Mukai Jun

Affiliation

University of Tsukuba

Official title

Professor

Research fields

General physiology

Research keywords

Precision medicine
Neuroscience, Psychiatry, 22q11.2 deletion syndrome, schizophrenia, Autism, Neurodevelopmental disease, Histone methylation

Research projects

統合失調症におけるヒストンメチルトランスフェラーゼSETD1Aの役割の解明	2019 -- 2021	向井 淳	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B)	17,420,000Yen

Career history

2018-07 -- (current)	University of TsukubaResearch and Development Center for Precision MedicineProfessor

Degree

1995-03	医学博士	三重大学

Articles

• Aberrant Cortical Ensembles and Schizophrenia-like Sensory Phenotypes in Setd1a(+/-) Mice
  Hamm Jordan P.; Shymkiv Yuriy; Mukai Jun; Gogos Joseph A...
  Biological Psychiatry in Press (https://www.biologicalpsychiatryjournal.com/article/S0006-3223(20)30009-3/fulltext)/88(3)/pp.215-223, 2020-08
• Recapitulation and reversal of schizophrenia-related phenotypes in Setd1a-deficient mice.
  向井 淳; Cannavo E.; Sun Z.; Crabtree G.; Diamantopoulou A....
  Neuron/104(3)/pp.471-487, 2019
• Loss-of-function mutation in rescues specific schizophrenia-related phenotypes in a mouse model of the 22q11.2 deletion
  Diamantopoulou Anastasia; Sun Ziyi; Mukai Jun; Xu Bin...
  Proceedings of the National Academy of Sciences of the United States of America/114(30)/p.E6127-E6136, 2017-04
  
  PubMed
• Developmental Inhibition of Gsk3 Rescues Behavioral and Neurophysiological Deficits in a Mouse Model of Schizophrenia Predisposition
  Tamura Makoto; Mukai Jun; Gordon Joshua A; Gogos Jose...
  Neuron/89(5)/pp.1100-1109, 2016-03
  
  PubMed
• Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome
  Piskorowski Rebecca A; Nasrallah Kaoutsar; Diamantopoul...
  Neuron/89(1)/pp.163-176, 2016-01
  
  PubMed
• Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia
  Mukai Jun; Tamura Makoto; Fénelon Karine; Rosen Andre...
  Neuron/86(3)/pp.680-695, 2015-05
  
  PubMed
• S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95
  Ho Gary P H; Selvakumar Balakrishnan; Mukai Jun; Heste...
  Neuron/71(1)/pp.131-141, 2011-07
  
  PubMed
• Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex
  Fénelon Karine; Mukai Jun; Xu Bin; Hsu Pei-Ken; Drew ...
  Proceedings of the National Academy of Sciences of the United States of America/108(11)/pp.4447-4452, 2011-03
  
  PubMed
• Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion
  Mukai Jun; Dhilla Alefiya; Drew Liam J; Stark Kimberl...
  Nature neuroscience/11(11)/pp.1302-1310, 2008-11
  
  PubMed
• Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice
  Paterlini Marta; Zakharenko Stanislav S; Lai Wen-Sung; ...
  Nature neuroscience/8(11)/pp.1586-1594, 2005-11
  
  PubMed
• Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia
  Mukai Jun; Liu Hui; Burt Rachel A; Swor Dionne E; Lai...
  Nature genetics/36(7)/pp.725-731, 2004-07
  
  PubMed

(Last updated: 2020-01-23)