ERNA Raja(エルナ ラジャ)

所属
生存ダイナミクス研究センター
職名
助教
研究分野
実験病理学
研究課題
Exploring the role of fibulin 7 as an anti-inflammatory ECM in psoriasis2023-04 -- 2026-03ERNA Raja日本学術振興会/Grant-in-Aid for Scientific Research(C)4,550,000円
Elucidating the mechanism of stiff skin in a novel Fbn1 mutant mice and its relation to wound healing2022-09 -- 2023-04Erna RajaLydia O`leary Memorial Pias Dermatological Foundation/Elastin molecular research grant 2022
Defining the mechanism of epidermal stem cells heterogeneity2020-09 -- 2023-03ERNA Raja日本学術振興会/Grant -in-Aid for Research Activity Start-up2,860,000円
EPHA6 as a potential biomarker in glioblastoma2019-04 -- 2019-07Erna Raja日本学術振興会/Grant-in-Aid for Early Career Scientists
学歴
2008-10 -- 2012-10Uppsala University Ludwig Institute for Cancer Research Molecular Cell Biology
取得学位
2012-10Ph.DUppsala University
所属学協会
2014 -- 2019日本癌学会
2022 -- (現在)日本研究皮膚科学会
2019 -- (現在)日本分子生物学会
2019 -- (現在)日本生化学会
論文
  • Fibrillin-1 G234D mutation in the hybrid1 domain causes tight skin associated with dysregulated elastogenesis and increased collagen cross-linking in mice
    Hossain ASM Sakhawat; Clarin Maria Thea Rane Dela Cruz; ...
    MATRIX BIOLOGY, 2024-11
  • A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta
    Kimura Kenichi; Motoyama Eri; Kanki Sachiko; Asano Ke...
    Biorxiv, 2024-05-07
  • Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin
    Raja Erna; Clarin Maria Thea Rane Dela Cruz; Yanagisawa...
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES/24(18)/p.14274, 2023-09
  • The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging
    Erna Raja
    cold spring harbor Biorxiv, 2022-03
  • Regulating the stability of TGFbeta receptors and Smads
    P Lönn; A Morén; Erna Raja; M Dahl; A Moustakas
    Cell Research, 2009-01
  • Identification of a novel fusion gene HMGA2-EGFR in glioblastoma
    A Komuro; Erna Raja; C Iwata; M Soda; K Isogaya; K Yuki; ...
    International Journal of Cancer, 2018-04
  • PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma-initiating cell properties via DNA methyltransferase 3A
    R Tanabe; K Miyazono; T Todo; N Saito; C Iwata; A Komuro...
    Molecular oncology, 2022-01
  • Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1
    Morén A; Erna Raja; Heldin CH; Moustakas A
    Journal of Biological Chemistry, 2011-01
  • RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer
    QC Lau; Raja Erna; M Salto-Tellez; Q Liu; K Ito; M Inoue...
    Cancer research, 2006-07
  • Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells
    Erna Raja; A Komuro; R Tanabe; S Sakai; Y Ino; N Saito; T...
    Oncogene, 2017-08
  • Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase
    P Lönn; M Vanlandewijck; Erna Raja; M Kowanetz; Y Watana...
    Journal of Biological Chemistry, 2012-04
  • The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling
    Erna Raja; K Tzavlaki; R Vuilleumier; K Edlund; K Kahata...
    Oncotarget, 2016-01
  • Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output
    Erna Raja; Kolliopoulos C Raja E Razmara M Heldin P ...
    Journal of Biological Chemistry, 2019-03
  • Tyrosine kinase Eph receptor A6 sensitizes glioma-initiating cells towards bone morphogenetic protein-induced apoptosis
    Erna Raja; Morikawa M Nishida J Tanabe R Takahashi K ...
    Cancer Science, 2019-11
  • Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging
    Oinam Lalhaba; Changarathil Gopakumar; ERNA RAJA; Ngo ...
    Aging cell, 2020-08
  • Mechanisms of action of bone morphogenetic proteins in cancer
    H Davis; ERNA RAJA; K Miyazono; Y Tsubakihara; A Moustakas
    Cytokine and Growth Factor Reviews, 2016-02
  • The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging
    RAJA ERNA; Changarathil Gopakumar; Oinam Lalhaba; Tsun...
    EMBO REPORTS/23(12), 2022-10
会議発表等
  • Fibrillin-1 G234D mutation links mouse skin tightness to elastic fiber defects and collagen cross-linking
    Hossain ASM Sakhawat; Cruz Maria Thea Rane Dela; Kimura...
    第56回日本結合組織学会学術大会/2024-06-15--2024-06-16
  • Elucidating the Role of Anti-aging Matrix Fibulin 7 in Skin Inflammatory Disease Psoriasis
    Erna Raja
    Tissue, Matrix, and Pathobiology: Joint Meeting of ASMB, HCS, and ASIP/2023-10-22--2023-10-25
  • A Novel Mutation in the Hybrid1 Domain of the Fibrillin 1 Gene Causes Tight Skin Phenotype
    ASM Sakhawat Hossain; Maria Thea Rane Dela Cruz; Koichi...
    第7回エラスチン・関連分子研究会学術集会/2023-11-23--2023-11-24
  • A Novel Mutation in the Hybrid1 Domain of the Fibrillin 1 Gene Causes an Abnormal Skin Phenotype
    ASM Sakhawat Hossain; Yuki Taga; Maria Thea Rane Dela ...
    Tissue, Matrix, and Pathobiology: Joint Meeting of ASMB, HCS, and ASIP/2023-10-23--2023-10-26
  • The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging
    Erna Raja
    第９５回日本生化学大会/2022-11-09--2022-11-11
  • Fibulin 7 maintains epidermal stem cell heterogeneity during skin aging
    Erna Raja
    エラスチン・関連分子研究会/2022-11-22--2022-11-23

(最終更新日: 2024-08-30)