OBAYASHI Norihiko
- Affiliation
- Institute of Medicine
- Official title
- Associate Professor
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- Research fields
General physiology Cell biology - Research keywords
Small GTPases Membrane traffic Knockout mice Melanocyte - Research projects
色素細胞におけるRabとArfの協調 2022-04 -- 2025-03 Ohbayashi, Norihiko 日本学術振興会/科学研究費助成事業(基盤C) 4,160,000Yen メラニン合成酵素輸送を調節する Rab32/38 の新規制御機構の解明 2020-04 -- 2021-03 Norihiko Ohbayashi University of Tsukuba/花王メラニン研究会/令和2年度研究助成金 1,000,000Yen 色素細胞における低分子量Gタンパク質Arf6の機能解明 2019 -- 2021 大林 典彦 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C) 4,290,000Yen 間質性肺炎発症における低分子量Gタンパク質Arf6の機能解明 2018 -- 2018 大林典彦 武田科学振興財団/医学系研究奨励/ 2,000,000Yen メラニン合成酵素を輸送するRab32およびRab38の不活性化因子GAPの色素細胞における機能解析 2016-04 -- 2018-03 大林 典彦 公益財団法人コスメトロジー研究振興財団/第26回(平成27年度)研究助成金 1,000,000Yen Rabによるエフェクター分子分解機構の解明 Research Project 2015-04 -- 2018-03 大林 典彦 日本学術振興会/Grant-in-Aid for Scientific Research(C) 5,200,000Yen Rab40Cによるメラニン合成酵素の新規輸送制御機構の解明 2015-04 -- 2016-03 大林 典彦 花王メラニン研究会/平成27年度研究助成金 2,000,000Yen 色素細胞活性化におけるVarpの機能解析 研究課題 2012-04 -- 2015-03 大林 典彦 Japan Society of for the Promotion of Science/Grant-in-Aid for Scientific Research(C) 5,590,000Yen 新規Rab32/38結合分子によるメラノソーム形成・成熟機構の解明 研究課題 2010-04 -- 2012-03 大林 典彦 Japan Society of for the Promotion of Science/Grant-in-Aid for Scientific Research 4,290,000Yen 破骨細胞形成におけるFGFシグナルとサイトカインシグナルのクロストーク 2006-04 -- 2008-03 大林 典彦 Japan Society of for the Promotion of Science/Grant-in-Aid for Scientific Research 3,400,000Yen - Career history
2005-10 -- 2008-06 Hokkaido UniversityGraduate School of Pharmaceutical SciencesAssistant Professor 2008-06 -- 2015-03 Tohoku UniversityGraduate School of Life SciencesAssistant Professor 2015-04 -- (current) University of TsukubaFaculty of MedicineAssociate Professor - Academic background
1993-04 -- 1997-03 Kyoto university Faculty of pharmaceutical sciences 1997-04 -- 1999-03 Kyoto university Graduate School of Pharmaceutical Sciences 1999-04 -- 2002-03 Kyoto university Graduate School of Pharmaceutical Sciences - Degree
2002-07 博士(薬学) Kyoto university - Licenses and qualifications
1998-02-27 薬剤師 - Honors & Awards
2019-11 日本色素細胞学会奨励賞 2018-10 日本色素細胞学会 Best presentation賞 - Articles
- Ubiquitin-specific protease TRE17/USP6 promotes tumor cell invasion through the regulation of glycoprotein CD147 intracellular trafficking
Ogura Yukino; Ohbayashi Norihiko; Kanaho Yasunori; Kawagu...
JOURNAL OF BIOLOGICAL CHEMISTRY/298(9), 2022-09-01 - Recent advances in understanding the molecular basis of melanogenesis in melanocytes
Ohbayashi Norihiko; Fukuda Mitsunori
F1000Research/9, 2020-04 - TBC1D24 regulates recycling of clathrin-independent cargo proteins mediated by tubular recycling endosomes
Nguyen Thi Kim Nguyen; Ohbayashi Norihiko; Kanaho Yasuno...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS/528(1)/pp.220-226, 2020-07 - Unveiling the interaction between the molecular motor Myosin Vc and the small GTPase Rab3A
Dolce Luciano G; Ohbayashi Norihiko; Silva Daniel F C ...
Journal of proteomics/212, 2020-02 - Cytoplasmic control of Rab family small GTPases through BAG6
Takahashi Toshiki; Minami Setsuya; Tsuchiya Yugo; Taji...
EMBO reports/20(4), 2019-04 - SNARE dynamics during melanosome maturation
Ohbayashi Norihiko; Fukuda Mitsunori
Biochemical Society transactions/46(4)/pp.911-917, 2018-07 - LPA signaling mediates tumor lymphangiogenesis through promoting CRT expression in prostate cancer
Lin Yueh-Chien; Chen Chien-Chin; Chen Wei-Min; Lu Kua...
Biochimica et biophysica acta/1863(10)/pp.1305-1315, 2018-07 - Physiological function of phospholipase D2 in anti-tumor immunity: regulation of CD8 T lymphocyte proliferation
Ngo Thai Bich Van; Hongu Tsunaki; Miura Yuki; Katagiri N...
Scientific reports/8(1)/p.6283, 2018-04 - Regulation of HGF-induced hepatocyte proliferation by the small GTPase Arf6 through the PIP2-producing enzyme PIP5K1A
Tsai Meng-Tsz; Katagiri Naohiro; Ohbayashi Norihiko; Iwas...
Scientific reports/7(1)/p.9438, 2017-08 - Arf6 in lymphatic endothelial cells regulates lymphangiogenesis by controlling directional cell migration
Lin Yueh-Chien; Ohbayashi Norihiko; Hongu Tsunaki; Katagi...
Scientific reports/7(1), 2017-09 - The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses
Takahama Michihiro; Fukuda Mitsunori; Ohbayashi Norihi...
Cell reports/20(12)/pp.2944-2954, 2017-09 - The small G protein Arf6 expressed in keratinocytes by HGF stimulation is a regulator for skin wound healing
Miura Yuki; Ngo Thai Bich Van; Furuya Momoko; Hasegawa H...
Scientific Reports/(7)/p.46649, 2017-04 - Rab32 subfamily small GTPases: pleiotropic Rabs in endosomal trafficking
Ohbayashi Norihiko; Fukuda Mitsunori; Kanaho Yasunori
Journal of biochemistry/162(2)/pp.65-71, 2017-04 - C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia
Aoki Yoshitsugu; Manzano Raquel; Lee Yi; Dafinca Ruxa...
Brain : a journal of neurology/140(4)/pp.887-897, 2017-02 - ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons
Miura Yuki; Hongu Tsunaki; Yamauchi Yohei; Funakoshi Yuj...
BIOCHEMICAL JOURNAL/473(17)/pp.2591-2602, 2016-09 - A Varp-Binding Protein, RACK1, Regulates Dendrite Outgrowth through Stabilization of Varp Protein in Mouse Melanocytes
Marubashi Soujiro; Ohbayashi Norihiko; Fukuda Mitsunori
JOURNAL OF INVESTIGATIVE DERMATOLOGY/136(8)/pp.1672-1680, 2016-08 - Pathological functions of the small GTPase Arf6 in cancer progression: Tumor angiogenesis and metastasis.
本宮 綱記; 山内 庸平; 船越 祐司; 片桐 尚宏; 大林 典彦; 金保 安則
Small GTPases/7(2)/pp.47-53, 2016-04 - RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes
Marubashi Soujiro; Shimada Hikaru; Fukuda Mitsunori; Ohbayas...
JOURNAL OF BIOLOGICAL CHEMISTRY/291(3)/pp.1427-1440, 2016-01 - Activation of the Small G Protein Arf6 by Dynamin2 through Guanine Nucleotide Exchange Factors in Endocytosis
Okada Risa; Yamauchi Yohei; Hongu Tsunaki; Funakoshi Yuj...
SCIENTIFIC REPORTS/5, 2015-10 - Measurement of Rab35 activity with the GTP-Rab35 trapper RBD35.
Kobayashi Hotaka; Etoh Kan; Marubashi Soujiro; Ohbayashi Nor...
METHODS IN MOLECULAR BIOLOGY/1298/pp.207-216, 2015 - Rab40C is a novel Varp-binding protein that promotes proteasomal degradation of Varp in melanocytes
Yatsu Ayaka; Shimada Hikaru; Ohbayashi Norihiko; Fukuda Mits...
BIOLOGY OPEN/4/pp.267-275, 2015-03 - Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP
Ishida Morie; Ohbayashi Norihiko; Fukuda Mitsunori
SCIENTIFIC REPORTS/5/p.8238, 2015-02 - Atmospheric scanning electron microscope system with an open sample chamber: Configuration and applications
Nishiyama Hidetoshi; Koizumi Mitsuru; Ogawa Koji; Kitamur...
ULTRAMICROSCOPY/147/pp.86-97, 2014-12 - Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling
McGough Ian J.; Steinberg Florian; Gallon Matthew; Yatsu ...
JOURNAL OF CELL SCIENCE/127/p.4940, 2014-11 - Rab35 promotes the recruitment of Rab8, Rab13 and Rab36 to recycling endosomes through MICAL-L1 during neurite outgrowth
Kobayashi Hotaka; Etoh Kan; Ohbayashi Norihiko; Fukuda M...
BIOLOGY OPEN/3/pp. 803-814, 2014-09 - more...
- Ubiquitin-specific protease TRE17/USP6 promotes tumor cell invasion through the regulation of glycoprotein CD147 intracellular trafficking
- Books
- 小胞輸送
大林 典彦; 金保 安則
SEITAI NO KAGAKU/医学書院/pp.482-483, 2015-10 - メラノソーム形成とケラチノサイトへの輸送
石田森衛; 大林 典彦; 福田光則
色素細胞第2版/pp.44-58, 2015-08 - メラノソームの微小管逆行輸送機構 : 白髪予防の新たな分子標的
大林 典彦; 福田光則
特集 ヘアカラー製品のための技術開発と毛髪研究/フレグランスジャーナル/pp.30-35, 2014-03 - Rab GTPases and their roles in membrane traffic.
大林 典彦; 福田光則
領域融合レビュー/p.e006, 2013-05
- 小胞輸送
- Conference, etc.
- Ubiquitin-specific protease TRE17/USP6 promotes tumor cell invasion through the regulation of plasma membrane protein intracellular trafficking
小倉由希乃; 大林典彦; 金保安則; 川口敦史; 船越 祐司
第45回分子生物学会年会/2022-11-20--2022-12-02 - 脱ユビキチン化酵素TRE17/USP6は、CD147の細胞内輸送制御を介してがん細胞浸潤能を亢進する
船越 祐司; 小倉由希乃; 大林典彦; 川口敦史; 金保安則
第19回生命科学研究会/2022-07-01--2022-07-02 - Ubiquitin-specific protease TRE17/USP6 promotes cancer cell invasion through the regulation of plasma membrane protein recycling
小倉 由希乃; 川口 敦史; 大林典彦; 金保安則; 船越祐司
The 2020 NTU-KU-UT mini-symposium on Cancer Biology and Medicine/2021-12-19 - 脱ユビキチン化酵素TRE17/USP6による膜タンパク質の輸送制御を介した腫瘍細胞の浸潤促進機構脱ユビキチン化酵素TRE17/USP6による膜タンパク質の輸送制御を介した腫瘍細胞の浸潤促進機構
小倉由希乃; 川口敦史; 船越祐司; 大林典彦; 金保安則
第45回日本分子生物学会年会/2022-11-30--2022-12-02 - 脱ユビキチン化酵素TRE17と低分子量G蛋白質Arf6によるクラスリン非依存的カーゴ蛋白質の輸送制御.
小倉由希乃; 船越祐司; 大林典彦; 金保 安則
第41回日本分子生物学会年会/2018-11-29 - 脱ユビキチン化酵素TRE17と低分子量G蛋白質Arf6によるクラスリン非依存的カーゴ蛋白質の輸送制御.
小倉由希乃; 船越祐司; 大林典彦; 金保 安則
第41回日本分子生物学会年会/2018-11-29 - Regulation of clathrin-independent cargo trafficking by the ubiquitin-specific protease TRE17/USP6 and the small GTPase Arf6
小倉由希乃; 船越 祐司; 大林典彦; 金保安則
Tsukuba Global Science Week 2018/2018-9-20--2018-9-22 - Ubiquitin-specific protease TRE17/USP6 promotes cancer cell invasion through the regulation of plasma membrane protein recycling.
金保 安則; 船越祐司; 小倉由希乃; 大林典彦
筑波会議2019/2019-10-02--2019-10-04 - Ubiquitin-specific protease TRE17/USP6 promotes cancer cell invasion through the regulation of CD147 recycling.
Kanaho Yasunori; 船越祐司; 小倉由希乃; 大林典彦
The International Graduate Symposium on Industrial Biotechnology/2019-10-14--2019-10-19 - 脱ユビキチン化酵素TRE17/USP6は、膜蛋白質の輸送を介して癌細胞浸潤能を亢進する.
Kanaho Yasunori; 船越祐司; 小倉由希乃; 大林典彦
第42回分子生物学会年会/2019-12-03--2019-12-06 - The ubiquitin-specific protease TRE17/USP6 promotes cancer cell invasion through the regulation of plasma membrane protein recycling.
小倉由希乃; 大林典彦; 川口敦史; 金保 安則; 船越祐司
第72回日本細胞生物学会大会/2020-06-09--2020-06-11 - Ubiquitin-specific protease TRE17/USP6 promotes cancer cell invasion through the regulation of plasma membrane protein recycling
Funakoshi Yuji; 金保安則; 大林典彦
The 2020 NTU-KU-UT mini-symposium on Cancer Biology and Medicine/2021-12-19--2021-12-19 - 脱ユビキチン化酵素TRE17/USP6は膜蛋白質のリサイクリングを介して癌細胞浸潤能を亢進する
小倉 由希乃; 大林 典彦; 川口 敦史; 船越 祐司; 金保 安則
第43回日本分子生物学会/2020-12-02--2020-12-04 - BAG6 is a novel regulator for melanogenesis through controlling Rab32/38 stability
大林 典彦
第30回日本色素細胞学会学術大会/2021-10-23--2021-10-24 - Ubiquitin-specific protease TRE17/USP6 promotes cancer cell invasion through the regulation of plasma membrane protein recycling
Funakoshi Yuji; 金保安則; 大林典彦
The 2020 NTU-KU-UT mini-symposium on Cancer Biology and Medicine/2021-12-19--2021-12-19 - 脱ユビキチン化酵素TRE17/USP6は膜蛋白質のリサイクリングを介して癌細胞浸潤能を亢進する
小倉 由希乃; 大林 典彦; 川口 敦史; 船越 祐司; 金保 安則
第43回日本分子生物学会/2020-12-02--2020-12-04 - TBC1D24 regulates recycling of plasma membrane proteins that enter cells by clathrin-independent endocytosis.
Nguyen Thi Kim Nguyen; 大林典彦; 川口敦史; 金保 安則; 船越祐司
第72回日本細胞生物学会大会/2020-06-09--2020-06-11 - The ubiquitin-specific protease TRE17/USP6 promotes cancer cell invasion through the regulation of plasma membrane protein recycling.
小倉由希乃; 大林典彦; 川口敦史; 金保 安則; 船越祐司
第72回日本細胞生物学会大会/2020-06-09--2020-06-11 - 脱ユビキチン化酵素TRE17/USP6は、膜蛋白質の輸送を介して癌細胞浸潤能を亢進する.
Kanaho Yasunori; 船越祐司; 小倉由希乃; 大林典彦
第42回分子生物学会年会/2019-12-03--2019-12-06 - TBC1D24 regulates recycling of plasma membrane proteins that enter cells by clathrin-independent endocytosis.
Kanaho Yasunori; 船越祐司; Nguyen Nguyen Thi Kim; 大林典彦
第42回分子生物学会年会/2019-12-03--2019-12-06 - 小胞輸送が司るメラノソーム形成機構
大林 典彦
第29回日本色素細胞学会学術大会/2019-11-23--2019-11-24 - Ubiquitin-specific protease TRE17/USP6 promotes cancer cell invasion through the regulation of CD147 recycling.
Kanaho Yasunori; 船越祐司; 小倉由希乃; 大林典彦
The International Graduate Symposium on Industrial Biotechnology/2019-10-14--2019-10-19 - TBC1D24 regulates tubular recycling endosome formation through the small GTPase Rab22a.
Kanaho Yasunori; 船越祐司; Nguyen Nguyen Thi Kim; 大林典彦
筑波会議2019/2019-10-02--2019-10-04 - Ubiquitin-specific protease TRE17/USP6 promotes cancer cell invasion through the regulation of plasma membrane protein recycling.
金保 安則; 船越祐司; 小倉由希乃; 大林典彦
筑波会議2019/2019-10-02--2019-10-04 - 脱ユビキチン化酵素TRE17/USP6は、膜蛋白質の輸送を介して癌細胞浸潤能を亢進する.
金保 安則; 船越祐司; 小倉由希乃; 大林典彦
第18回生命科学研究会/2019-06-28--2019-06-29 - more...
- Ubiquitin-specific protease TRE17/USP6 promotes tumor cell invasion through the regulation of plasma membrane protein intracellular trafficking
- Teaching
2024-08 -- 2024-09 Agro-Biomedical Science Laboratory Seminar I University of Tsukuba. 2024-10 -- 2024-11 Research and Development for Agro-Biomedical Science I University of Tsukuba. 2024-10 -- 2024-12 Basic Molecular Nutrition University of Tsukuba. 2024-10 -- 2024-12 Global Issues and Global Society: Environmental Pollution and Health Effects University of Tsukuba. 2024-04 -- 2024-08 Seminar in Molecular Medical Sciences I University of Tsukuba. 2024-04 -- 2024-05 Invitation to Arts and Sciences University of Tsukuba. 2024-04 -- 2024-07 First Year Seminar University of Tsukuba. 2024-10 -- 2025-02 Seminar in Molecular Medical Sciences II University of Tsukuba. 2024-04 -- 2024-07 Clinical Pharmacology University of Tsukuba. 2024-04 -- 2024-08 Lecture and Discussion in Molecular Medical Sciences I University of Tsukuba. more... - Other educational activities
2020-11 -- 2020-11 高校生模擬授業 茨城県立竹園高校 2019-11 -- 2019-11 高校生模擬授業 茨城県立竹園高校 2017-08 -- 2017-08 Intensive courses for graduates Tokyo Metropolitan University - Talks
- メラノサイトにおけるメラノソーム輸送の仕組み
大林 典彦
スキンケア化粧品の最新技術-保湿、美白、シワ改善、機能性素材処方技術/2020-10-02--2020-10-02
- メラノサイトにおけるメラノソーム輸送の仕組み
- Professional activities
2019-11 -- (current) Japanese Society for Pigment Cell Research (JSPCR) 評議員 2014-07 -- (current) F1000Prime Associate Faculty member
(Last updated: 2022-08-23)