HIRAKAWA Hidehiko

Affiliation
Institute of Life and Environmental Sciences
Official title
Associate Professor
ORCID
0000-0003-0623-8573
Sex
Male
KAKEN ID
90451799
URL
Email
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Research fields
Biofunction/Bioprocess
Research keywords
Cytochrome P450
Protein engineering
Enzyme engineering
Research projects
ホモ多量体タンパク質を単量体タンパク質として扱うためのツールの開発2024-04 -- 2028-03平川 秀彦Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (C)4,550,000Yen
ゲル状多酵素複合体のサイズ制御2018-12 -- 2021-03平川 秀彦University of Tsukuba/研究基盤支援プログラム(Sタイプ)3,000,000Yen
Discovery of specific redox systems for bacterial cytochrome P450s2018-04 -- 2022-03Hidehiko HirakawaJapan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (C)4,290,000Yen
水溶性シトクロムP450の触媒活性に必須な電子伝達系の探索法の開発2016-04 -- 2017-03Hidehiko Hirakawaホクト生物科学振興財団/研究奨励金1,000,000Yen
Sequential enzyme complex formation on DNA2014-04 -- 2016-03Hidehiko Hirakawa日本学術振興会/Grant-in-Aid for Challenging Exploratory Research4,030,000Yen
自己集積する足場タンパク質を利用した人工セルロソーム2012-10 -- 2013-09Hidehiko Hirakawa積水化学/自然に学ぶものづくり研究助成プログラム1,000,000Yen
Staphylococcus aureus由来ソルテースA変異体を利用した細胞内蛋白質融合2012-04 -- 2013-03Hidehiko HirakawaJBA/化学素材研究開発振興財団記念基金「グラント」研究奨励金500,000Yen
足場タンパク質を利用したシトクロムP450の自己組織的な固定化2012-04 -- 2013-03Hidehiko Hirakawa旭硝子財団/平成24年度自然科学系「研究奨励」プログラム2,000,000Yen
細胞内における選択的なタンパク質連結法の開発2011-04 -- 2012-03Hidehiko Hirakawaみずほ学術振興財団/第54回工学研究助成2,000,000Yen
Complete Self-sufficient P450 with Cofactor Regeneration Domain2011-01 -- 2011-12Hidehiko Hirakawaノボザイムズ ジャパン/研究ファンド20111,000,000Yen
more...
Career history
2010-11 -- 2018-02The University of TokyoDepartment of Chemistry and Biotechnology, School of EngineeringAssistant Professor
2010-04 -- 2010-11The University of TokyoDepartment of Chemistry and Biotechnology, School of EngineeringProject Assistant Professor
2009-01 -- 2010-03The University of TokyoSchool of EngineeringProject Assistant Professor
2008-03 -- 2009-01The University of TokyoSchool of EngineeringProject postdoctoral fellow
2007-04 -- 2008-03The University of TokyoCenter for NanoBio IntegrationProject postdoctoral fellow
2005-04 -- 2007-03The University of KansasHiguchi Biosciences CenterPostdoctoral fellow
Academic background
2000-04 -- 2005-03The University of Tokyo School of Engineering Department of Chemistry and Biotechnology
1998-04 -- 2000-03The University of Tokyo Faculty of Engineering Department of Chemistry and Biotechnology
1996-04 -- 1998-03The University of Tokyo College of Arts and Sciences: Junior Division Natural Sciences I
Degree
2005-03博士(工学)The University of Tokyo
Academic societies
2013-01 -- (current)PROTEIN SCIENCE SOCIETY OF JAPAN
2008-04 -- (current)THE SOCIETY OF CEMICAL ENGINEERS, JAPAN
2007-10 -- (current)Japanese Society of Enzyme Engineering
2003-05 -- (current)The Society for Biotechnology, Japan
Honors & Awards
2017-10酵素工学奨励賞人為的な酵素の集合化に関する研究
2013-06研究奨励賞複数の電子伝達経路を有する人工シトクロムP450複合体
2013-03研究奨励賞【玉置明善記念賞】ボトムアップアプローチによる機能性タンパク質複合体の構築
2011-06FEBS Journal Klaus Ruckpaul poster awardArtificial self-sufficient P450: Noncovalent complex with electron transfer components
2011-05The outstanding award for Young Scientist and Student of oral presentationNoncovalent Complex Formation of a Bacterial Cytochrome P450 and its Electron transfer Proteins by Fusion to PCNA
Articles
Books
Conference, etc.
  • 酵素本来の力を引き出すためのアプローチ
    平川 秀彦
    第24回食品微細科学研究会講演会/2023-09-07
  • マルチウェルプレートを用いた Pseudomonas putida 由来シトクロム P450 と電子伝達タンパク質間相互作用の評価
    林 幹太; 平川 秀彦
    酵素工学研究会第90回講演会/2023-11-10
  • Metallosphaera sedula 由来 PCNA を利用したペプチド転移反応の制御
    多田 修平; 平川 秀彦
    酵素工学研究会第90回講演会/2023-11-10
  • Detection of interactions between cytochrome P450 and redox proteins using a Metallosphaera sedula scaffold protein
    Kuribayashi Kanta; Hirakawa Hidehiko
    2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics (2023 ICCP450/JSSX)/2023-09-27
  • Biotechnological applications based on insights from artificial assembly of cytochrome P450 and redox proteins
    Hirakawa Hidehiko
    2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics (2023 ICCP450/JSSX)/2023-09-27
  • Artificial proximity of electron transfer protein to cytochrome P450 opens a treasure chest"
    Hirakawa Hidehiko
    The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)/2021-12-16
  • Unorthodox Approach to Generate Self-sufficient Cytochrome P450
    Hirakawa Hidehiko
    10th Asian Biological Biological Inorganic Chemistry Conference/2022-12-02
  • Metallosphaera sedula由来核内増殖抗原を利用したシトクロムP450システムの不溶化
    渡邊 千晶; 平川 秀彦; 市川 創作
    酵素工学研究会第82回講演会/2019-11-01--2019-11-01
  • 人為的な近接化を利用したシトクロムP450camープチダレドキシン間相互作用の検出
    齋藤 航汰; 平川 秀彦; 市川 創作
    酵素工学研究会第82回講演会/2019-11-01--2019-11-01
  • Protein engineering for practical enzymatic protein/peptide ligation
    Hirakawa Hidehiko
    第19回日本蛋白質科学会年会 第71回日本細胞生物学会大会 合同年次大会/2019-06-24--2019-06-24
  • 複数の酸化還元ドメインを有する人工自己充足型シトクロムP450における電子伝達プロセスの解析
    平川 秀彦
    第31回生物無機化学夏季セミナー/2018-09-13--2018-09-13
  • What is happening in an artificial self-sufficient cytochrome P450?
    Hirakawa Hidehiko
    The 15th Japan-China-Korea Joint Symposium on Enzyme Engineering/2018-06-30--2018-07-02
  • 人為的な酵素の集合化に関する研究
    Hirakawa Hidehiko
    酵素工学研究会第78回講演会/2017-10-06--2017-10-06
  • 人工自己充足型シトクロムP450の速度論的解析
    芳賀 智亮; 平川 秀彦; 長棟 輝行
    化学工学会第49回秋季大会/2017-09-21--2017-09-21
  • 逐次的な多酵素複合体構築
    岩田 史也; 平川 秀彦; 長棟 輝行
    第69回日本生物工学会大会/2017-09-12--2017-09-12
  • Benefits from artificial assembly with redox partners
    Hirakawa Hidehiko
    20th International Conference on Cytochrome P450: Biochemistry, Biophysics and Biotechnology/2017-08-27--2017-08-31
  • 配列特異的なDNA結合タンパク質を用いた細菌由来シトクロムP450システムの再構成
    畠山 洋平; 平川 秀彦; 長棟 輝行
    化学工学会第82年会/2017-03-07--2017-03-07
  • Competitive detection of interaction between cytochrome P450 and electron transfer protein
    Kondo Masayoshi; Hirakawa Hidehiko; Nagamune Teruyuki
    The Fifth International Conference on Cofactors and Active Enzyme Molecule 2016/2016-09-07--2016-09-07
  • 黄色ブドウ球菌由来ペプチド転移酵素における基質阻害機構の解明と新規変異体の開発
    畠山 美沙樹; 平川 秀彦; 長棟 輝行
    化学工学会群馬大会2015/2015-11-27--2015-11-27
  • Artificial Assembly of Cytochrome P450 Monooxygenase and Auxiliary Proteins for Efficient Electron Supply
    Hirakawa Hidehiko
    錯体化学会第65回討論会/2015-09-21--2015-09-23
  • An artificial self-sufficient cytochrome P450 wakes up earlier with extra redox components
    Haga Tomoaki; Hirakawa Hidehiko; Nagamune Teruyuki
    Active Enzyme Molecule 2014/2014-12-19--2014-12-19
  • Identification of the electron transfer partner proteins that can activate P450 from Thermobifida fusca
    Kondo Masayoshi; Hirakawa Hidehiko; Nagamune Teruyuki
    Active Enzyme Molecule 2014/2014-12-19--2014-12-19
  • Design of an artificial cellulolytic multi-enzyme complex aligned by PTDH-linked PCNA heterotrimer units
    Schmitt Katharina; Hirakawa Hidehiko; Nagamune Teruyuki
    Active Enzyme Molecule 2014/2014-12-17--2014-12-17
  • Immobilization of cytochrome P450 and its redox protein partners coupled with cofactor regeneration
    Tan Cheau Yuaan; 渡辺 浩志; 平川 秀彦; 長棟 輝行
    化学工学会第79年会/2014-03-30--2014-03-30
  • PCNA heterotrimer mediated cluster formation of an artificial cellulosome complex
    Schmitt Katharina; 平川 秀彦; 長棟 輝行
    化学工学会第79年会/2014-03-18--2014-03-18
  • more...
Teaching
2023-04 -- 2023-08Master's Internship IIUniversity of Tsukuba.
2023-10 -- 2024-02Master's Internship IIUniversity of Tsukuba.
2023-04 -- 2023-09Life Science Innovation Master's Special Research I SpringUniversity of Tsukuba.
2023-04 -- 2023-05Invitation to Arts and SciencesUniversity of Tsukuba.
2023-10 -- 2024-03Life Science Innovation Master's Special Seminar II FallUniversity of Tsukuba.
2023-04 -- 2023-08Specialized Laboratory in Applied Biological ChemistryUniversity of Tsukuba.
2023-10 -- 2024-02Seminar in Life and Agricultural SciencesUniversity of Tsukuba.
2023-04 -- 2023-08Seminar in Life and Agricultural SciencesUniversity of Tsukuba.
2023-04 -- 2023-08Responsible Conduct of ResearchUniversity of Tsukuba.
2023-10 -- 2024-02Responsible Conduct of ResearchUniversity of Tsukuba.
more...
Talks
  • 酵素本来の力を引き出すためのアプローチ
    平川 秀彦
    第24回食品微細科学研究会講演会/2023-09-07
  • 酵素のかたちとはたらき
    平川 秀彦
    くらしの中の生化学-生きもののしくみを知るー/2022-08-27
  • Immobilization of Soluble Cytochrome P450 Monooxygenase
    Hirakawa Hidehiko
    T-LSI Symposium on Life Science Innovation and Biomaterials/2018-09-05--2018-09-05
Professional activities
2023-04 -- 2025-03The Society for Bioscience and Bioengineering, Japan代議員名
2021-06 -- (current)Journal of Bioscience and BioengineeringEditorial Board Member
2020-05 -- (current)Applied SciencesEditorial Board Member
2019-01 -- (current)Japanese Society of Enzyme Engineering幹事
2015-05 -- (current)Scientific Reports (Nature Publishing Group)Editorial Board Member
University Management
2021-05 -- (current)遺伝子組換え実験安全委員会委員
2018-04 -- (current)ライフイノベーション学位プログラム運営委員会委員
2019-04 -- 2019-11ライフイノベーション学位プログラム広報・連携委員会委員長
2018-04 -- (current)ライフイノベーション学位プログラムFD委員会委員長
2018-04 -- (current)ライフイノベーション学位プログラム教務委員会委員長
2018-04 -- 2019-03ライフイノベーション学位プログラム広報・連携委員会委員
Other activities
2018-09 -- 2018-09T-LSI Symposium on Life Science Innovation and Biomaterialsを開催

(Last updated: 2024-04-05)