Chiba Shigeru
- Affiliation
- Faculty of Medicine
- Official title
- Professor
- URL
- 5>.34-,V?6DN]Y@849W90?
- Office
- 血液腫瘍学研究室
- Research fields
Hematology - Research projects
胚中心B細胞とリンパ球再循環に注目した濾胞性ヘルパーT細胞リンパ腫病態の解明 2019 -- 2021 千葉 滋 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B) 17,550,000Yen 血管免疫芽球性T細胞リンパ腫の病態解明と診断・治療法開発をめざす統合的アプローチ 2016 -- 2018 千葉 滋 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(A) 47,450,000Yen 骨髄赤芽球造血ニッチの解明 2015 -- 2016 千葉 滋 Japan Society for the Promotion of Science/Grant-in-Aid for challenging Exploratory Research 3,640,000Yen エイジングに伴うエピゲノム変化に注目した造血幹細胞の前がん化機構 2015 -- 2016 千葉 滋 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research on Innovative Areas 9,890,000Yen 悪性リンパ腫における腫瘍細胞と微小環境とのコミュニケーション 2013 -- 2014 千葉 滋 Japan Society for the Promotion of Science/新学術領域研究(研究領域提案型) 11,180,000Yen 悪性リンパ腫を構成する炎症細胞の起源の解明 2013 -- 2014 千葉 滋 Japan Society for the Promotion of Science/挑戦的萌芽研究 3,770,000Yen - Career history
2001-07 -- 2003-11 University of TokyoFaculty of MedicineLecturer 2003-11 -- 2008-03 University of TokyoFaculty of MedicineAssociate Professor 2008-03 -- (current) University of TsukubaFaculty of MedicineProfessor - Academic background
1978-04 -- 1984-03 University of Tsukuba School of Medicine 1987-04 -- 1991-03 The University of Tokyo Graduate School, Division of Medical Sciences - Degree
1991 医学博士 The University of Tokyo - Academic societies
1988 -- (current) The Japanese Cancer Association 1987 -- (current) THE JAPANESE SOCIETY OF HEMATOLOGY -- (current) Japan Society for Hematopoietic Cell Transplantation 1986 -- (current) THE JANPANESE SOCIETY OF INTERNAL MEDICINE -- (current) The Molecular Biology Society of Japan -- (current) JAPANESE SOCIETY FOR IMMUNOLOGY -- (current) Japanese Society of Medical Oncology (JSMO) 2003 -- (current) American Society of Hematology -- (current) International Society for Stem Cell Research - Articles
- [Lymphoplasmacytic lymphoma accompanied by severe myelofibrosis]
Takarada Ayako; Momose Haruka; Kurita Naoki; Matsuoka ...
[Rinsho ketsueki] The Japanese journal of clinical hematology/64(1)/pp.54-59, 2023-04-01 - [Hematopoietic recovery by ASXL1-mutated clones after immune suppressive therapy in a patient with severe aplastic anemia]
Shimizu Yumoe; Nishikii Hidekazu; Iitsuka Tadashi; Mat...
[Rinsho ketsueki] The Japanese journal of clinical hematology/64(1)/pp.49-53, 2023-04-01 - [Waldenström macroglobulinemia complicated by peripheral neuropathy due to neural infiltration]
Norioka Natsuki; Kurita Naoki; Kamura Yuya; Sakamoto ...
[Rinsho ketsueki] The Japanese journal of clinical hematology/64(1)/pp.18-22, 2023-04-01 - TMPRSS2 gene polymorphism common in East Asians confers decreased COVID-19 susceptibility
Sekiya Takeshi; Ogura Yukino; Kai Hirayasu; Kawaguchi ...
Frontiers in microbiology/13, 2022-04-01 - Prospective comparison of 5-and 7-day administration of azacitidine for myelodysplastic syndromes: a JALSG MDS212 trial
Miyazaki Yasushi; Kiguchi Toru; Sato Shinya; Usuki Ke...
INTERNATIONAL JOURNAL OF HEMATOLOGY/116(2:SI)/pp.228-238, 2022-05 - ETNK1 mutations defines a subclass of der(1;7)(q10;p10) in myelodysplastic syndromes
Okuda Rurika; Nannya Yasuhito; Ochi Yotaro; Chonabayas...
CANCER SCIENCE/113(1:SI)/pp.824-824, 2022-02 - Direct Reprogramming Improves Cardiac Function and Reverses Fibrosis in Chronic Myocardial Infarction
Taketaro Sadahiro; Hidenori Tani; Yu Yamada; Mari Isomi; ...
Circulation, 2022-12 - Triple-negative Thrombocythemia and Subsequent Acute Lymphoblastic Leukemia with Additional Somatic Mutations
Tsuboi Yuri; Sakamoto Tatsuhiro; Makishima Kenichi; Su...
Internal medicine (Tokyo, Japan), 2022-09-13 - Follow-up of Patients With FLT3-Mutated Relapsed or Refractory Acute Myeloid Leukaemia in the Phase 3 ADMIRAL Trial
Perl Alexander E.; Larson Richard A.; Podoltsev Nikola...
BRITISH JOURNAL OF HAEMATOLOGY/197(1:SI)/pp.6-7, 2022-04 - Administration of brentuximab vedotin to a Hodgkin lymphoma patient with liver dysfunction due to vanishing bile duct syndrome resulting in a partial response without any severe adverse events
Ishitsuka Kantaro; Yokoyama Yasuhisa; Baba Naoko; Mats...
JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY/62(3)/pp.154-157, 2022-07-12 - A Case of Cardiac Tamponade as a Recurrence of Angioimmunoblastic T-Cell Lymphoma with the Detection of a p.Gly17Val RHOA Mutation in the Pericardial Effusion
Tsuboi Yuri; Iimura Yumoe; Matsumura Fumiaki; Nanmoku To...
Internal medicine (Tokyo, Japan), 2022-06-21 - Long-term follow-up of patients with paroxysmal nocturnal hemoglobinuria treated with eculizumab: post-marketing surveillance in Japan
Ikezoe Takayuki; Noji Hideyoshi; Ueda Yasutaka; Kanda ...
INTERNATIONAL JOURNAL OF HEMATOLOGY/115(4)/pp.470-480, 2022-02-11 - [Acquired platelet dysfunction with severe bleeding tendency in triple-negative myelofibrosis]
Momose Haruka; Nishikii Hidekazu; Kozuma Yukinori; Ota-Ts...
[Rinsho ketsueki] The Japanese journal of clinical hematology/62(9)/pp.1406-1411, 2021-09 - Follow-up of patients with R/R FLT3-mutation-positive AML treated with gilteritinib in the phase 3 ADMIRAL trial.
Perl AE; Larson RA; Podoltsev NA; Strickland SA; Wang ES...
BLOOD/139(23)/pp.3366-3375, 2022-01 - Salvage Cord Blood Transplantation Using a Short-term Reduced-intensity Conditioning Regimen for Graft Failure.
Suma S; Yokoyama Y; Momose H; Makishima K; Kiyoki Y; Saka...
INTERNAL MEDICINE/61(11)/pp.1673-1679, 2021-11 - A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling
Abe Yoshiaki; Sakata-Yanagimoto Mamiko; Fujisawa Manab...
Nature cell biology/24(4)/pp.565-578, 2022-03 - [IgG-variant Bing-Neel syndrome diagnosed by detecting MYD88 L265P mutation in the cerebrospinal fluid cells]
Maruyama Yumiko; Nishikii Hidekazu; Matsuoka Ryota; Makis...
[Rinsho ketsueki] The Japanese journal of clinical hematology/62(10)/pp.1493-1498, 2021-10 - Mapping the human genetic architecture of COVID-19
Niemi Mari E. K.; Karjalainen Juha; Liao Rachel G.; Ne...
NATURE/600/pp.472-477, 2021-12 - A case of solitary plasmacytoma of bone showing co-expression of both immunoglobulin light chains
Matsuoka Ryota; Sakamoto Noriaki; Kato Takayasu; Chiba S...
European journal of medical research/26(1)/p.148, 2021-12 - Intratumor heterogeneity of lymphoma identified by multiregion sequencing of autopsy samples
Makishima Kenichi; Suehara Yasuhito; Abe Yoshiaki; Hattor...
CANCER SCIENCE/113(1)/pp.362-364, 2021-11 - Retrospective analyses of other iatrogenic immunodeficiency-associated lymphoproliferative disorders in patients with rheumatic diseases
Kaji Daisuke; Kusakabe Manabu; Sakata-Yanagimoto Mamiko; ...
BRITISH JOURNAL OF HAEMATOLOGY/195(4)/pp.585-594, 2021-09 - Tet2 deficiency in immune cells exacerbates tumor progression by increasing angiogenesis in a lung cancer model
Nguyen Yen T M; Fujisawa Manabu; Nguyen Tran B; Suehara ...
Cancer science/112(12)/pp.4931-4943, 2021-10 - Gilteritinib versus chemotherapy in Japanese patients with FLT3-mutated relapsed/refractory acute myeloid leukemia
Hosono Naoko; Yokoyama Hisayuki; Aotsuka Nobuyuki; And...
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY/26(11)/pp.2131-2141, 2021-08 - Rationale, Design, and Feasibility of a Prospective Multicenter Registry Study of Anthracycline-Induced Cardiotoxicity (AIC Registry)
Inoue Keiko; Iida Noriko; Tajiri Kazuko; Bando Hiroko...
JOURNAL OF CLINICAL MEDICINE/10(7), 2021-04 - VAV1 mutations contribute to development of T-cell neoplasms in mice
Fukumoto Kota; Sakata Mamiko; Fujisawa Manabu; Miyoshi H...
CANCER SCIENCE/112(1:SI)/pp.252-252, 2021-02 - more...
- [Lymphoplasmacytic lymphoma accompanied by severe myelofibrosis]
- Books
- マイクロRNAと骨髄異形成症候群
横山 泰久; 千葉 滋
血液内科/科学評論社/pp.747-753, 2014-06 - 成人の原発性慢性好中球減少症の臨床像
横山 泰久; 千葉 滋
血液内科/科学評論社/pp.543-547, 2016-10 - 慢性特発性好中球減少症におけるクローン性造血の頻度と予後
横山 泰久; 千葉 滋
血液内科/科学評論社/pp.212-215, 2022-08 - Ⅱ造血器腫瘍の基礎 3.造血器腫瘍の遺伝子変異 (1)クローン性造血と造血器腫瘍
末原泰人; 千葉 滋
造血器腫瘍学(第2版)-基礎と臨床の最新研究動向- 日本臨床 78巻増刊号3 /日本臨床社/pp.95-101, 2020-08 - 第7章 シーケンスデータの品質の指標と変異・CNVデータの読み方
末原泰人; 服部圭一朗; 千葉 滋
がんゲノム医療 結果報告書の読み方と患者への伝え方~エキスパートパネルの実際~/株式会社医学と看護社/pp.48-54, 2020-05 - 巻頭トピックス 7.血管免疫芽球性T細胞リンパ腫の分子標的治療
千葉 滋
血液疾患最新の治療2020-2022/南山堂/pp.35-39, 2019-10 - 第9章 変異の効果予測
日下部学; 坂東 裕子; 千葉 滋
がんゲノム医療 結果報告書の読み方と患者への伝え方~エキスパートパネルの実際~/株式会社医学と看護社/pp.59-65, 2020-05 - 第2編 第2章 第5節 血液がんの変異遺伝子を標的とした個別化治療への応用-血液がんにおけるPRECISION MEDICINE-
末原泰人; 日下部学; 坂田(柳元) 麻実子; 千葉 滋
プレシジョン・メディシン/エヌ・ティー・エス/pp.229-253, 2018-10 - NOTCH in Malignant Lymphoma
Chiba Shigeru
Notch Signaling Immunity and Cancer/Springer Nature/pp.79-92, 2017-09 - 16.血液・造血器の疾患 16-3 血球の動態と機能 2)白血球の動態と機能 (2)リンパ球の動態と機能
Chiba Shigeru
内科学 第11版 Ⅴ/朝倉書店/p.1872, 2017-03 - 第2章 C 造血幹細胞を制御する遺伝子 2 Notch遺伝子
加藤貴康; Chiba Shigeru
造血器腫瘍アトラス 改訂第5版/日本医事新報社/pp.45-51, 2016-08 - 2.造血幹細胞移植分野におけるES・iPS細胞を用いた再生医療の試み
錦井秀和; 横山泰久; Chiba Shigeru
みんなに役立つ造血幹細胞移植の基礎と臨床 改訂3版/医薬ジャーナル社/pp.35-42, 2016-06 - 7. ヒストンメチル化酵素DOT1Lの阻害薬によるMLL白血病の治療
千葉 滋; 加藤貴康
Annual Review血液2016/東京/pp.108-111, 2016-01 - 5章 B.白血病と類縁疾患 5.骨髄異形成症候群
千葉 滋
Principles and Practice 血液・造血器・リンパ系/東京/pp.254-262, 2015-10 - 3章 ヒト白血球抗原(HLA)
長谷川雄一; 千葉 滋
Principles and Practice 血液・造血器・リンパ系/東京/pp.112-118, 2015-10 - 1章 構造と機能 1.血液の構成成分
千葉 滋
Principles and Practice 血液・造血器・リンパ系/東京/pp.2-5, 2015-10 - Principles and Practice 血液・造血器・リンパ系
千葉 滋; 長谷川雄一
文光堂, 2015-10 - 第9章 Notchシグナル 概論
千葉 滋
サイトカイン・増殖因子キーワード辞典/羊土社/pp.349-351, 2015-04 - Notch遺伝子
千葉 滋
医学大辞典 第20版/南山堂/p.1910, 2015-04 - ヒト顆粒球・マクロファージコロニー刺激因子受容体の解析
千葉 滋
1991-05 - 骨髄微小環境でのNotch活性化と骨髄増殖性疾患
横山泰久; 千葉滋
HEMATLOGY & ONCOLOGY/科学評論社/pp.326-331, 2009-09 - 幹細胞を用いた血液再生
横山泰久; 小川誠司; 千葉滋
治療/治療/pp.2043-2048, 2010-08 - Chapter 14 Hematopoietic differentiation from Embryonic Stem Cells
Yokoyama Y; Nishikii H; Chiba S
Embryonic Stem Cells - Recent Advances in Pluripotent Stem Cell-Based Regenerative Medicine/InTech/pp.251-272, 2011-03 - 臨床検査ガイド2009-2010「血液腫瘍の遺伝子検査」
鈴川和己; 千葉滋(編集・和田攻; 大久保昭行; 矢崎義雄; 大内尉義); +千葉 滋
文光堂, 2009-02 - 造血器腫瘍アトラス(改訂第4版)「Notch遺伝子」
千葉滋(編集・阿部達生); +千葉 滋
日本医事新報社, 2009-04 - more...
- マイクロRNAと骨髄異形成症候群
- Conference, etc.
- タクロリムスとレテルモビルの併用中にボリコナゾールを追加した造血幹細胞移植患者の一例
森山 侑太; 加藤 貴康; 千葉 滋; 鈴木 嘉治; 本間 真人
日本薬学会第141年会/2021-3-26--2021-3-29 - 高度な骨髄線維化を認め診断に苦慮したリンパ形質細胞性リンパ腫の1例
宝田 亜矢子; 百瀬 春佳; 栗田 尚樹; 坂本 竜弘; 加藤 貴康; 服部 圭一朗; 末原 泰人; 横山 泰久...
第16回 日本血液学会関東甲信越地方会/2022-03-19--2022-03-19 - Birt-Hogg-Dube症候群に合併した多発性骨髄腫の1例
松村 文明; 坂本 竜弘; 甲斐 平康; 加藤 貴康; 栗田 尚樹; 横山 泰久; 錦井 秀和; 坂田(柳元) ...
第675回日本内科学会関東地方会/2022-02-12--2022-02-12 - シングルセル解析によるT 濾胞ヘルパー細胞リンパ腫の免疫プロファイルおよび腫瘍細胞不均一性の解明
須摩桜子; 藤澤 学; 安部 佳亮; 末原 泰人; 日下部 学; 梶 大介; 杉尾 健志; 加藤 光次; 赤司 浩...
第26回 造血器腫瘍研究会/2022-01-21--2022-01-22 - クローン造血由来胚中心B 細胞はT 細胞リンパ腫の腫瘍化に寄与する
藤澤 学; Tran B. Nguyen; 安部 佳亮; 末原 泰人; 須摩 桜子; 三浦 史仁; 伊藤 隆司; ...
第26回 造血器腫瘍研究会/2022-01-21--2022-01-22 - Molecular International Prognosis Scoring System for Myelodysplastic Syndromes
Bernard Elsa; Tuechler Heinz; Greenberg Peter L.; Hasserj...
63rd ASH Annual Meeting and Exposition/2021-12-11--2021-12-14 - Clinical Significance of Small PNH-Type Cell Populations in Bone Marrow Failure Syndromes - an Interim Analysis of Japanese Multicentrer Prospective Study -
Ueda Yasutaka; Hosokawa Kohei; Ishiyama Ken; Takamori Hi...
63rd ASH Annual Meeting and Exposition/2021-12-11--2021-12-14 - EPOR/JAK/STAT Signaling Pathway As Therapeutic Target of Acute Erythroid Leukemia
Takeda June; Yoshida Kenichi; Nakagawa Masahiro Marshall...
63rd ASH Annual Meeting and Exposition/2021-12-11--2021-12-14 - Der(1;7)(q10;p10) Presents with a Unique Genetic Profile and Frequent ETNK1 Mutations in Myeloid Neoplasms
Okuda Rurika; Nannya Yasuhito; Ochi Yotaro; Creignou Mar...
63rd ASH Annual Meeting and Exposition/2021-12-11--2021-12-14 - S100a8/S100a9-Emmprin-Vegfa Axis Initiated By Tet2-Deficient Immune Cells Exacerbates Lung Cancer Progression through Promotion of Angiogenesis
Nguyen Yen T.M.; Fujisawa Manabu; Nguyen Tran B.; Suehara...
63rd ASH Annual Meeting and Exposition/2021-12-11--2021-12-14 - A Single-Cell Atlas of Nonhematopoietic Cells in Human Lymph Node and Lymphoma Reveals Landscape of Stromal Remodeling
Abe Yoshiaki; Sakata-Yanagimoto Mamiko; Fujisawa Manabu; ...
63rd ASH Annual Meeting and Exposition/2021-12-11--2021-12-14 - Germinal Center B Cells Derived from TET2-Mutated Clonal Hematopoiesis Provide a Microenviromental Niche for Tumor Cells in Angioimmunoblastic T-Cell Lymphoma
Fujisawa Manabu; Nguyen Tran B.; Abe Yoshiaki; Suehara Y...
63rd ASH Annual Meeting and Exposition/2021-12-11--2021-12-14 - ETNK1 mutations defines a subclass of der(1;7)(q10;p10) in myelodysplastic syndromes
Okuda Rurika; Nannya Yasuhito; Ochi Yotaro; Chonabayashi ...
第80回日本癌学会学術総会/2021-09-30--2021-10-02 - 赤白血病におけるゲノム解析と治療標的の検討
竹田 淳恵; 吉田 健一; 依田 成玄; 南谷 泰仁; 越智 陽太郎; 中川 正宏; 佐伯 龍之介; 白石 友一...
第80回日本癌学会学術総会/2021-09-30--2021-10-02 - Single-cell RNA sequencing reveals immune profile and tumor cell heterogeneity of angioimmunoblastic T-cell lymphoma
Suma Sakurako; Fujisawa Manabu; Abe Yoshiaki; Suehara Ya...
第80回日本癌学会学術総会/2021-09-30--2021-10-02 - Identification of the intra-tumor heterogeneity of lymphoma by multi-region sequencing
槇島健一; 末原泰人; 日下部学; 千葉 滋; 坂田(柳元)麻実子
第80回日本癌学会学術総会/2021-09-30--2021-10-02 - Tet2-deficient immune cells serve as niches to promote cancer progression: T-cell lymphoma and lung cancer models
Sakata-yanagimoto Mamiko; Fujisawa Manabu; Yen Nguyen; Ch...
第80回日本癌学会学術総会/2021-09-30--2021-10-02 - TET2-mutated germinal center B-cells drive tumorigeneis through CD40-CD40LG axis in angioimmunoblastic T-cell lymphoma
Fujisawa Manabu; Nguyen Tran; Abe Yoshiaki; Suehara Yasu...
第80回日本癌学会学術総会/2021-09-30--2021-10-02 - Tet2-deficent inflammatory cells exacerbates lung cancer progression through promoting tumor angiogenesis
Nguyentm Yen; Fujisawa Manabu; Nguyen Tran B.; Suehara Y...
第80回日本癌学会学術総会/2021-09-30--2021-10-02 - A Comprehensive Single-Cell Atlas of Nonhematopoietic Cells in Lymphoma Reveals Landscape of Stromal Remodeling
Abe Yoshiaki; Sakata-Yanagimoto Mamiko; Fujisawa Manabu; ...
第80回日本癌学会学術総会/2021-09-30--2021-10-02 - Follow-up of patients with FLT3-mutated relapsed or refractory AML in the Phase 3 ADMIRAL trial
Onozawa Masahiro; Perl Alexander E.; Larson Richard A.; P...
第83回日本血液学会学術集会/2021-09-23--2021-09-25 - EPOR/JAK/STAT pathway is a promising therapeutic target in acute erythroid leukemia
Takeda June; Yoshida Kenichi; Yoda Akinori; Nannya Yasuh...
第83回日本血液学会学術集会/2021-09-23--2021-09-25 - ETNK1 mutations defines a subclass of der(1;7)(q10;p10) in myelodysplastic syndromes
Okuda Rurika; Nannya Yasuhito; Ochi Yotaro; Chonabayashi ...
第83回日本血液学会学術集会/2021-09-23--2021-09-25 - Post-azacitidine clone size predicts long-term clinical outcome of patients with MDS and AML
Nannya Yasuhito; Magnus Tobiasson; Sato Shinya; Elsa Ber...
第83回日本血液学会学術集会/2021-09-23--2021-09-25 - Real-world experience of Ph(-)ALL treated with a pediatric regimen: a single center study
Yuki Yoshizawa; Takayasu Kato; Kenichi Makishima; Yufu I...
第83回日本血液学会学術集会/2021-09-23--2021-09-25 - more...
- タクロリムスとレテルモビルの併用中にボリコナゾールを追加した造血幹細胞移植患者の一例
- Teaching
2022-04 -- 2022-08 Advanced Exercise on Public Health University of Tsukuba. 2022-10 -- 2023-02 Advanced Exercise on Public Health University of Tsukuba. 2022-04 -- 2022-08 Diagnostic Pathology in Practice II University of Tsukuba. 2022-10 -- 2023-02 Diagnostic Pathology in Practice II University of Tsukuba. 2022-10 -- 2023-02 Lectures in Pathology and Forensic Medicine University of Tsukuba. 2022-04 -- 2022-08 Lectures in Pathology and Forensic Medicine University of Tsukuba. 2022-04 -- 2022-08 International Practical Medical Sciences University of Tsukuba. 2022-10 -- 2023-02 International Practical Medical Sciences University of Tsukuba. 2022-10 -- 2023-02 Practice in Diagnostic Pathology II University of Tsukuba. 2022-04 -- 2022-08 Practice in Diagnostic Pathology II University of Tsukuba. more... - Talks
- Hematopoiesis and blood cancers
千葉 滋
第83回日本血液学会学術集会/2021-09-23--2021-09-25
- Hematopoiesis and blood cancers
- Professional activities
2008 -- (current) The Japanese Cancer Association councilor 1999 -- (current) THE JAPANESE SOCIETY OF HEMATOLOGY 評議員 2009 -- (current) Japan Society for Hematopoietic Cell Transplantation 評議員
(Last updated: 2023-01-16)