向井 淳(ムカイ ジュン; Mukai, Jun)

所属

筑波大学

職名

教授

研究分野

生理学一般

研究キーワード

Precision medicine

Neuroscience, Psychiatry, 22q11.2 deletion syndrome, schizophrenia, Autism, Neurodevelopmental disease, Histone methylation

研究課題

統合失調症におけるヒストンメチルトランスフェラーゼSETD1Aの役割の解明

2019 -- 2021

向井 淳

日本学術振興会/基盤研究(B)

17,420,000円

職歴

2018-07 -- (現在)

筑波大学 プレシジョン・メディスン開発研究センター 教授

取得学位

1995-03

医学博士

三重大学

査読付き学術雑誌・国際会議論文

• Aberrant cortical ensembles and schizophrenia-like sensory phenotypes in setd1a mice.
  Mukai Jun
  Biological Psychiatry in Press (https://www.biologicalpsychiatryjournal.com/article/S0006-3223(20)30009-3/fulltext), 2020
• Recapitulation and reversal of schizophrenia-related phenotypes in Setd1a-deficient mice.
  向井 淳; Cannavo E.; Sun Z.; Crabtree G.; Diamantopoulou ...
  Neuron/104(3)/pp.471-487, 2019
• Loss-of-function mutation in rescues specific schizophrenia-related phenotypes in a mouse model of the 22q11.2 deletion
  Diamantopoulou Anastasia; Sun Ziyi; Mukai Jun; Xu Bin; Fe...
  Proceedings of the National Academy of Sciences of the United States of America/114(30)/p.E6127-E6136, 2017-04
  PubMed
• Developmental Inhibition of Gsk3 Rescues Behavioral and Neurophysiological Deficits in a Mouse Model of Schizophrenia Predisposition
  Tamura Makoto; Mukai Jun; Gordon Joshua A; Gogos Joseph A
  Neuron/89(5)/pp.1100-1109, 2016-03
  PubMed
• Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome
  Piskorowski Rebecca A; Nasrallah Kaoutsar; Diamantopoulou...
  Neuron/89(1)/pp.163-176, 2016-01
  PubMed
• Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia
  Mukai Jun; Tamura Makoto; Fénelon Karine; Rosen Andrew M;...
  Neuron/86(3)/pp.680-695, 2015-05
  PubMed
• S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95
  Ho Gary P H; Selvakumar Balakrishnan; Mukai Jun; Hester L...
  Neuron/71(1)/pp.131-141, 2011-07
  PubMed
• Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex
  Fénelon Karine; Mukai Jun; Xu Bin; Hsu Pei-Ken; Drew Liam...
  Proceedings of the National Academy of Sciences of the United States of America/108(11)/pp.4447-4452, 2011-03
  PubMed
• Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion
  Mukai Jun; Dhilla Alefiya; Drew Liam J; Stark Kimberly L;...
  Nature neuroscience/11(11)/pp.1302-1310, 2008-11
  PubMed
• Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice
  Paterlini Marta; Zakharenko Stanislav S; Lai Wen-Sung; Qi...
  Nature neuroscience/8(11)/pp.1586-1594, 2005-11
  PubMed
• Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia
  Mukai Jun; Liu Hui; Burt Rachel A; Swor Dionne E; Lai Wen...
  Nature genetics/36(7)/pp.725-731, 2004-07
  PubMed

(最終更新日: 2020-01-23)