Saito Tsuyoshi
- Affiliation
- University of Tsukuba
- Official title
- Assistant Professor
- ORCID
- 0000-0001-6105-6292
- Office
- Saito Lab (Kutsumura/Saito Lab)
- Research fields
Green/Environmental chemistry Drug development chemistry Bio-related chemistry - Research keywords
Medicinal Chemistry, Chemical Biology, Electron Transfer, Bioluminescence - Research projects
安全なサリドマイド誘導体による新たな不眠症治療 2022-04 -- 2023-03 斉藤毅 Univ. of Tsukuba/令和4年度AMED 「橋渡し研究プログラム」筑波大学拠点/シーズ A研究 マルチスケールな生理作用の因数分解基盤構築の支援 2021-08 -- 2024-03 日本学術振興会/学術変革領域研究(B) 5,460,000Yen モルヒナン骨格を基盤とした三次元的フォーカスドライブラリーの構築 2021-08 -- 2024-03 斉藤毅 JSPS/学術変革領域研究(B) 30,030,000Yen オレキシン1受容体選択的作動薬の創出と薬理作用の解明 2020-04 -- 2023-03 長瀬博(分担:斉藤毅) 日本学術振興会/科学研究費 基盤研究(B) 1,080,000Yen オレキシン1受容体を標的としたPETプローブの開発 2020-04 -- 2023-03 斉藤毅 日本学術振興会/科学研究費 基盤研究(C) 4,420,000Yen バイアスリガンド開発に資するG蛋白質/アレスチン-GPCR複合体の構造解析 2019-04 -- 2023-03 寿野良二(分担:斉藤毅) 日本学術振興会/科学研究費 基盤研究(B) 1,500,000Yen 睡眠覚醒を制御するオレキシン受容体の構造解析と機能解明 2018-04 -- 2019-03 斉藤毅 筑波大学/TARAプロジェクト(公募型) 500,000Yen オレキシン2型受容体作動薬による代謝リズム調節機構の解明 2018-04 -- 2021-03 福住昌司(分担:斉藤毅) 日本学術振興会/科学研究費 基盤研究(C) 500,000Yen 動機づけ行動による徐波睡眠制御における側坐核の役割 2017-04 -- 2020-03 ラザルス ミハエル(分担:斉藤毅) 日本学術振興会/科学研究費 基盤研究(B) 900,000Yen 光により覚醒を制御する分子ツールの開発 2018-04 -- 2020-03 斉藤毅 日本学術振興会/科学研究費若手 4,160,000Yen more... - Career history
2013-04 -- (current) University of TsukubaInternational Institute for Integrative Sleep MedicineAssistant Professor 2012-06 -- 2012-10 Johanes Gutenberg-University MainzInstitute of Organic ChemistryVisiting Researcher 2011-04 -- 2013-03 Keio UniversityFaculty of Science and Technology, Department of ChemistryResearch Associate - Academic background
2009-04 -- 2012-03 Keio University School of Fundamental Science and Technology 2007-04 -- 2009-03 Keio University School of Fundamental Science and Technology 2003-04 -- 2007-03 Keio University Faculty of Science and Technology Department of Chemistry - Degree
2012-03 Ph.D. of Science Keio University - Academic societies
2019-06 -- (current) FLOWST 2014-04 -- (current) 電気化学会有機電子移動化学研究会 2014-04 -- (current) The Pharmaceutical Society of Japan, Division of Medicinal Chemistry 2014-04 -- (current) THE PHARMACEUTICAL SOCIETY OF JAPAN 2010-06 -- (current) THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY 2007-04 -- 2014-03 The Japanese Association for the Pursuit of New Bioactive Resources 2008-05 -- (current) JAPANESE SOCIETY FOR CHEMICAL BIOLOGY 2006-01 -- (current) THE CHEMICAL SOCIETY OF JAPAN - Honors & Awards
2022 TRiSTAR (Top Runners in Strategy of Transborder Advanced Researches) Pre Fellow 2019 Reaction Chemistry & Engineering poster prize at SelectBIO Flow Chemistry Asia 2019 Natural Product Synthesis with Electrochemical Flow Reactions 2017 若手研究奨励賞 2016 優秀講演賞 Development of non-peptidic orexin receptor agonists for controlling sleep/wake cycle 2015 メディシナルケミストリーシンポジウム優秀賞 低分子オレキシン受容体アゴニストの創製 2014 倉田奨励金 安定かつ多色発光するホタルルシフェリンアナログの開発 2013 有機電気化学奨励賞 有機電解反応を活用した天然物合成 2011 慶應藤原賞 2010 日本ケミカルバイオロジー学会第5回年会「ポスター賞」 2009 新規素材探索研究会第8回セミナー「最優秀ポスター賞」 2008 小泉信三記念奨学金 - Articles
- Novel Baeyer–Villiger-type oxidation of 4,5-epoxymorphinan derivatives
Hino Tsubasa; Kutsumura Noriki; Saitoh Tsuyoshi; Yamamoto...
Tetrahedron Letters/63(19)/pp.152714-152714, 2021-01 - Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library
斉藤 毅
European Journal of Medicinal Chemistry/p.114505, 2022-06 - Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands
Iio Keita; Kutsumura Noriki; Nagumo Yasuyuki; Saitoh ...
Bioorganic & Medicinal Chemistry Letters/56(15)/pp.128485-128485, 2022-01 - Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton
Hino Tsubasa; Saitoh Tsuyoshi; Nagumo Yasuyuki; Yamamo...
Bioorganic & Medicinal Chemistry Letters/59(1)/pp.128530-128530, 2022-03 - Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives
Katoh Koki; Kutsumura Noriki; Yamamoto Naoshi; Nagumo ...
Bioorganic & Medicinal Chemistry Letters/59(1)/pp.128550-128550, 2022-03 - Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors
Katoh Koki; Yamamoto Naoshi; Ishikawa Yukiko; Irukayam...
Bioorganic & medicinal chemistry letters/59(1)/pp.128527-128527, 2022-03 - Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring
Iio Keita; Saitoh Tsuyoshi; Ohshita Ryuichiro; Hino Tsub...
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS/60(15)/pp.128555-128555, 2022-03 - Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation
Shokirova Hurramhon; Inomata Takenori; Saitoh Tsuyoshi...
SCIENTIFIC REPORTS/11(1), 2021-04 - Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors
Tsai Chia-Jung; Nagata Takeshi; Liu Chih-Yao; Suganuma...
Cell reports/36(7), 2021-08 - Anodic Oxidation of Phenols: A Key Step for the Synthesis of Natural Products
Yamamoto Takashi; Saitoh Tsuyoshi; Einaga Yasuaki; Nis...
CHEMICAL RECORD/Epub, 2021-03 - Novel Baeyer-Villiger-type oxidation of 4,5-epoxymorphinan derivatives
Hino Tsubasa; Kutsumura Noriki; Saitoh Tsuyoshi; Yamam...
TETRAHEDRON LETTERS/63, 2021-01 - Orexin agonist improves inflammation-induced immobility
Uchida Shuntaro; Sakurai Takeshi; Irukayama Yoko T; Og...
Proceedings for Annual Meeting of The Japanese Pharmacological Society/2018/pp.OR23-1, 2018 - In vitro and in vivo pharmacology of YNT-X, a novel small-molecule orexin type 2 receptor agonist
滑川 由紀子; 入鹿山 容子; 小川 靖裕; 石川 由紀子; 山口 拓土; アキンデレ チト; 斉藤 毅; 長瀬 ...
Proceedings for Annual Meeting of The Japanese Pharmacological Society/92/pp.1-SS-65, 2019 - Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine
Nagumo Yasuyuki; Katoh Koki; Iio Keita; Saitoh Tsuyoshi; ...
Bioorganic & Medicinal Chemistry Letters/30(17), 2020-09 - Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities
Kutsumura N.; Koyama Y.; Saitoh T.; Yamamoto N.; Nagumo ...
Molecules/25(5)/pp.1112-1112, 2020-03 - Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group
Saito Tsuyoshi; Seki Kazunori; Nakajima Ryo; Yamamoto Na...
Bioorg. Med. Chem. Lett./30(3), 2019-12 - Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity
Saitoh Tsuyoshi; Seki Kazunori; Nakajima Ryo; Yamamoto N...
Bioorganic & medicinal chemistry letters/29(18)/pp.2655-2658, 2019-09 - Oxidative Cleavage of the Acyl-Carbon Bond in Phenylacetone with Electrogenerated Superoxide Anions
Zhang Yan; Sugai Tomoya; Yamamoto Takashi; Yamamoto Naos...
CHEMELECTROCHEM/6(16:::SI)/pp.4194-4198, 2019-08 - Electrochemical Pinacol Coupling of Acetophenone Using Boron-Doped Diamond Electrode
Nakahara Kenshin; Naba Keisuke; Saitoh Tsuyoshi; Sugai T...
CHEMELECTROCHEM/6(16:::SI)/pp.4153-4157, 2019-08 - A NOVEL REARRANGEMENT REACTION OF MORPHINAN TO ARYLMORPHAN SKELETONS AND THE PHARMACOLOGIES OF ARYLMORPHAN DERIVATIVES
Yata Masahiro; Kutsumura Noriki; Nagumo Yasuyuki; Yamamot...
HETEROCYCLES/99(1)/pp.134-144, 2019-04 - Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring
Yamamoto Naoshi; Ohrui Sayaka; Okada Takahiro; Saitoh Ts...
Bioorganic & medicinal chemistry/27(8)/pp.1747-1758, 2019-04 - Electrochemical Tryptophan-Selective Bioconjugation
Toyama Eisho; Maruyama Katsuya; Sugai Tomoya; Kondo Mio; ...
<i>ChemRxiv<i/>, 2019-03 - Enhancing endogenous adenosine A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function
Korkutata Mustafa; Saitoh Tsuyoshi; Cherasse Yoan; Ioka ...
Neuropharmacology/144/pp.122-132, 2018-10 - SYNTHESIS OF NOVEL 1,3-DIOXA-5-THIAZATRIQUINANE AND 1-OXA-3,5-DITHIAZATRIQUINANE DERIVATIVES AND THEIR PHARMACOLOGIES
Ohshita Ryuichiro; Kutsumura Noriki; Nagumo Yasuyuki; Yam...
HETEROCYCLES/97(2)/pp.687-695, 2018-09 - Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors
Wang Yibing; Cao Liqin; Lee Chia-Ying; Matsuo Tomohiko; W...
Nature communications/9(1)/p.2041, 2018-05 - more...
- Novel Baeyer–Villiger-type oxidation of 4,5-epoxymorphinan derivatives
- Books
- 睡眠覚醒を制御する化学物質
斉藤 毅; 長瀬 博
天然物の化学 II/東京化学同人/pp.29-36, 2018-07
- 睡眠覚醒を制御する化学物質
- Conference, etc.
- 1,3,5-Trioxazatriquinane骨格を用いたオレキシン受容体拮抗薬の開発
雨澤真櫻; 斉藤毅; 堀内惇平; 大下隆一郎; 山本直司; 南雲康行; 沓村 憲樹; 石川有紀子; 入鹿山容子; 長谷川恵美; 小川...
日本ケミカルバイオロジー学会 第15回年会/2021-06-21--2021-06-23 - δオピオイド受容体作動薬のストレス誘発うつ様症状の治療効果とその副作用発現機序の解明
徳田明久; 南雲康行; 片山; 上田壮志; 上園保仁; 山本直司; 斉藤毅; 沓村 憲樹; 長瀬博
第40回鎮痛薬・オピオイドペプチドシンポジウム/2021-09-04--2021-09-05 - 17-N-フルオロアルキルナルフラフィン誘導体の合成と薬理評価
坂本奈津美; 斉藤毅; 石川有紀子; 徳田明久; 日野翼; 山本直司; 南雲康行; 沓村 憲樹; 柳沢正史; 長瀬博
第65回日本薬学会関東支部大会/2021-09-11--2021-09-11 - Allosteric modulation of adenosine A2A receptors in mice induces slow-wave sleep without cardiovascular effects.
Korkutata Mustafa; Saitoh Tsuyoshi; Feng Duo; Murakoshi ...
World Sleep 2017/2017-10-07--2017-10-11
- 1,3,5-Trioxazatriquinane骨格を用いたオレキシン受容体拮抗薬の開発
- Teaching
2022-10 -- 2023-02 Practice in Medical Science of Sleep II University of Tsukuba. 2022-04 -- 2022-08 Lecture and Discussion in Medical Science of Sleep I University of Tsukuba. 2022-10 -- 2023-02 Seminar in Medical Science of Sleep II University of Tsukuba. 2022-04 -- 2022-08 Practice in Medical Science of Sleep I University of Tsukuba. 2022-04 -- 2022-08 Seminar in Medical Science of Sleep I University of Tsukuba. 2022-10 -- 2023-02 Lecture and Discussion in Medical Science of Sleep II University of Tsukuba. 2022-10 -- 2023-02 Practice in Medical Sciences of Sleep II University of Tsukuba. 2022-10 -- 2023-02 Seminar in Medical Sciences of Sleep II University of Tsukuba. 2022-10 -- 2023-02 Lecture and Discussion in Medical Sciences of Sleep II University of Tsukuba. 2022-04 -- 2022-08 Practice in Medical Sciences of Sleep I University of Tsukuba. more... - Message
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千葉大学 非常勤講師
(Last updated: 2022-12-20)