関谷 元博(セキヤ モトヒロ)
- 論文
- Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression.
Sekiya Motohiro; N Yahagi; T Matsuzaka; Y Najima; M Naka...
Hepatology, 2003-12 - Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep ob/ob mice.
Sekiya Motohiro; J Osuga; H Okazaki; N Yahagi; K Harada; ...
J Biol Chem, 2004-4 - Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.
H Okazaki; F Tazoe; S Okazaki; N Isoo; K Tsukamoto; Sekiy...
J Lipid Res., 2006-9 - Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis.
H Okazaki; M Igarashi; M Nishi; M Tajima; Sekiya Motohir...
Diabetes., 2006-6 - Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis.
H Okazaki; M Igarashi; M Nishi; Sekiya Motohiro; M Tajima
J Lipid Res., 2008-08 - Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages.
H Okazaki; M Igarashi; M Nishi; Sekiya Motohiro; M Tajima
J Biol Chem., 2008-11 - Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence.
Sekiya Motohiro
J Lipid Res, 2010-02 - Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.
Sekiya Motohiro; J Osuga; S Nagashima; T Ohshiro; M Igar...
Cell Metab., 2009-09 - The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages.
M Igarashi; J Osuga; H Uozaki; Sekiya Motohiro; S Nagash...
Circ Res., 2010-11 - Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement.
Commun. Biochem Biophys Res; Sekiya Motohiro; H Uozaki; M...
Biochem Biophys Res Commun., 2011-01 - The role of neutral cholesterol ester hydrolysis in macrophage foam cells.
Sekiya Motohiro; Osuga J; Igarashi M; Okazaki H; Ishibash...
J Atheroscler Thromb., 2011-04 - Sterol regulatory element-binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor-deficient mice.
T Karasawa; A Takahashi; R Saito; Sekiya Motohiro; M Iga...
Arterioscler Thromb Vasc Biol, 2011-08 - Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death.
Sekiya Motohiro
Arterioscler Thromb Vasc Biol, 2012-8 - Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene.
Takase S; Osuga J; Fujita H; Hara K; Sekiya Motohiro; Iga...
J Atheroscler Thromb., 2013-3 - Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production.
Sekiya Motohiro
Cell Metab, 2013-5 - Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.
Sekiya Motohiro
J Lipid Res, 2014-10 - Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.
Nagashima S; Yagyu H; Tozawa R; Tazoe F; Takahashi M; Kit...
J Lipid Res., 2015-5 - Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.
Sekiya Motohiro; MF Burak; KE Inouye; A White; G Tuncman...
Sci Transl Med, 2015-12 - Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice
Takei Kenta; Nakagawa Yoshimi; Wang Yunong; Han Song-...
Journal of pharmacological sciences/133(4)/pp.214-222, 2017-04
- Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression.