Shiraki Kentaro
- Affiliation
- Institute of Pure and Applied Sciences
- Official title
- Professor
- URL
- Research keywords
Solution effect Additives in protein solution Viscosity of protein solution Stabilization of antibody Liquid-liquid phase separation Protein folding Control of enzyme reaction Phasing biology Protein solution Protein aggregation more... - Research projects
アミロイド形成を理解する相分離仮説の実証と共溶質の開発 2022 -- 2023 白木 賢太郎 Japan Society for the Promotion of Science/Grant-in-Aid for Challenging Research (Exploratory) 6,500,000Yen 液-液相分離によるタンパク質安定化技術の開発 2019 -- 2020 白木 賢太郎 Japan Society for the Promotion of Science/Grant-in-Aid for Challenging Research (Exploratory) 6,500,000Yen タンパク質液-液相分離の低分子コントロール 2018 -- 2020 白木 賢太郎 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B) 17,810,000Yen タンパク質の凝集や失活を防ぐ高分子アディティブの開発 2011 -- 2013 Japan Society of for the Promotion of Science/基盤研究(C) 3,770,000Yen タンパク質の凝集や失活をふせぐ溶液デザイン法の確立 2006 -- 2007 Japan Society of for the Promotion of Science/若手研究(B) 3,800,000Yen タンパク質凝集を抑制する小分子の探索 2005 -- (current) Japan Society of for the Promotion of Science/若手研究(B) 400,000Yen - Career history
1996-04 -- 1999-03 JSPSResearch Fellow 1999-04 -- 2001-07 CRESTPost Doctral Fellow 2001-08 -- 2004-08 Japan Advanced Institute of Science and TechnologyAssociate 2004-09 -- 2007-03 University of TsukubaInstitute of Applied PhysicsAssociate Professor 2007-04 -- 2016-11 University of TsukubaFaculty of Pure and Applied SciencesAssociate Professor 2016-12 -- (current) University of TsukubaFaculty of Pure and Applied SciencesProfessor - Academic background
-- 1994-03 Osaka University Faculty of Science Department of Biology -- 1999-03 Osaka University Graduate School of Science Department of Biochemistry - Degree
Ph. D. Osaka University - Academic societies
-- (current) Chemical Society of Japan -- (current) PROTEIN SCIENCE SOCIETY OF JAPAN - Articles
- Synthesis of Butterfly-like Shape Gold Nanomaterial: For the Regulation of Liquid–Liquid Phase-Separated Biomacromolecule Droplets
延山智弘; Tanaka Koji; Mori Megumi; Murakami Tatsuya; Yama...
Small, 2023/8/18 - Proteome analysis of high affinity mouse saliva proteins to hydroxyapatite
Ohshima Keijiro; Ohshima Tomoko; Meyer Karen; Takai E...
HELIYON/8(8), 2022-08 - Affinity of phenolic compounds for transition metal ions immobilized on cation-exchange columns
Ura Tomoto; Kameda Tomoshi; Laksmi Fina A.; Ishibashi ...
JOURNAL OF CHROMATOGRAPHY A/1676, 2022-08 - Arginine and its Derivatives Suppress the Opalescence of an Antibody Solution
Oki Shogo; Nishinami Suguru; Nakauchi Yoshitaka; Ogura...
JOURNAL OF PHARMACEUTICAL SCIENCES/111(4)/pp.1126-1132, 2022-04 - Differences in interaction lead to the formation of different types of insulin amyloid
Mori Wakako; Kawakami Ryosuke; Niko Yosuke; Haruta To...
SCIENTIFIC REPORTS/12(1), 2022-05 - Solution design to extend the pH range of the pH-responsive precipitation of a CspB fusion protein
Nagano Hayato; Mannen Teruhisa; Kikuchi Yoshimi; Shira...
PROTEIN EXPRESSION AND PURIFICATION/195, 2022-08 - Damage-free evaluation of cultured cells based on multivariate analysis with a single-polymer probe
Sugai Hiroka; Tomita Shunsuke; Ishihara Sayaka; Shiraki ...
Chemical Communications/58(79)/pp.11083-11086, 2022-10 - Opalescence Arising from Network Assembly in Antibody Solution
Nakauchi Yoshitaka; Nishinami Suguru; Murakami Yusuke; ...
MOLECULAR PHARMACEUTICS/19(4)/pp.1160-1167, 2022-04 - Lowering the viscosity of a high-concentration antibody solution by protein-polyelectrolyte complex
Tsumura Keisuke; Hsu WeiLin; Mimura Masahiro; Horiuchi...
JOURNAL OF BIOSCIENCE AND BIOENGINEERING/133(1)/pp.17-24, 2022-01 - Classification of protein solubilizing solutes by fluorescence assay
Nishinami Suguru; Arakawa Tsutomu; Shiraki Kentaro
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES/203/pp.695-702, 2022-04 - Dynamic behavior of liquid droplets with enzyme compartmentalization triggered by sequential glycolytic enzyme reactions
Ura Tomoto; Tomita Shunsuke; Shiraki Kentaro
CHEMICAL COMMUNICATIONS/57(93)/pp.12544-12547, 2021-11 - Insight into the protein salting-in mechanism of arginine, magnesium chloride and ethylene glycol: Solvent interaction with aromatic solutes
Ura Tomoto; Arakawa Tsutomu; Shiraki Kentaro
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES/188/pp.670-677, 2021-10 - Quadruplex Folding Promotes the Condensation of Linker Histones and DNAs via Liquid-Liquid Phase Separation
Mimura Masahiro; Tomita Shunsuke; Shinkai Yoichi; Hoso...
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY/143(26)/pp.9849-9857, 2021-07 - Aromatic interaction of hydantoin compounds leads to virucidal activities
Nishinami Suguru; Ikeda Keiko; Nagao Tamiko; Koyama A...
BIOPHYSICAL CHEMISTRY/275, 2021-08 - Aggregation of hen egg white proteins with additives during agitation
Hong Taehun; Iwashita Kazuki; Han Jeungmin; Nishinami ...
LWT-FOOD SCIENCE AND TECHNOLOGY/146, 2021-07 - Glass-like protein condensate for the long-term storage of proteins
Nakauchi Yoshitaka; Nishinami Suguru; Shiraki Kentaro
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES/182/pp.162-167, 2021-07 - Solubility Parameters of Amino Acids on Liquid-Liquid Phase Separation and Aggregation of Proteins
Nomoto Akira; Nishinami Suguru; Shiraki Kentaro
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY/9, 2021-06 - 1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells
Itoh Yuji; Iida Shiori; Tamura Sachiko; Nagashima Ryo...
Life science alliance/4(4), 2021-04 - Phasing Biology Reveals the Role of Prion Protein
西奈美 卓; 白木 賢太郎
Butsuri/75(4)/pp.192-200, 2020 - Detection of boson peak and fractal dynamics of disordered systems using terahertz spectroscopy
Mori Tatsuya; Jiang Yue; Fujii Yasuhiro; Kitani Sugur...
PHYSICAL REVIEW E/102(2), 2020-08 - Effect of additives on liquid droplets and aggregates of proteins
Shiraki Kentaro; Mimura Masahiro; Nishinami Suguru; Ur...
Biophysical reviews/12(2)/pp.587-592, 2020-04 - Arginine is a disease modifier for polyQ disease models that stabilizes polyQ protein conformation
Minakawa Eiko N; Popiel Helena Akiko; Tada Masayoshi; ...
Brain : a journal of neurology/143(6)/pp.1811-1825, 2020-06 - Terahertz Spectroscopy on Myoglobin: Boson Peak and Fracton
Mori Tatsuya; Motoji Leona; Fujii Yasuhiro; Kitani Sugur...
2019 44th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz), 2019-10 - Optical Fingerprints of Proteases and Their Inhibited Complexes Provided by Differential Cross-Reactivity of Fluorophore-Labeled Single-Stranded DNA
Tomita Shunsuke; Sugai Hiroka; Mimura Masahiro; Ishihara ...
ACS applied materials & interfaces/11(50)/pp.47428-47436, 2019-12 - Hydantoin and Its Derivatives Reduce the Viscosity of Concentrated Antibody Formulations by Inhibiting Associations via Hydrophobic Amino Acid Residues
Nishinami Suguru; Kameda Tomoshi; Arakawa Tsutomu; Shi...
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH/58(36)/pp.16296-16306, 2019-09 - more...
- Synthesis of Butterfly-like Shape Gold Nanomaterial: For the Regulation of Liquid–Liquid Phase-Separated Biomacromolecule Droplets
- Books
- 相分離生物学
白木 賢太郎
東京化学同人, 2019-08 - Terahertz Spectroscopic Study of Ion Effects on Protein Hydration
Hattori Toshiaki; Aoki Katsuyoshi; Shiraki Kentaro
2015 40TH INTERNATIONAL CONFERENCE ON INFRARED, MILLIMETER AND TERAHERTZ WAVES (IRMMW-THZ)/IEEE, 2015 - 生物科学入門
白木賢太郎
東京化学同人, 2009-12 - Synergistic effect of polyethylene glycol with arginine on the prevention of heat-induced aggregation of lysozyme - art. no. 012022
Tomita Shunsuke; Hamada Hiroyuki; Nagasaki Yukio; Shiraki...
SECOND INTERNATIONAL SYMPOSIUM ON ATOMIC TECHNOLOGY/IOP PUBLISHING LTD/pp.12022-12022, 2008-01
- 相分離生物学
- Conference, etc.
- Ultrafast Vibrational Energy Transfer from Photoexcited Carbon Nanotubes to Proteins
Nakayama Tomohito; Yoshizawa Shunsuke; Hirano Atsushi; ...
21st International Conference on Ultrafast Phenomena (UP)/2018-07-15--2018-07-20 - Fractal dimension, persistent homology dimension, and fractal dynamics in the terahertz region: the case of protein lysozyme
Mori Tatsuya; Fujii Yasuhiro; Kitani Suguru; Yamamoto Yo...
Materials Research Meeting 2019 (MRM 2019)/2019-12-10--2019-12-14 - Terahertz Spectroscopy on Myoglobin: Boson Peak and Fracton
Mori Tatsuya; Motoji Leona; Fujii Yasuhiro; Kitani Sugur...
IRMMW-THz 2019 (44th International Conference on Infrared, Millimeter and Terahertz Waves)/2019-09-01--2019-09-06 - Terahertz Spectroscopic Study on Protein Myoglobin: Polymer-Like Behavior of Vibrational Density of States
Motoji Leona; Mori Tatsuya; Fujii Yasuhiro; Koreeda Akit...
APS March Meeting 2019/2019-03-04--2019-03-08 - Terahertz time-domain spectroscopy of lyophilized protein lysozyme
Mori Tatsuya; Fujii Yasuhiro; Jiang Yue; Motoji Leona; Ki...
TGSW2018 (Tsukuba Global Science Week 2018)/2018-09-20--2018-09-22 - Detection of fractal dynamics of protein by terahertz spectroscopy
Mori Tatsuya; Fujii Yasuhiro; Jiang Yue; Motoji Leona; Te...
EUCMOS 2018 (XXXIV EUROPEAN CONGRESS ON MOLECULAR SPECTROSCOPY)/2018-08-19--2018-08-24 - Ultrafast Vibrational Energy Transfer from Photoexcited Carbon Nanotubes to Proteins
Nakayama Tomohito; Yoshizawa Shunsuke; Hirano Atsushi; Ta...
XXI International Conference on Ultrafast Phenomena 2018 (UP 2018)/2018-07-15--2018-07-20 - Terahertz Time-Domain Spectroscopy of Protein Myoglobin: Detection of Boson Peak and Fracton
Motoji Leona; Mori Tatsuya; Fujii Yasuhiro; Koreeda A...
43rd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)/2018-09-09--2018-09-14 - Detection of Boson Peak and Fractal Dynamics of Protein by Terahertz Time-Domain Spectroscopy
Mori Tatsuya; Jiang Yue; Fujii Yasuhiro; Kitani Sugur...
43rd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)/2018-09-09--2018-09-14 - Hydration of aqueous polymers investigated by terahertz spectroscopy and principal component analysis
Aoki Katsuyoshi; Hata Ryusuke; Kaneyasu Junya F.; Schwaab...
2018 43rd International Conference on Infrared, Millimeter and Terahertz Waves/2018-09-09--2018-09-14 - カーボンナノチューブ - 蛋白質複合体内の超高速振動エネルギー移動
中山 智仁; 吉澤俊祐; 平野 篤; 田中 丈士; 白木 賢太郎; 長谷 宗明
2018年第65回応用物理学会春季学術講演会/2018-03-17--2018-03-20 - テラヘルツ帯赤外・ラマン分光によるリゾチームのボゾンピークおよびフラクトンダイナミクス
姜 越; 森 龍也; 藤井 康裕; 是枝 聡肇; 山本 洋平; 白木 賢太郎; 小島 誠治
日本セラミックス協会 第30回秋季シンポジウム/2017-09-19--2017-09-21 - Boson peak and fractal dynamics study of protein keratin
Motoji Leona; Mori Tatsuya; Jiang Yue; Yoshizawa Shunsuk...
TGSW-IWP2017 (TGSW-Interdisciplinary Workshop on Science and Patents 2017)/2017-09-26--2017-09-26 - Boson peak and facton behavior of lysozyme
Jiang Yue; Mori Tatsuya; Fujii Yasuhiro; Motoji Leona; Yo...
TGSW-IWP2017 (TGSW-Interdisciplinary Workshop on Science and Patents 2017)/2017-09-26--2017-09-26 - A Study of Boson Peak and Fracton in Protein Lysozyme by Terahertz Time-domain Spectroscopy
Jiang Yue; Mori Tatsuya; Fujii Yasuhiro; Kitani Suguru; Y...
APS March Meeting 2018/2018-03-05--2018-03-09 - テラヘルツ時間領域分光によるタンパク質リゾチームのボゾンピークとフラクトンの検出
森 龍也; 姜 越; 藤井 康裕; 気谷 卓; 吉澤 俊祐; 泉二 玲緒奈; 白木 賢太郎; 山本 洋平; 是枝 ...
日本物理学会 第73回年次大会 (2018年)/2018-03-22--2018-03-25 - Synergistic effect of polyethylene glycol with arginine on the prevention of heat-induced aggregation of lysozyme - art. no. 012022
Tomita Shunsuke; Hamada Hiroyuki; Nagasaki Yukio; Shiraki...
2nd International Symposium on Atomic Technology
- Ultrafast Vibrational Energy Transfer from Photoexcited Carbon Nanotubes to Proteins
- Intellectural property rights
- 蛋白質を含む液状組成物中における蛋白質の安定化方法
Shiraki Kentaro - 水系溶媒中へのカーボンナノチューブの分散方法
Shiraki Kentaro
- 蛋白質を含む液状組成物中における蛋白質の安定化方法
- Teaching
2023-04 -- 2023-08 Open Seminar VB University of Tsukuba. 2023-04 -- 2023-08 Joint Seminar IIB University of Tsukuba. 2023-04 -- 2023-08 Joint Seminar IIA University of Tsukuba. 2023-10 -- 2024-02 Research in MI IIIA University of Tsukuba. 2024-01 -- 2024-02 Linear Algebra 3 University of Tsukuba. 2023-10 -- 2024-02 Joint Seminar IB University of Tsukuba. 2023-04 -- 2023-08 Research in MI VB University of Tsukuba. 2023-10 -- 2024-02 Research in IMI VB University of Tsukuba. 2023-10 -- 2024-02 Research in MI IIA University of Tsukuba. 2023-10 -- 2024-02 Research in Applied Physics IIIA University of Tsukuba. more... - Talks
- Protein Aggregation Technology
Shiraki Kentaro
企業現場のニーズと先端蛋白質科学との接点を探るシンポジウム/2016-11-16--2016-11-16
- Protein Aggregation Technology
(Last updated: 2023-08-02)