オレキシン受容体アゴニストの創製
斉藤 毅; 長瀬 博
MEDCHEM NEWS/26(2)/pp.90-96, 2016 - YNT-185, a novel small-molecule orexin type 2 receptor agonist, ameliorates narcolepsy- cataplexy symptoms in model mice
Saito Tsuyoshi
JOURNAL OF PHARMACOLOGICAL SCIENCES/130(3)/p.S138, 2016-03 - Investigation of 7-benzylidenenaltrexone derivatives as a novel structural antitrichomonal lead compound
Kutsumura Noriki; Nakajima Ryo; Koyama Yasuaki; Miyata Yoshi...
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS/25(21)/pp.4890-4892, 2015-11 - Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists
Nagahara Takashi; Saitoh Tsuyoshi; Kutsumura Noriki; Irukaya...
JOURNAL OF MEDICINAL CHEMISTRY/58(20)/pp.7931-7937, 2015-10 - Cathodic reductive coupling of methyl cinnamate on boron-doped diamond electrodes and synthesis of new neolignan-type products
Kojima Taiki; Obata Rika; Saito Tsuyoshi; Einaga Yasu...
Beilstein Journal of Organic Chemistry/11/pp.200-203, 2015-02 - Bioluminescent coelenterazine derivatives with imidazopyrazinone C-6 extended substitution
Nishihara Ryo; Suzuki Hideyuki; Hoshino Emi; Suganuma Sa...
Chemical Communications/51(2)/pp.391-394, 2014-11 - 超原子価ヨードベンゼンを活用した含窒素天然物の合成
斉藤 毅; 西山 繁
有機合成化学協会誌/72(10)/pp.1120-1130, 2014-10 - Synthesis and assignment of the absolute stereochemistry of (+)-hemifistularin 3
Kubo Hironori; Matsui Kaori; Saitoh Tsuyoshi; Nishiyama ...
TETRAHEDRON/70(37)/pp.6392-6397, 2014-09 - Sequential paired electrosynthesis of a diary ether derivative using an electrochemical micro reactor
Kashiwagi Tsuneo; Fuchigami Toshio; Saito Tsuyoshi; Nishiyam...
CHEMISTRY LETTERS/43(6)/pp.799-801, 2014-06 - オレキシン受容体を標的とした不眠症治療薬の可能性
斉藤 毅
ファルマシア/50(1)/pp.69-69, 2014 - Glycosylation of a Newly Functionalized Orthoester Derivative
Saito Tsuyoshi; Kawa Kohei; Kaji Eisuke; Nishitama Shigeru
Molecules/19(2)/pp.2602-2611, 2014-02 - Synthesis of (+)-O-Methylthalibrine Employing a Stereocontrolled Bischler-Napieralski Reaction and an Electrochemically Generated Diaryl Ether
Kawabata Yuki; Naito Yu; Saitoh Tsuyoshi; Kawa Kohei; Fuc...
Eur. J. Org. Chem./2014(1)/pp.99-104, 2013-11 - さらに表示...
- Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor