南雲 康行(ナグモ ヤスユキ; Nagumo, Yasuyuki)

所属

国際統合睡眠医科学研究機構

職名

助教

職歴

2007-04 -- 2015-03	東京女子医科大学 医学部 助教
2007-05 -- 2008-08	自然科学研究機構　生理学研究所 神経シグナル研究部門 共同利用研究員

学歴

1998-04 -- 2002-03	星薬科大学 薬学部 衛生薬学科	卒業
2002-04 -- 2004-03	星薬科大学大学院 博士課程前期	修了
2004-04 -- 2007-03	星薬科大学大学院 博士課程後期	修了

取得学位

2007-03

博士 (薬学)

星薬科大学

所属学協会

-- (現在)	日本神経科学学会
-- (現在)	日本緩和医療薬学会
-- (現在)	鎮痛薬・オピオイドペプチド研究会

論文

• Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine
  Nagumo Yasuyuki; Katoh Koki; Iio Keita; Saitoh Tsuyoshi; ...
  Bioorganic & medicinal chemistry letters/30(17), 2020-06
• Tonic GABAergic Inhibition Is Essential for Nerve Injury-Induced Afferent Remodeling in the Somatosensory Thalamus and Ectopic Sensations
  Nagumo Yasuyuki; Ueta Yoshifumi; Nakayama Hisako; Osaki H...
  Cell reports/31(12), 2020-06
  PubMed
• Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine
  Nagumo Yasuyuki; Katoh Koki; Iio Keita; Saitoh Tsuyoshi; ...
  Bioorganic & Ｍedicinal Chemistry Letters/30(17), 2020-09
  PubMed
• Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities
  Kutsumura N.; Koyama Y.; Saitoh T.; Yamamoto N.; Nagumo Y...
  Molecules/25(5)/pp.1112-1112, 2020-03
  PubMed
• Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities
  Kutsumura N.; Koyama Y.; Saitoh T.; Yamamoto N.; Nagumo Y...
  Molecules/25(5), 2020-03
  Tsukuba Repository
• Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group
  Saito Tsuyoshi; Seki Kazunori; Nakajima Ryo; Yamamoto Nao...
  Bioorg. Med. Chem. Lett./30(3), 2019-12
  PubMed
• Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity
  Saitoh Tsuyoshi; Seki Kazunori; Nakajima Ryo; Yamamoto Na...
  Bioorganic & medicinal chemistry letters/29(18)/pp.2655-2658, 2019-09
  PubMed
• Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring
  Yamamoto Naoshi; Ohrui Sayaka; Okada Takahiro; Saitoh Tsu...
  Bioorganic & medicinal chemistry/27(8)/pp.1747-1758, 2019-04
  PubMed
• A NOVEL REARRANGEMENT REACTION OF MORPHINAN TO ARYLMORPHAN SKELETONS AND THE PHARMACOLOGIES OF ARYLMORPHAN DERIVATIVES
  Yata Masahiro; Kutsumura Noriki; Nagumo Yasuyuki; Yamamot...
  HETEROCYCLES/99(1)/pp.134-144, 2019-04
• SYNTHESIS OF NOVEL 1,3-DIOXA-5-THIAZATRIQUINANE AND 1-OXA-3,5-DITHIAZATRIQUINANE DERIVATIVES AND THEIR PHARMACOLOGIES
  Ohshita Ryuichiro; Kutsumura Noriki; Nagumo Yasuyuki; Yam...
  HETEROCYCLES/97(2)/pp.687-695, 2018-09
• Favorskii-Type Rearrangement of the 4,5-Epoxymorphinan Skeleton
  Kutsumura Noriki; Koyama Yasuaki; Suzuki Yuko; Tominaga K...
  Organic letters/20(6)/pp.1559-1562, 2018-03
  PubMed
• Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity
  Ohrui Sayaka; Yamamoto Naoshi; Saitoh Tsuyoshi; Kutsumura...
  Bioorganic & Medicinal Chemistry Letters/28(4)/pp.774-777, 2017-12
  PubMed
• Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor
  Yamamoto Naoshi; Ohrui Sayaka; Okada Takahiro; Yata Masah...
  Bioorganic & medicinal chemistry letters/27(17)/pp.4176-4179, 2017-09
  PubMed
• Synthesis of heterocyclic compounds with adamantane-like cage structures consisting of phosphorus, sulfur, and carbon
  Kutsumura Noriki; Ohshita Ryuichiro; Horiuchi Jumpei; Tat...
  TETRAHEDRON/73(34)/pp.5214-5219, 2017-08
  Tsukuba Repository
• Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives
  Kutsumura Noriki; Koyama Yasuaki; Nagumo Yasuyuki; Nakaji...
  Bioorganic & medicinal chemistry/25(16)/pp.4375-4383, 2017-08
  PubMed
• The κ-Opioid Receptor Agonist Nalfurafine Enhances the Chemotherapy-induced Survival Advantage in Pancreatic Cancer-bearing Mice
  HAMADA Yusuke; TASAKI Yoshihiko; MORITA Kana; YAMAMIZU Ko...
  日本緩和医療薬学雑誌 = Japanese journal of pharmaceutical palliative care and sciences/10(1)/pp.7-12, 2017-03
  CiNii
• Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies
  Nagase Hiroshi; Yamamoto Naoshi; Yata Masahiro; Ohrui Say...
  JOURNAL OF MEDICINAL CHEMISTRY/60(3)/pp.1018-1040, 2017-02
  PubMed
• The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus
  Narushima Madoka; Uchigashima Motokazu; Yagasaki Yuki; Ha...
  Neuron/91(5)/pp.1097-1109, 2016-09-07
  PubMed
• Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain
  Nakajima Ryo; Yamamoto Naoshi; Hirayama Shigeto; Iwai Tak...
  BIOORGANIC & MEDICINAL CHEMISTRY/23(19)/pp.6271-6279, 2015-10
  PubMed
• Rewiring of afferent fibers in the somatosensory thalamus of mice caused by peripheral sensory nerve transection
  Takeuchi Yuichi; Yamasaki Miwako; Nagumo Yasuyuki; Imoto ...
  The Journal of neuroscience : the official journal of the Society for Neuroscience/32(20)/pp.6917-6930, 2012-05-16
  PubMed
• Synapse- and subtype-specific modulation of synaptic transmission by nicotinic acetylcholine receptors in the ventrobasal thalamus
  Nagumo Yasuyuki; Takeuchi Yuichi; Imoto Keiji; Miyata Mariko
  Neuroscience research/69(3)/pp.203-213, 2011-03-01
  PubMed
• [Effects of fasudil on neuropathic pain-like state in mice]
  Shiokawa Mitsuru; Yamaguchi Takanori; Narita Minoru; Okut...
  Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology/27(4)/pp.153-159, 2007-08-01
  PubMed
• Role of spinal voltage-dependent calcium channel alpha 2 delta-1 subunit in the expression of a neuropathic pain-like state in mice
  Narita Minoru; Nakajima Mayumi; Miyoshi Kan; Narita Michi...
  Life sciences/80(22)/pp.2015-2024, 2007-05
  PubMed
• Chronic pain-induced astrocyte activation in the cingulate cortex with no change in neural or glial differentiation from neural stem cells in mice
  Kuzumaki Naoko; Narita Minoru; Narita Michiko; Hareyama N...
  Neuroscience letters/415(1)/pp.22-27, 2007-03-19
  PubMed
• Implication of protein kinase C in the orexin-induced elevation of extracellular dopamine levels and its rewarding effect
  Narita Minoru; Nagumo Yasuyuki; Miyatake Mayumi; Ikegami ...
  The European journal of neuroscience/25(5)/pp.1537-1545, 2007-03-01
  PubMed

more...

担当授業科目

2020-11 -- 2020-12	創薬化学概論	筑波大学
2019-11 -- 2019-12	創薬化学/薬理学	筑波大学
2018-11 -- 2018-12	創薬化学/薬理学	筑波大学
2017-11 -- 2017-12	創薬化学/薬理学	筑波大学

(最終更新日: 2020-07-28)