柴 綾(シバ アヤ)
- 所属
- 医学医療系
- 職名
- 准教授
- 性別
- 女性
- 科研費番号
- 50708427
- 研究分野
人体病理学 実験病理学 - 研究課題
チロシンキナーゼ分解を抑制し肺腺癌悪性化を招くSFNを標的とした治療戦略 2017 -- 2018 柴 綾 日本学術振興会/若手研究(B) 4,160,000円 結合蛋白に着目したStratifinによる肺腺癌初期悪性化の分子メカニズム解明 2014 -- 2015 柴 綾 日本学術振興会/若手研究(B) 3,900,000円 結合蛋白に着目したStratifinによる肺腺癌初期悪性化の分子メカニズム解明 2014-04 -- 2016-03 柴 綾 日本学術振興会/科学研究費/若手研究（B） 3,000,000円 Stratifin過剰発現によって引き起こされる肺腺癌の初期悪性化のメカニズム解析 2013-09 -- 2014-09 柴 綾 公益財団法人金原一郎記念医学医療振興財団/第28回基礎医学医療研究助成金 400,000円 - 取得学位
2012-03 博士（医学） 筑波大学 - 所属学協会
2013 -- (現在) 日本分子生物学会 2007 -- (現在) 日本病理学会 2006 -- (現在) 日本癌学会 - 受賞
2019-11 日本病理学会学術奨励賞 - 論文
- Novel therapeutic strategies targeting bypass pathways and mitochondrial dysfunction to combat resistance to RET inhibitors in NSCLC
Shiba-Ishii Aya; Isagawa Takayuki; Shiozawa Toshihiro; ...
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE/1870(6), 2024-08 - Histologic transformation of non-small-cell lung cancer in response to tyrosine kinase inhibitors: Current knowledge of genetic changes and molecular mechanisms
Shiba-Ishii Aya; Takemura Noriko; Kawai Hitomi; Matsub...
CANCER SCIENCE/115(7), 2024-05-27 - Expression patterns of HNF4α, TTF-1, and SMARCA4 in lung adenocarcinomas: impacts on clinicopathological and genetic features
Kawai Hitomi; Miura Tamaki; Kawamatsu Natsumi; Nakagaw...
Virchows Archiv : an international journal of pathology/Epub, 2024-05-06 - Gene expression profiles of the original tumors influence the generation of PDX models of lung squamous cell carcinoma
Kim Yunjung; Shiba-Ishii Aya; Nakagawa Tomoki; Takeuchi ...
LABORATORY INVESTIGATION/Epub, 2021-01 - Gene expression profiles of the original tumors influence the generation of PDX models of lung squamous cell carcinoma
Kim Yunjung; Shiba-Ishii Aya; Nakagawa Tomoki; Takeuchi ...
LABORATORY INVESTIGATION/Epub, 2021-01 - Analysis of lorlatinib analogs reveals a roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancer
Shiba-Ishii Aya; Johnson Ted W; Dagogo-Jack Ibiayi; Mi...
Nature cancer/3(6)/pp.710-722, 2022-06-01 - Mutational landscape of primary breast angiosarcoma with repeated resection and recurrence over a 15-year period: A case report
Teruyama Fumiya; Kuno Akihiro; Murata Yoshihiko; Nakag...
PATHOLOGY INTERNATIONAL/72(9)/pp.457-463, 2022-07-08 - Ovarian carcinoma immunoreactive antigen domain 2 controls mitochondrial apoptosis in lung adenocarcinoma
Hong Jeongmin; Shiba-Ishii Aya; Kim Yunjung; Noguchi Mas...
Cancer science/Epub, 2021-10 - Significance of stratifin in early progression of lung adenocarcinoma and its potential therapeutic relevance
Shiba-Ishii Aya
PATHOLOGY INTERNATIONAL/71(10)/pp.655-665, 2021-10 - Gene expression profiles of the original tumors influence the generation of PDX models of lung squamous cell carcinoma
Kim Yunjung; Shiba-Ishii Aya; Nakagawa Tomoki; Takeuchi ...
LABORATORY INVESTIGATION/Epub, 2021-01 - Heterotopic production of ceruloplasmin by lung adenocarcinoma is significantly correlated with prognosis
Matsuoka Ryota; Shiba-Ishii Aya; Nakano Noriyuki; Togayac...
Lung cancer (Amsterdam, Netherlands), 2018 - Heterotopic production of ceruloplasmin by lung adenocarcinoma is significantly correlated with prognosis
Matsuoka Ryota; Shiba-Ishii Aya; Nakano Noriyuki; Togayac...
Lung cancer (Amsterdam, Netherlands), 2018 - Heterotopic production of ceruloplasmin by lung adenocarcinoma is significantly correlated with prognosis
Matsuoka Ryota; Shiba-Ishii Aya; Nakano Noriyuki; Togayac...
Lung cancer (Amsterdam, Netherlands), 2018 - Cyclophilin A expression and its prognostic significance in lung adenocarcinoma
Nakano Noriyuki; Sakashita Shingo; Matsuoka Ryota; Murata...
Pathology international, 2017-10 - Cyclophilin A expression and its prognostic significance in lung adenocarcinoma
Nakano Noriyuki; Sakashita Shingo; Matsuoka Ryota; Murata...
Pathology international, 2018 - Cyclophilin A expression and its prognostic significance in lung adenocarcinoma
Nakano Noriyuki; Sakashita Shingo; Matsuoka Ryota; Murata...
Pathology international, 2018 - Cyclophilin A expression and its prognostic significance in lung adenocarcinoma
Nakano Noriyuki; Sakashita Shingo; Matsuoka Ryota; Murata...
Pathology international, 2018 - Cyclophilin A expression and its prognostic significance in lung adenocarcinoma
Nakano Noriyuki; Sakashita Shingo; Matsuoka Ryota; Murata...
Pathology international, 2018 - Cyclophilin A expression and its prognostic significance in lung adenocarcinoma
Nakano Noriyuki; Sakashita Shingo; Matsuoka Ryota; Murata...
Pathology international, 2018 - Carcinogen-induced tumors in SFN-transgenic mice harbor a characteristic mutation spectrum of human lung adenocarcinoma
Kim Yunjung; Shiba-Ishii Aya; Ramirez Karina; Muratani M...
Cancer science/110(8)/pp.2431-2441, 2019-05-29 - DNA hypomethylation-related overexpression of SFN, GORASP2 and ZYG11A is a novel prognostic biomarker for early stage lung adenocarcinoma
Husni Ryan Edbert; Shiba-Ishii Aya; Nakagawa Tomoki; Dai ...
Oncotarget/10(17)/pp.1625-1636, 2019-02 - Stratifin inhibits SCFFBW7 formation and blocks ubiquitination of oncoproteins during the course of lung adenocarcinogenesis
Shiba-Ishii Aya; Hong Jeongmin; Hirokawa Takatsugu; Kim ...
Clinical cancer research : an official journal of the American Association for Cancer Research/25(9)/pp.2809-2820, 2019-02-06 - The Novel SFN Inhibitors Aprepitant and Ticagrelor Exert Anti-Tumor Effects Through Blocking of Oncoprotein Ubiquitination
Shiba A.; Hong J.; Hirokawa T.; Kim Y.; Noguchil M.
JOURNAL OF THORACIC ONCOLOGY/13(10::S)/pp.S519-S519, 2018-10 - Heterotopic Expression of Ceruloplasmin in Lung Adenocarcinoma and its Possible Clinical Use as a Tumor Biomarker
Matsuoka R.; Shiba A.; Sakashita S.; Minami Y.; Noguchi M.
JOURNAL OF THORACIC ONCOLOGY/13(10::S)/pp.S561-S561, 2018-10 - High expression of ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) is associated with poor prognosis in lung adenocarcinoma
Sakashita Mai; Sakashita Shingo; Murata Yoshihiko; Shiba-...
Pathology international/68(11)/pp.596-604, 2018-10 - さらに表示...
- Novel therapeutic strategies targeting bypass pathways and mitochondrial dysfunction to combat resistance to RET inhibitors in NSCLC
- 著書
- 癌・腫瘍学 肺腺癌の初期からstratifinは腫瘍性タンパク質のユビキチン化による分解を抑制し、悪性化に関与する
野口 雅之; 柴 綾
医学のあゆみ Vol.277 No.12/医歯薬出版/pp.633-633, 2021-06 - マイクロダイセクション法
柴 綾; 里見 介史; 野口 雅之
病理と臨床, 2011-04
- 癌・腫瘍学 肺腺癌の初期からstratifinは腫瘍性タンパク質のユビキチン化による分解を抑制し、悪性化に関与する
- 会議発表等
- スフェロイド、オルガノイド、ゼノクラフトを用いた肺癌研究
柴 綾; Yungjun Kim; 中川 智貴; 竹内 朋代; 河合 瞳; 松岡 亮太; 坂本 規彰; 野口 雅之
第62回日本肺癌学会学術集会/2021-11-28--2021-11-28 - 浸潤部にのみFGFR T790M遺伝子変異が認められた、L858R遺伝子変異肺腺癌の1例
坂下信悟; 柴 綾; 関本 隆太郎; 村田 佳彦; 南 優子; 野口 雅之; 佐藤 幸夫
第58回日本肺癌学会学術集会/2018-11-29--2018-12-01 - miR-3941 targets IGBP1 and is associated with malignant progression of lung adenocarcinoma
佐藤 泰樹; 柴 綾; 坂下 信悟; 野口 雅之; 加野 准子
日本病理学会総会/2017-4-28 - Stratifin overexpression in lung adenocarcinoma blocks SCF ubiquitin ligase and accelerates tumor growth
柴 綾; 井口 由香里; 森下 由紀雄; 塩澤 利博; 猪山 慎二; 加野 准子; 野口 雅之
第36回日本分子生物学会年会/2013-12-03--2013-12-06 - Stratifin expressed in early invasive lung adenocarcinoma functionally enhances tumor progression and down-regulates SCFFbw7 ubiquitin ligase activity
Shiba Aya; Iguchi Yukari; Morishita Yukio; Shiozawa Toshihir...
World Conference on Lung Cancer/2013-10-27--2013-10-31
- スフェロイド、オルガノイド、ゼノクラフトを用いた肺癌研究
- 知的財産権
- 抗がん剤
広川 貴次; 野口 雅之; 柴 綾 - 抗がん剤
広川 貴次; 野口 雅之; 柴 綾
- 抗がん剤
- 担当授業科目
2024-10 -- 2025-02 病理診断学実習I 筑波大学 2024-04 -- 2024-08 病理診断学実習I 筑波大学 2024-04 -- 2024-07 人体病理学概論 筑波大学 2024-10 -- 2024-12 ゲノム医学概論 筑波大学 2024-10 -- 2025-02 病理診断学実習II 筑波大学 2024-04 -- 2024-08 病理診断学実習II 筑波大学 2024-05 -- 2024-08 医療・生命科学とテクノロジー 筑波大学 2024-05 -- 2024-05 病理組織学実習 筑波大学 2024-04 -- 2024-08 医科学セミナーV(キャリアパス) 筑波大学 2024-10 -- 2025-02 医科学セミナーV(キャリアパス) 筑波大学 さらに表示...
(最終更新日: 2023-08-03)