Okada Kousuke
- Affiliation
- Faculty of Medicine
- Official title
- Associate Professor
- ORCID
- 0000-0003-4843-3465
- )FB8;8BFZieD;cKJLBL98c8:cAG
- Office
- Molecular Sportology
- Research fields
General medical chemistry Gastroenterology - Research keywords
Non-alcoholic steatohepatitis Hepatology - Research projects
NASH発症進展におけるp62の役割 - 脂肪酸代謝の臓器連関から視た解析 2021 -- 2023 岡田 浩介 日本学術振興会/科学研究費助成事業 基盤研究C 4,290,000Yen ヒト肝癌臨床検体を用いたNonalcoholic steatohepatitis (NASH) における肝発癌とその進展機構の解明 -Autophagy調節因子p62と酸化ストレス防御因子Nrf2に着目して- 2020 -- 2022 岡田 浩介 日本消化器病学会/臨床研究助成 3,000,000Yen 臓器連関の視点からの組織細胞特異的レスキューマウスを用いたNASH肝発癌機構解 2018 -- 2021 岡田 浩介 日本学術振興会/科学研究費助成事業 基盤研究C 4,420,000Yen 非アルコール性脂肪肝炎における転写因子Nrf2の役割と新しい治療への応用 2011 -- 2012 岡田 浩介 公益財団法人 中山がん研究所/第4回中山がん研究所消化器疾患研究助成 500,000Yen 胆汁うっ滞性肝疾患に対する転写因子Nrf2賦活化を介した新しい治療への応用 2010 -- 2011 岡田 浩介 公益信託永尾武難病研究基金/第12回永尾武難病研究基金助成 1,000,000Yen - Career history
2021-06 -- (current) 筑波大学医学医療系准教授 2017-04 -- 2021-05 筑波大学附属病院つくば予防医学研究センター病院講師 2015-03 -- 2017-03 日立おおみか病院医員 2012-08 -- 2015-02 Brigham and Women’s Hospital, Harvard Medical SchoolResearch fellow 2011-10 -- 2012-07 筑波大学医学医療系研究員 2009-04 -- 2011-09 筑波大学大学院人間総合科学研究科研究員 2003-04 -- 2005-03 筑波大学附属病院医員(研修医) 2002-04 -- 2003-03 水戸協同病院医員(研修医) 2001-10 -- 2002-03 つくばセントラル病院医員(研修医) 2000-10 -- 2001-09 日立製作所日立総合病院医員(研修医) more... - Academic background
2005-04 -- 2009-03 筑波大学大学院 人間総合科学研究科 1993-04 -- 1999-03 筑波大学 医学専門学群 - Degree
2009-03 博士(医学) 筑波大学大学院 - Academic societies
2019-06 -- (current) 日本ヘリコバクター学会 2017-09 -- (current) 日本消化器がん検診学会 2011-05 -- (current) 日本胆道学会 2005-04 -- (current) 日本肝臓学会 2002-02 -- (current) 日本消化器病学会 1999-06 -- (current) 日本内科学会 - Honors & Awards
2011-06 肝臓フォーラム(東部), 大正富山Award 2010-11 The 9th Japan Society of Hepatology Single Topic Conference 2010, Presidential Award - Articles
- Label-free assessment of renal function with unilateral ureteral obstruction (UUO) model by optical coherence microscopy
Mukherjee Pradipta; Fukuda Shinichi; Lukmanto Donny; Yama...
Proceedings Volume 11972, Label-free Biomedical Imaging and Sensing (LBIS) 2022, 2022-03 - Label-free assessment of renal function with unilateral ureteral obstruction (UUO) model by optical coherence microscopy.
P Mukherjee; S Fukuda; D Lukmanto; T Yamashita; K Okada; ...
Proc SPIE 11972, 2022-03 - The prevalence and clinical implications of pancreatic fat accumulation identified during a medical check-up.
Suzuki Hideo; K Okada; K Horie; T Takayama; Y Aida; T Sh...
Medicine/100(41)/p.e27487, 2021-10 - Relationships of Dietary Habits and Physical Activity Status with Non-Alcoholic Fatty Liver Disease Featuring Advanced Fibrosis
Okada Kosuke; Yabe Yoshito; Kim Taeho; Oh Sechang; Shida ...
Int J Environ Res Public Health/18(17)/p.8918, 2021-08 - Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography
Okada Kosuke; Mukherjee Pradipta; Miyazawa Arata; Fukuda ...
Sci Rep./11(1)/p.20054, 2021-10 - Prevention on non-alcoholic steatohepatitis by long-term exercise via the induction of phenotypic changes in Kupffer cells of hyperphagic obese mice.
Okada Kousuke; I Miura; S Komine; S Wada; E Warabi; F Uc...
Physiological Reports/9(9), 2021-05 - Inchinkoto, an herbal medicine, and its ingredients dually exerts Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers.
Okada Kousuke; J Shoda; M Kano; S Suzuki; Ohtake N; M Yam...
Americal Journal of physiology/292/pp.G1450-G1463, 2007 - Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue.
Okada Kousuke; KB LeClair; Y Zhang; Y Li; C Ozdemir; TI ...
MOLECULAR METABOLISM/5(5)/pp.340-351, 2016 - Prediction of true Helicobacter pylori-uninfected status using a combination of age, serum antibody and pepsinogen: Logistic regression analysis
Takayama Takako; Suzuki Hideo; Okada Kosuke; Yamada Take...
PloS one/15(10), 2020-04 - Clinical and Anthropometric Characteristics of Non-obese NAFLD Subjects in Japan
Shoda Junichi; Shida Takashi; Oshida Natsumi; Suzuki Hid...
Hepatology Research/50(9)/pp.1032-1046, 2020-07 - Gender difference in development of steatohepatitis in p62/Sqstm1 and Nrf2 double-knockout mice
Watahiki Takahisa; Okada Kosuke; Warabi Eiji; Nagaoka Ts...
Experimental animals/69(4)/pp.395-406, 2020-06 - Urinary Levels of Titin-N Fragment, a Skeletal Muscle Damage Marker, are Increased in Subjects with Nonalcoholic Fatty Liver Disease
Oshida Natsumi; Shida Takashi; Oh Sechang; Kim Taeho; Iso...
Scientific reports/9/p.19498, 2019-12 - Progressive reduction in skeletal muscle mass to visceral fat area ratio is associated with a worsening of the hepatic conditions of non-alcoholic fatty liver disease
Shida Takashi; Oshida Natsumi; Oh Sechang; Okada Kosuke; ...
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy/12/pp.495-503, 2019-3 - Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis
Akiyama Kentaro; Warabi Eiji; Okada Kosuke; Yanagawa Tor...
Experimental Animals/67(2)/pp.201-218, 2017-12 - Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet.
Okada Kosuke; Warabi Eiji; Sugimoto Hirokazu; Horie Masa...
Journal of gastroenterology/48(5)/pp.620-632, 2013-05 - Deficiency of p62/Sequestosome 1 Causes Hyperphagia Due to Leptin Resistance in the Brain
Harada Harumi; Warabi Eiji; Matsuki Taizo; Yanagawa Toru...
JOURNAL OF NEUROSCIENCE/33(37)/pp.14767-14777, 2013-09 - Amelioration of cisplatin-induced nephrotoxicity in peroxiredoxin I-deficient mice
Okada Kosuke; Ma Dongmei; Warabi Eiji; Morito Naoki; Akiy...
CANCER CHEMOTHERAPY AND PHARMACOLOGY/71(2)/pp.503-509, 2013-02 - Nrf2 Counteracts Cholestatic Liver Injury via Stimulation of Hepatic Defense Systems.
Okada K.; Shoda J.; Taguchi K.; Maher J.M.; Ishizaki K.; ...
Biochem Biophys Res Commun/389(3)/pp.431-436, 2009-01 - Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis
Okada Kosuke; Warabi Eiji; Sugimoto Hirokazu; Horie Masa...
JOURNAL OF GASTROENTEROLOGY/47(8)/pp.924-935, 2012-08 - The α-glucosidase inhibitor acarbose prevents obesity and simple steatosis in sequestosome 1/A170/p62 deficient mice
OKADA Kosuke; YANAGAWA Toru; WARABI Eiji; YAMASTU Keiko; ...
Hepatol Res/39(5)/pp.490-500, 2009-05 - Bezafibrate induces multidrug-resistance P-Glycoprotein 3 expression in cultured human hepatocytes and humanized livers of chimeric mice
Shoda Junichi; Okada Kosuke; Inada Yoichi; Kusama Hirosh...
HEPATOLOGY RESEARCH/37(7)/pp.548-556, 2007-07 - Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts
Harada Harumi; Sugimoto Rika; Watanabe Ayaka; Taketani S...
FREE RADICAL RESEARCH/42(4)/pp.297-304, 2008-01 - Hypointense gallbladder on MR cholangiopancreatography
Ishige Kazunori; Okada Kohsuke; Kikuchi Norihiro; Satoh ...
HEPATO-GASTROENTEROLOGY/55(82-83)/pp.333-333, 2008-03 - Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice
Okada Kosuke; Shoda Junichi; Taguchi Keiko; Maher Jonath...
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY/295(4)/pp.0-0, 2008-10 - Choleretic effect of inchinkoto, a herbal medicine, on livers of patients with biliary obstruction due to bile duct carcinoma
Watanabe Shinya; Yokoyama Yukihiro; Oda Koji; Kokuryo To...
HEPATOLOGY RESEARCH/39(3)/pp.247-255, 2009-03 - more...
- Label-free assessment of renal function with unilateral ureteral obstruction (UUO) model by optical coherence microscopy
- Conference, etc.
- Assessment of renal functional changes in obstructed nephropathy using optical coherence tomography
Mukherjee Pradipta; Fukuda Shinichi; Lukmanto Donny; Yama...
Optics and Photonics Japan/2021 - 3D label-free metabolic imaging in non-alcoholic fatty liver disease model by optical coherence microscopy
Mukherjee Pradipta; Fukuda Shinichi; Lukmanto Donny; Yama...
Optics and Photonics Japan/2021 - Label-free assessment of renal function with unilateral ureteral obstruction (UUO) model by optical coherence microscopy
Mukherjee Pradipta; Fukuda Shinichi; Lukmanto Donny; Yama...
Photonics West/2022-2-22 - 肝細胞のp62はマウス脂肪性肝炎を防御する -組織細胞特異的p62遺伝子改変マウスの解析より
岡田 浩介
第108回消化器病学会総会/2022-04-21--2022-04-23 - 骨格筋のp62は筋-肝連関を介して脂肪性肝炎の炎症・線維化を抑制する
岡田 浩介; 石井 亜紀子; 正田 純一; 三浦 征
第108回消化器病学会総会/2022-04-21--2022-04-23 - NASH進行とNASH肝癌におけるautophagy調節因子p62の役割
岡田 浩介; 石毛 和紀; 鈴木 英雄; 有泉 俊一; 山本 雅一; 正田 純一; 陶 経緯; 綿引 隆久; 有泉...
JDDW 2021/2021-11-04--2021-11-06 - レドックスナノ粒子(RNP)はNASHモデルの肝線維化および肝癌を抑止する.
岡田 浩介; 正田 純一; 綿引 隆久
JDDW 2021/2021-11-04--2021-11-06 - レドックスナノ粒子(RNP)は脂肪性肝炎モデルにおける肝線維化と発癌を抑止する.
岡田 浩介; 正田 純一; 綿引 隆久
第57回肝臓学会総会/2021-06-17--2021-06-19 - p62およびNrf2遺伝子二重欠失マウスは,腸内細菌叢の変化に関連したlipopolysaccharide増加により脂肪性肝炎を自然発症する
岡田 浩介; 正田 純一; 綿引 隆久
第107回消化器病学会総会/2021-04-15--2021-04-17 - レドックスナノ粒子(RNP)はp62:Nrf2遺伝子二重欠失マウス脂肪性肝炎における線維化を抑止する
岡田 浩介; 正田 純一; 綿引 隆久
第107回消化器病学会総会/2021-04-15--2021-04-17 - p62/SQSTM1 in hepatocytes plays a protective role against the development of steatohepatitis in mice.
Okada Kosuke; Shoda Junichi; Watahiki Takahisa
JDDW2021, Kobe/2021-11-04--2021-11-04 - ヘリコバクターピロリ未感染予測式による未感染診断精度の妥当性の検討
高山 敬子; 鈴木 英雄; 岡田 浩介; 秋山 慎太郎; 奈良坂 俊明; 坂本 琢; 土屋 輝一郎
第108回日本消化器病学会総会/2022-04-21--2022-04-23 - たこいぼ状隆起の関連因子についての検証
鈴木 英雄; 岡田浩介; 高山敬子
第63回日本消化器病学会大会(JDDW2021)/2021-11-04
- Assessment of renal functional changes in obstructed nephropathy using optical coherence tomography
- Teaching
2022-05 -- (current) 医学概論 筑波大学 2022-02 -- (current) 医学検査学フロンティア 筑波大学 2021-12 -- (current) 病態検査学 筑波大学 2021-10 -- (current) 医療科学概論 筑波大学 2021-10 -- (current) Practice of Clinical Biochemistry University of Tsukuba. 2021-11 -- (current) Practice of Clinical Laboratory University of Tsukuba. 2021-07 -- (current) Clinical Laboratory Science University of Tsukuba. 2021-07 -- (current) Laboratory Instrumentation University of Tsukuba. 2021-10 -- (current) Laboratory Informatics University of Tsukuba.
(Last updated: 2022-07-21)