関谷 元博(セキヤ モトヒロ)

研究者情報全体を表示

論文
  • Malondialdehyde-modified LDL-related variables are　 associated with diabetic kidney disease in type 2 diabetes.
    S Furukawa; H Suzuki; K Fujihara; K Kobayashi; H Iwasaki...
    Diabetes Res Clin Pract./141/pp.237-243, 2018-05
    PubMed Tsukuba Repository
  • Transgenic mice overexpressing SREBP-1a in male ob/ob mice exhibit lipodystrophy and exacerbate insulin resistance
    Ohno Hiroshi; Matsuzaka Takashi; Tang Nie; Sharma Rahul; ...
    Endocrinology/159(6)/pp.2308-2323, 2018-06
    PubMed
  • Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry
    Sawada Yoshikazu; Izumida Yoshihiko; Takeuchi Yoshinori; ...
    Biochemical and biophysical research communications/493(1)/pp.40-45, 2017-09
    PubMed
  • Elimination of cholesterol ester from macrophage foam cells by adenovirus-mediated gene transfer of hormone-sensitive lipase.
    H Okazaki; J Osuga; K Tsukamoto; N Isoo; T Kitamine; Y T...
    J Biol Chem., 2002-8
    PubMed
  • FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products.
    Y Tamura; H Adachi; J Osuga; K Ohashi; N Yahagi; Sekiya ...
    J Biol Chem., 2003-4
    PubMed
  • FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products.
    Sekiya Motohiro
    J Biol Chem., 2003-4
    PubMed
  • Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.
    T Yoshikawa; T Ide; H Shimano; N Yahagi; M Amemiya-Kudo; ...
    Mol Endocrinol., 2003-7
  • p53 Activation in adipocytes of obese mice.
    N Yahagi; H Shimano; T Matsuzaka; Y Najima; Sekiya Motoh...
    J Biol Chem., 2003-7
    PubMed
  • Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene.
    K Ohashi; J Osuga; R Tozawa; T Kitamine; H Yagyu; Sekiya ...
    J Biol Chem., 2003-10
    PubMed
  • Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression.
    Sekiya Motohiro; N Yahagi; T Matsuzaka; Y Najima; M Naka...
    Hepatology, 2003-12
    PubMed
  • Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep ob/ob mice.
    Sekiya Motohiro; J Osuga; H Okazaki; N Yahagi; K Harada; ...
    J Biol Chem, 2004-4
    PubMed
  • Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.
    H Okazaki; F Tazoe; S Okazaki; N Isoo; K Tsukamoto; Sekiy...
    J Lipid Res., 2006-9
    PubMed
  • Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis.
    H Okazaki; M Igarashi; M Nishi; M Tajima; Sekiya Motohir...
    Diabetes., 2006-6
    PubMed
  • Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis.
    H Okazaki; M Igarashi; M Nishi; Sekiya Motohiro; M Tajima
    J Lipid Res., 2008-08
  • Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages.
    H Okazaki; M Igarashi; M Nishi; Sekiya Motohiro; M Tajima
    J Biol Chem., 2008-11
    PubMed
  • Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence.
    Sekiya Motohiro
    J Lipid Res, 2010-02
    PubMed
  • Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.
    Sekiya Motohiro; J Osuga; S Nagashima; T Ohshiro; M Igar...
    Cell Metab., 2009-09
  • The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages.
    M Igarashi; J Osuga; H Uozaki; Sekiya Motohiro; S Nagash...
    Circ Res., 2010-11
    PubMed
  • Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement.
    Commun. Biochem Biophys Res; Sekiya Motohiro; H Uozaki; M...
    Biochem Biophys Res Commun., 2011-01
  • The role of neutral cholesterol ester hydrolysis in macrophage foam cells.
    Sekiya Motohiro; Osuga J; Igarashi M; Okazaki H; Ishibash...
    J Atheroscler Thromb., 2011-04
    PubMed
  • Sterol regulatory element-binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor-deficient mice.
    T Karasawa; A Takahashi; R Saito; Sekiya Motohiro; M Iga...
    Arterioscler Thromb Vasc Biol, 2011-08
    PubMed
  • Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death.
    Sekiya Motohiro
    Arterioscler Thromb Vasc Biol, 2012-8
  • Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene.
    Takase S; Osuga J; Fujita H; Hara K; Sekiya Motohiro; Iga...
    J Atheroscler Thromb., 2013-3
    PubMed
  • Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production.
    Sekiya Motohiro
    Cell Metab, 2013-5
    PubMed
  • Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.
    Sekiya Motohiro
    J Lipid Res, 2014-10
    PubMed
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