HO Kiong(ホー キョン)

所属

医学医療系

職名

准教授

URL

http://www.md.tsukuba.ac.jp/basic-med/kiongho/

eメール

564:923:N]Y8/W?>@6@-,W,.W5;d

研究分野

寄生虫学（含衛生動物学）
機能生物化学
分子生物学

研究キーワード

Parasitology, RNA Processing, RNA ligation, Trypanosoma

研究課題

Structure and biological targets of Trypanosome mRNA recapping enzyme	2021 -- 2023	HO KIONG	日本学術振興会/基盤研究(C)	4,290,000円
Mechanism of mRNA recapping pathway in trypanosome	2016-04 -- 2020-03	HO KIONG	日本学術振興会/科研費/基盤研究（B）	14,320,000円
Structural, Functional and Genetic Analysis of Archaea RNA Ligase	2011-04 -- 2016-03	Kiong Ho	アメリカ国立科学財団/Div Of Molecular and Cellular Bioscience	76,500,000円
Mechanism of mRNA cap formation in Trypanosoma brucei	2006-07 -- 2011-06	HO KIONG	アメリカ心臓協会/Scientist Development Grant	26,000,000円
Mechanism of Archaeal RNA ligase	2007-07 -- 2008-09	HO KIONG	University at Buffalo/UB2020 Interdisciplinary Research Development Fund	4,000,000円

職歴

2003-01 -- 2010-10	ニューヨーク州立大学、バッファロー校Department of Biological Sciences助教授
2000-01 -- 2003-10	スローンケタリンがん研究所Program in Molecular Biology主任研究員
1997-04 -- 1999-12	スローンケタリンがん研究所(米国)Program in Molecular BiologyPost-doctoral Fellow

学歴

1986-09 -- 1990-01	米国ラトガース大学　ニュージャージー州立大学 College of Arts and Sciences 生物化学
1990-09 -- 1997-03	米国コーネル大学医科学大学院 分子生物 Ph.D. 分子生物

取得学位

1997-02	Ph.D. Molecular Biology	米国コーネル大学医科学大学院
1990-1	Bachelor of Arts, Biochemistry	ラトガーズ、ニュージャージ州立大学

所属学協会

2020-01 -- 2020-12	American Society for Biochemistry and Molecular Biology
1997-01 -- 2020-12	ASM (American Society of Microbiology)
2017-04 -- (現在)	日本寄生虫学会
2007-01 -- 2020-03	RNA Society (International)
2017-04 -- (現在)	日本RNA学会

論文

• Trypanosome mRNA recapping is triggered by hypermethylation originating from cap 4
  HO Kiong
  Nucleic Acids Research, 2024-07
  
  PubMed
• Factors Affecting Undergraduate Medical Science Students’ Motivation to Study during the COVID-19 Pandemic
  Mayers Thomas David; Mathis Bryan J.; Ho C. Kiong; Morika...
  Education Sciences/12(9), 2022-09
  
  Tsukuba Repository
• Editorial: mRNA Translational Control as a Mechanism of Post-transcriptional Gene Regulation
  Kiss L. Daniel; Vasudevan Deepika; Ho Kiong; Caliskan Neva
  FRONTIERS IN MOLECULAR BIOSCIENCES/9, 2022-06
• Genetic and functional analyses of archaeal ATP-dependent RNA ligase in C/D box sRNA circularization and ribosomal RNA processing
  Liu Yancheng; Takagi Yuko; Sugijanto Milyadi; Nguyen Kie...
  FRONTIERS IN MOLECULAR BIOSCIENCES/9, 2022-03
  
  PubMed
• The impact of the COVID-19 pandemic on medical science students’ motivation to study: Preliminary findings
  Mayers Thomas David; Mathis Bryan J; Ho Kiong; Morikawa ...
  Journal of Medical English Education./20(3)/pp.52-55, 2021-10
• An essential surface motif (WAQKW) of yeast RNA triphosphatase mediates formation of the mRNA capping enzyme complex with RNA guanylyltransferase
  Ho Kiong; Lehman Kevin; Shuman Stewart
  Nucleic Acids Research/27(24)/pp.4671-4678, 1999-01
  
  PubMed
• Advanced Topics in Biotechnology and Medicine: An intensive literature-based course to encourage critical thinking in science and build academic English skills
  Ho C. Kiong; Mayers Thomas David; Morikawa Kazuya; Watana...
  Journal of Medical English Education/20(3)/pp.39-46, 2021-10
• Involving high school students in medical science exchange programs: Experiences from the University of Tsukuba
  Mayers Thomas; Morikawa Kazuya; Fukuda Aya; Watanabe Yuk...
  J Med Eng Educ/19(1)/pp.40-44, 2020-02
• Crystal structures of the RNA triphosphatase from Trypanosoma cruzi provide insights into how it recognizes the 5' end of the RNA substrate
  Takagi Yuko; Kuwabara Naoyuki; Dang Truong Tat; Furukawa ...
  Journal of Biological Chemistry/295(27)/pp.9076-9086, 2020-05
  
  PubMed Tsukuba Repository
• Mutational Analyses of Yeast RNA Triphosphatases Highlight a Common Mechanism of Metal-dependent NTP Hydrolysis and a Means of Targeting Enzymes to Pre-mRNAs in Vivo by Fusion to the Guanylyltransferase Component of the Capping Apparatus
  Pei Yi; Ho Kiong; Schwer Beate; Shuman Stewart
  Journal of Biological Chemistry/274(41)/pp.28865-28874, 1999-10
• An international exchange program for undergraduate medical science students.
  Mayers Thomas; Morikawa Kazuya; Ho Kiong; Ohneda Osamu
  J Med Eng Educ/17(1)/pp.7-13, 2018-04
• Cleavage of 3'-terminal adenosine by archaeal ATP-dependent RNA ligase
  Yoshinari Shigeo; Liu Yancheng; Gollnick Paul; Ho C Kiong
  Scientific reports/7(1), 2017-09
  
  PubMed Tsukuba Repository
• Structural and mutational analysis of archaeal ATP-dependent RNA ligase identifies amino acids required for RNA binding and catalysis
  Gu H; Yoshionari S; Ghosh R; Ignatochkina AV; Gollnick PD; Mur...
  Nucleic acids research/44(5)/pp.2337-2347, 2016-03
  
  PubMed Tsukuba Repository
• Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase
  Paul Smith; Ho Kiong; Yuko Takagi; Hakim Djaballah; Stewart S...
  mBIO/7(1)/p.10.1128/mBio.00058-16, 2016-02
  
  PubMed Tsukuba Repository
• Teaching science and learning English: an introduction to the Molecular Biology Course in Vietnam
  Ho Kiong
  The Journal of Medical English Education/14(3)/pp.93-98, 2015-10
• The messenger RNA decapping and recapping pathway in Trypanosoma
  Ignatochkina AV; Takagi Y; Liu Y; Negate K; Ho Kiong
  Proceedings of the National Academy of Sciences USA/112(22)/pp.6967-6972, 2015-06
  
  PubMed
• Archaea RNA Ligase is a Homodimeric Protein that Catalyzes Intramolecular Ligation of Single-Stranded RNA and DNA.
  Torchea C Takagi Y and Ho CK.
  Nucleic Acid Research/36/p.6218-6227, 2008-01
• Distinct RNA Elements Confer Specificity to Flavivirus RNA Cap Methylation Events.
  Dong H; Ray D; Ren S; Zhang B; Puig-Basagoiti F; Takagi ...
  J. Virol./81/p.4412-4421, 2007-01
• Trypanosoma brucei Encodes a Bifunctional Capping Enzyme Essential for Cap 4 Formation on the Spliced Leader RNA.
  Takagi Y Sindkar S Ekonomidis D Hall MP and Ho CK.
  J. Biol. Chem/282/p.15995-16005, 2007-01
• Characterization of a Trypanosoma brucei mRNA Cap (Guanine N-7) Methyltransferase.
  Hall MP and Ho CK.
  RNA/12/p.488 -497, 2006-01
• Functional Characterization of a 48-kDa Trypanosoma brucei Cap 2 RNA Methyltransferase.
  Hall MP and Ho CK.
  Nucleic Acid Research/34/p.5594 - 5602, 2006-01
• Identification of the MicroRNAs of the Herpesvirus Family.
  Pfeffer S Sewer A Lagos-Quintana M Sheridan R Sander...
  Nature Method/2/p.269-276, 2005-01
• Structure and Mechanism of RNA Ligase.
  Ho CK Wang LK Lima CD and Shuman S.
  Structure/12/p.327-339, 2004-01
• Portability and Fidelity of RNA Repair Systems.
  Schwer B; Sawaya R; Ho CK; Shuman S.; +HO KIONG
  Proc. Natl. Acad. Sci. USA/101/p.2788-2793, 2004-01
• Characterization of Bacteriophage KVP40 and T4 RNA Ligase 2.
  Yin S Ho CK Miller ES and Shuman S.
  Virology/319/p.141-151, 2004-01
• さらに表示...

著書

• Detection and Identification of Uncapped RNA by Ligation-Mediated Reverse Transcription Polymerase Chain Reaction
  Ho Kiong
  Methods Molecular Biology/Humana Press, New York, NY/pp.1-9, 2017-08
  
  PubMed

会議発表等

• University of Tsukuba Joint Symposium in Biomedical Science
  Ho Kiong
  The 3rd University of Science – University of Tsukuba Joint Symposium in Biomedical Science/2023-02-18--2023-02-18
• The Identification and Characterization of RNA Recapping Targets in Trypanosomes
  Ho Kiong
  The 3rd University of Science – University of Tsukuba Joint Symposium in Biomedical Science/2023-02-18--2023-02-18
• Unique Cap-dependent RNA Methyltransferase activity in Trypanosoma brucei
  Ho Kiong
  第23回日本RNA学会年会/2022-07-20--2022-07-22
• Circularization of C/D Box sRNA by Archaeal ATP-Dependent RNA Ligase.
  Ho Kiong
  第23回日本RNA学会年会/2022-07-20--2022-07-22
• Modification Beyond the Hypermethylated Cap 4 Structure in Trypanosoma Spliced Leader RNA
  Ho Kiong
  第92回日本寄生虫学会大会/2023-03-30--2023-03-31
• Medical science summer research program in the University of Tsukuba in the era of COVID-19
  Mayers Thomas David; Ho C. Kiong
  第 55 回日本医学教育学会大会/2023-07-28--2023-07-29
• The impact of the COVID-19 pandemic on medical science students’ motivation to study
  Mayers Thomas David; Mathis Bryan James; Ho C. Kiong; Mor...
  日本医学英語教育学会学術集会/2021-07-17--2021-07-18
• Purification of a Putative Cap-dependent RNA Methyltransferase in Trypanosoma brucei
  Ho Kiong; Anna Ignatochkina
  第3回つくば精製フォーラム/2021-02-19--2021-02-19
• Regulation of Protozoa Gene Expression by mRNA Recapping Pathway
  Ho Kiong
  The 2nd Joint Young Researcher Meeting in Biomedical Sciences/2020-01-10--2020-01-11
• トリパノソーマRNA triphosphataseの結晶構造解析による三リン酸ならびに核酸認識機構の解明
  Ho Kiong; Takagi Yuko; Kuwabara Naoyuki; Truong Dang; Fur...
  第42回日本分子生物学会/2019-12-03--2019-12-06
• Involving high school students in medical science exchange programs: Experiences from the University of Tsukuba
  Mayers Thomas David; Ho Kiong; Fukuda Aya; Watanabe Yuki...
  第22回日本医学英語教育学会学術集会/2019-08-03--2019-08-04
• Involving high school students in medical science exchange programs: Experiences from the University of Tsukuba
  Mayers Thomas David; Ho Kiong; Fukuda Aya; Watanabe Yuki...
  第22回日本医学英語教育学会学術集会/2019-08-03--2019-08-04
• Targeting of mRNA Cap Formation for Treatment of Parasitic Infections
  Ho Kiong
  The Joint Symposium in Infectious Diseases/2019-02-22--2019-02-22
• Structural and Functional Analysis of protozoan mRNA capping enzyme
  HO KIONG
  第20回日本RNA学会年会/2018-07-09--2018-07-12
• The messenger RNA recapping pathway in Trypanosome
  Ho Kiong
  第88回日本寄生虫学会大会/2019-03-14--2019-03-16
• Structural and Functional Analysis of Trypanosoma RNA Triphosphatase
  HO KIONG
  第88回日本寄生虫学会大会/2019-03-14--2019-03-16
• RNA methylation at the 5’-end of the mRNA stimulates Trypanosoma mRNA recapping activities
  Ho Kiong
  Cold Spring Harbor Meeting, Translational Control Meeting/2018-09-04--2018-09-08
• Structure and mechanism of archaeal ATP-dependent RNA ligase
  Ho Kiong; Yoshinari Shigeo; Murakami Katsuhiko S.
  Cutting Edge Developments in RNA Biology for the Control of Gene Expression/2017-11-13--2017-11-17
• Messenger RNA recapping enzyme is regulated by hypermethylation at the 5’-end of the RNA
  Ho Kiong; Ignatochkina Anna V.; Iguchi Jesavel; Kore Ani...
  Cutting Edge Developments in RNA Biology for the Control of Gene Expression/2017-11-13--2017-11-17
• Molecular Mechanism of mRNA Recapping in Trypanosome
  HO KIONG
  2017年度生命科学系学会合同年次大会/2017-12-06--2017-12-09
• Identification and characterization of a novel 5'-monophosphate RNA kinase in Trypanosoma brucei
  Ho Kiong
  21th Annual RNA Society Meeting/2016-06-28--2016-07-02
• Recapping the Message: The mRNA Decapping and Recapping Pathway in Trypanosomes
  Ho Kiong
  21th Annual RNA Society International Meeting/2016-06-28--2016-07-02
• Inhibitor Screening Against Trypanosoma cruzi RNA Triphosphatase
  Ho Kiong; Takagi Yuko; Kuwabara Naoyuki; Tani Osamu; Saka...
  Kinetoplastid Molecular Cell Biology 2017/2017-04-22--2017-04-26
• Archaea RNA Ligase is Required for Circularizing Small Non-Coding RNA.
  Ho Kiong; Liu Yancheng; Takagi Yuko; Hirata Akira; Hori ...
  第１９回日本RNA学会/2017-07-19--2017-07-21
• Trypanaosome mRNA recapping activity is modulated by hypermethylation derived from cap 4 structure
  Ho Kiong; Ignatochkina Anna V.; Iguchi Jesavel; Kore Ani...
  第１９回日本RNA学会/2017-07-19--2017-07-21

担当授業科目

2023-10 -- 2024-02	感染症医科学演習	筑波大学
2023-10 -- 2024-02	Seminars on Global Issues B-I	筑波大学
2024-01 -- 2024-02	専門語学(英語)P	筑波大学
2023-10 -- 2024-02	ヒューマンバイオロジー基礎実験	筑波大学
2023-04 -- 2023-08	ヒューマンバイオロジー研究 III	筑波大学
2023-10 -- 2024-02	ヒューマンバイオロジー研究 III	筑波大学
2023-10 -- 2024-02	国際実践医科学研究特論III	筑波大学
2023-04 -- 2023-08	国際実践医科学研究特論III	筑波大学
2023-10 -- 2024-02	国際実践医科学研究特論II	筑波大学
2023-04 -- 2023-08	国際実践医科学研究特論II	筑波大学
さらに表示...

授業以外の教育活動

2022-02 -- 2022-02	感染生物ワークショップ
2022-10 -- 2022-10	Summer Research Program Plus 2022	フロンティア医科学
2022-07 -- 2022-07	Summer Research Program Online 2022
2023-02 -- 2023-02	Undergraduate Medical Science Course in Tsukuba
2022-02 -- 2022-02	Medical Science Course in Tsukuba Online	医療科学
2021-09 -- 2021-09	医学サマーリサーチプログラムオンライン
2020-10 -- 2021-01	BIOINFORMATICS IN GENOMICS: Data analysis in high-throughput sequencing	Masafumi Muratani, Kiong Ho
2020-12 -- 2021-02	Academic Communications. Presenting, Writing, Discussng	Thomas Mayers, Kiong Ho
2020-01 -- 2020-01	Transcriptosome Analysis, Experimental Course in Biotechnology and Medicine	University of Indonesia Medical Campus
2020-01 -- 2020-01	University of Medicine and Pharmacy, Vietnam	University of Medicine and Pharmacy, Vietnam
さらに表示...

一般講演

• Purification of a Putative Cap-dependent RNA Methyltransferase in Trypanosoma brucei
  Ho Kiong; Anna Ignatochkina
  第3回つくば精製フォーラム/2021-02-19--2021-02-19
• Structure and Mechanism of RNA Repair Enzymes
  Ho Kiong
  生命と機能とかたち/2018-03-07--2018-03-07

学内管理運営業績

2018-04 -- (現在)	全学 学群教育課程委員会	委員
2020-04 -- (現在)	全学 国際交流支援室企画・審査委員会	委員
2020-04 -- (現在)	全学 海外生教育プログラム等検討委員会	委員
2018-04 -- (現在)	全学 国際戦略委員会	委員
2021-04 -- (現在)	医学医療系　国際連携委員会	委員長
2021-04 -- (現在)	医学医療系　企画委員会	委員
2019-04 -- (現在)	ヒューマンバイオロジープログラム 学位審査委員会	委員長
2014-04 -- (現在)	ヒューマンバイオロジープログラム　広告委員会	委員
2013-04 -- (現在)	ヒューマンバイオロジープログラム　国際連携委員会	委員
2020-04 -- (現在)	医学学位プログラム 国際推進委員会	委員
さらに表示...

その他の活動

2021-04 -- (現在)	Frontiers in Molecular Bioscience - Associate Editor

(最終更新日: 2024-07-17)