Kato Kosuke

Affiliation

Faculty of Medicine

Official title

Assistant Professor

Research fields


Molecular biology

Research projects


細胞老化とSASP遺伝子発現制御におけるクロマチン制御因子TAF-Iの機能解析	2021 -- 2023	加藤広介	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C)	4,160,000Yen
細胞老化とSASP遺伝子発現制御におけるクロマチン制御因子TAF-Iの機能解析	2021-04 -- 2024-03	加藤広介	Japan Society of for the Promotion of Science/科研費　基盤研究（C)	4,160,000Yen
クロマチン制御因子TAF-Iによるヒトテロメアの構造と機能の制御機構	2018-04 -- 2021-03	加藤広介	Japan Society of for the Promotion of Science/Grant-in-Aid for Scientific Research(C)	4,420,000Yen
新規の遺伝子治療に向けた人工ヌクレアーゼとクロマチンの機能ダイナミクス研究	2017-04 -- 2019-03	加藤広介	独立行政法人　日本学術振興会/二国間交流事業共同研究
ヒストンH1ユビキチン化によるゲノム安定性制御機構	2015-04 -- 2016-03	加藤　広介	日本学術振興会/若手研究（B)	3,770,000Yen
ヒストンＨ１ユビキチン化によるゲノム安定性制御機構	2014-04 -- 2015-03	加藤　広介	Japan Society for the Promotion of Science/若手研究(B)	3,770,000Yen

Academic societies


-- (current)	The Molecular Biology Society of Japan

Articles

ARHGAP1 Transported with Influenza Viral Genome Ensures Integrity of Viral Particle Surface through Efficient Budozone Formation
Kuroki Takahiro; Hatta Tomohisa; Natsume Tohru; Sakai No...
MBIO/13(3), 2022-04
Translational models of 3-D organoids and cancer stem cells in gastric cancer research
Wuputra Kenly; Ku Chia-Chen; Kato Kohsuke; Wu Deng-Ch...
STEM CELL RESEARCH & THERAPY/12(1), 2021-09
Template activating factor-I epigenetically regulates the TERT transcription in human cancer cells
Kato Kohsuke; Kawaguchi Atsushi; Nagata Kyosuke
SCIENTIFIC REPORTS/11(1), 2021-09
Therapeutic Strategies Targeting Tumor Suppressor Genes in Pancreatic Cancer
Kuo Kung-Kai; Hsiao Pi-Jung; Chang Wen-Tsan; Chuang S...
CANCERS/13(15), 2021-08
Deletion of Jdp2 enhances Slc7a11 expression in Atoh-1 positive cerebellum granule cell progenitors in vivo
Ku Chia-Chen; Wuputra Kenly; Kato Kohsuke; Pan Jia-Bi...
STEM CELL RESEARCH & THERAPY/12(1), 2021-06
Dimethyl sulfoxide stimulates the AhR-Jdp2 axis to control ROS accumulation in mouse embryonic fibroblasts
Wuputra Kenly; Tsai Ming-Ho; Kato Kohsuke; Yang Ya-Ha...
Cell biology and toxicology/Epub, 2021-03
PubMed
Jdp2-deficient Granule Cell Progenitors in the Cerebellum Are Resistant to ROS-mediated Apoptosis Through xCT/Slc7a11 Activation
Ku Chia-Chen; Wuputra Kenly; Kato Kosuke; Lin Wen-Hsin; P...
Scientific Reports/10(1), 2020-03
PubMed
Mitotic phosphorylation of CCCTC-binding factor (CTCF) reduces its DNA binding activity
Sekiya Takeshi; Murano Kensaku; Kato Kohsuke; Kawaguchi ...
FEBS open bio, 2017-01
Involvement of CTCF in transcription regulation of EGR1 at early G1 phase as an architecture factor
Sekiya Takeshi; Kato Kohsuke; Kawaguchi Atsushi; Nagata ...
Scientific reports, 2019-01
Involvement of CTCF in transcription regulation of EGR1 at early G1 phase as an architecture factor
Sekiya Takeshi; Kato Kohsuke; Kawaguchi Atsushi; Nagata ...
Scientific reports, 2019-01
Assembly and remodeling of viral DNA and RNA replicons regulated by cellular molecular chaperones.
Sekiya Takeshi; Hu Yifan; Kato Kohsuke; Okuwaki Mitsuru; ...
Biophysical Reviews, 2018-04
Involvement of CTCF in transcription regulation of EGR1 at early G1 phase as an architecture factor
Sekiya Takeshi; Kato Kohsuke; Kawaguchi Atsushi; Nagata ...
Scientific reports/9(1)/p.329, 2019-01
PubMed Tsukuba Repository
Histone H1 chaperone activity of TAF-I is regulated by its subtype-dependent intramolecular interaction
Kajitani Kaori; Kato Kosuke; Nagata Kyosuke
Genes Cells, 2017-04
Mitotic phosphorylation of CCCTC-binding factor (CTCF) reduces its DNA binding activity
Sekiya Takeshi; Murano Kensaku; Kato Kohsuke; Kawaguchi ...
FEBS open bio/7(3)/pp.397-404, 2017-03
PubMed Tsukuba Repository
Glucocorticoids facilitate the transcription from the human cytomegalovirus major immediate early promoter in glucocorticoid receptor- and nuclear factor-I-like protein-dependent manner
Inoue-Toyoda Maki; Kato Kosuke; Nagata　Kyosuke; Yoshikawa Hi...
Biochem Biophys Res Commun, 2015-02
Involvement of Nucleocytoplasmic Shuttling of Yeast Nap1 in Mitotic Progression
Mary Miyaji-Yamaguchi; Kohsuke Kato; Ryosuke Nakano; Tomo...
Molecular and Cellular Biology/23(18)/p.6672-6684, 2003-01
Gene silencing and histone modification by JDP2, a repressor that binds to the AP-1 regulatory sequence, during the differentiation of F9 embryonic carcinoma cells
Bingbing Liu; Takahito Yamasaki; Chunyuan Jin; Koji Naka...
Current Topics in Genetics/1/p.1-17, 2005-01
Assembly and Disassembly of Nucleosome Core Particles Containing Histone Variants by Human Nucleosome Assembly Protein I
Mitsuru Okuwaki; Kohsuke Kato; Hideto Shimahara; Shin-ich...
Molecular and Cellular Biology/25(23)/p.10639-10651, 2005-01
Assaying of nucleosome-assembly and histone acetyltransferase-inhibition (HAT-inhibition)
Takehide Murata; Chunyuan Jin; Kohsuke Kato; Takahito Ya...
Nature Protocols/p.DOI: 10.1038/nprot.2007., 2007-01
Involvement of Template Activating Factor-I as a chaperone in linker histone dynamics
Kohsuke Kato; Mitsuru Okuwaki; Kyosuke Nagata
Journal of Cell Science/124(19)/pp.3254-3265, 2011-10
PubMed
Histone acetylation-independent transcription stimulation by a histone chaperone
Kato Kohsuke; Miyaji-Yamaguchi Mary; Okuwaki Mitsuru; Nag...
NUCLEIC ACIDS RESEARCH/35(3)/pp.705-715, 2007-02
PubMed
Functional characterization of human nucleosome assembly protein 1-like proteins as histone chaperones
Okuwaki Mitsuru; Kato Kohsuke; Nagata Kyosuke
GENES TO CELLS/15(1)/pp.13-27, 2010-01
PubMed
Synergistic action of MLL, a TRX protein with template activating factor-I, a histone chaperone
Shimoyama T; Kato K; Miyaji-Yamaguchi M; Nagata K
FEBS LETTERS/579(3)/pp.757-762, 2005-01
PubMed
Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I
Okuwaki M; Kato K; Shimahara H; Tate S; Nagata K
MOLECULAR AND CELLULAR BIOLOGY/25(23)/pp.10639-10651, 2005-12
PubMed
Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2
Jin CY; Kato K; Chimura T; Yamasaki T; Nakade K; Murata ...
NATURE STRUCTURAL & MOLECULAR BIOLOGY/13(4)/pp.331-338, 2006-04

Books

The progress in the study of reprogramming to acquire the features in stem cells in iPSCs and cancers
Saito Shigeo; Wuputra Kenly; Kato Kosuke; Yokoyama Kazun...
Recent Advances in iPSC Technology, 2021-03
ヒストン/酸性分子シャペロンTAF-Iによるクロマチンからの転写制御機構
加藤広介
2007-07
クロマチンと遺伝子機能制御
加藤広介
2003-01
細胞核の世界
加藤広介
蛋白質核酸酵素・共立出版, 2006-11
転写因子・転写制御キーワードブック
加藤広介
2006-01
DNA Structure, Chromatin and Gene Expression
加藤広介
2006-01
転写制御とエピジェネティクス‐ゲノムデコードに向けて‐
加藤広介
2008-12
細胞核‐遺伝情報制御と疾患-
加藤広介
実験医学・羊土社, 2009-11
目的別で選べるタンパク質発現プロトコール
加藤広介
実験医学別冊・羊土社, 2010-04

Conference, etc.

天然変性タンパク質SSX1の新規機能が引き起こすクロマチンリモデリング異常のメカニズム
高橋花南; 堀越直樹; 谷一寿; 宮ノ入洋平; 古寺哲幸; 西村正宏; 加藤広介; 竹中聡; 胡桃...
第45回日本分子生物学会年会/2022-11-30--2022-12-2
天然変性タンパク質SSX1の新規機能が引き起こす滑膜肉腫発生メカニズム
高橋花南; 堀越直樹; 谷一寿; 宮ノ入洋平; 古寺哲幸; 西村正宏; 加藤広介; 竹中聡; 胡桃...
第95回生化学大会/2022-11-9--2022-11-11
天然変性タンパク質が引き起こす滑膜肉腫発生の新規メカニズム
高橋花南; 堀越直樹; 谷一寿; 宮ノ入洋平; 古寺哲幸; 西村正宏; 加藤広介; 竹中聡; 胡桃...
第60回生物物理学会年会/2022-09-28--2022-09-30
天然変性領域で構成される SSX1 の新規機能から明らかになった滑膜肉腫発生のメカニズム
高橋花南; 堀越直樹; 谷一寿; 宮ノ入洋平; 古寺哲幸; ⻄村正宏; 加藤広介; 竹中聡; 胡...
第48回生体分子科学討論会/2022-6-30--2022-7-1
Structural analysis of the c-terminal region of SSX1 harboring the potential DNA-binding site
高橋花南; 古寺哲幸; 宮ノ入洋平; 加藤広介; 西村正宏; 堀越直樹; 胡桃坂仁志; 竹中聡; 岩崎...
第22回日本蛋白質科学会年会/2022-06-07--2022-06-09
Influenza viral budozone formation in concert with vesicular transport of viral genome ensures functional integrity of virions for immune evasion
黒木崇央; 加藤広介; 永田恭介; 川口敦史
第68回日本ウイルス学会学術集会/2021
ヒストンH1シャペロンTAF-Iの分子内相互作用による活性制御機構
Kajitani Kaori; Kato Kosuke; Kyosuke Nagata
BMB2015/2015-12-01--2015-12-04
ヒストンH1ユビキチン化によるG1-S遺伝子群の転写制御
Kato Kosuke; Kyosuke Nagata
BMB2015/2015-12-01--2015-12-04
TAF-Iによるアデノウイルスコア複合体及び細胞性クロマチンの構造変換機構
鍛谷　香織; 加藤広介; 永田　恭介
第2回感染コンピテンシー若手研究会～ウイルス研究者の"新リベラルアーツ”～/2015-07-17--2015-07-18
Involvement of histone H1 ubiquitination in post replicative chromatin maintenance
加藤広介
Melbourne, Australia/2014-02-19--2014-02-22
ユビキチン化によるヒストンH1の機能制御
加藤広介
第31回　染色体ワークショップ/第12回　核ダイナミクス研究会/2013-11-25--2013-11-27
In　cellulo　analysis　of　parvovirus-mediated　changes　of　nuclear　envelope　integrity　by real time microscopy.
Snoussi Kenza; Kawaguchi Atsushi; Kato Kohsuke; Wodrich Hara...
Leading Graduate Schools International Conference/2013-10-02--2013-10-04

Teaching


2022-10 -- 2023-02	Basic Experiments in Human Biology	University of Tsukuba.
2022-04 -- 2022-08	Advanced Exercise on Public Health	University of Tsukuba.
2022-10 -- 2023-02	Advanced Exercise on Public Health	University of Tsukuba.
2022-04 -- 2022-08	Basic Experiments in Human Biology	University of Tsukuba.
2022-04 -- 2022-06	Clinical Microbiology	University of Tsukuba.
2022-10 -- 2022-12	Oncology	University of Tsukuba.
2022-10 -- 2022-12	Virology	University of Tsukuba.
2022-10 -- 2022-10	Practice of Clinical Microbiology II	University of Tsukuba.
2022-10 -- 2023-02	Basic Medical Sciences	University of Tsukuba.
2022-04 -- 2022-08	Basic Medical Sciences	University of Tsukuba.
more...

Talks

ヒストンH1結合因子によるクロマチン動態制御機構
加藤広介
第10回　核ダイナミクス研究会/2011-10-27
TAF-I is a linker histone chaperone in the mammalian somatic cell nucleus
加藤広介
BMB2010/2010-12-07
TAF-I, a novel somatic linker histone chaperone, is involved in chromatin dynamics
加藤広介
9th EMBL Conference Transcription and Chromatin/2010-08-29

University Management


2015-04 -- (current)	フロンティア医科学学生相談担当委員
2012-04 -- 2020-03	フロンティア医科学広報委員	入試説明会担当他

Other activities


2017-09 -- 2017-09	TGSW2017　セッションオーガナイザー（Transboader Networking in Human Biology)

(Last updated: 2022-05-30)