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HO KIONG(ホー キョン; Ho, Kiong)

所属
医学医療系
職名
准教授
URL
eメール
 
研究分野
寄生虫学（含衛生動物学）
機能生物化学
分子生物学
研究キーワード
Parasitology, RNA Processing, RNA ligation, Trypanosoma
研究課題
Mechanism of mRNA recapping pathway in trypanosome2016-04 -- 2020-03HO KIONG日本学術振興会/科研費/基盤研究（B）14,320,000円
Structural, Functional and Genetic Analysis of Archaea RNA Ligase2011-04 -- 2016-03Kiong Hoアメリカ国立科学財団/Div Of Molecular and Cellular Bioscience76,500,000円
Mechanism of mRNA cap formation in Trypanosoma brucei2006-07 -- 2011-06HO KIONGアメリカ心臓協会/Scientist Development Grant26,000,000円
Mechanism of Archaeal RNA ligase2007-07 -- 2008-09HO KIONGUniversity at Buffalo/UB2020 Interdisciplinary Research Development Fund4,000,000円
職歴
2003-01 -- 2010-10ニューヨーク州立大学、バッファロー校 Department of Biological Sciences 助教授
2000-01 -- 2003-10スローンケタリンがん研究所 Program in Molecular Biology 主任研究員
1997-04 -- 1999-12スローンケタリンがん研究所(米国) Program in Molecular Biology Post-doctoral Fellow
学歴
1986-09 -- 1990-01米国ラトガース大学　ニュージャージー州立大学 生命理工学部 B.A. 生物化学卒業
1990-09 -- 1997-03米国コーネル大学医科学大学院 分子生物 Ph.D. 分子生物卒業
所属学協会
1997-01 -- (現在)ASM (American Society of Microbiology)
2017-04 -- (現在)日本寄生虫学会
2007-01 -- (現在)RNA Society (International)
2017-04 -- (現在)日本RNA学会
論文
  • Involving high school students in medical science exchange programs: Experiences from the University of Tsukuba
    Mayers Thomas; Morikawa Kazuya; Fukuda Aya; Watanabe Yuki...
    J Med Eng Educ/19(1)/pp.40-44, 2020-02
  • Crystal structures of the RNA triphosphatase from Trypanosoma cruzi provide insights into how it recognizes the 5' end of the RNA substrate
    Ho Kiong; Takagi Yuko; Kuwabara Naoyuki; Dang Truong Tat;...
    Journal of Biological Chemistry/295(27)/pp.9076-9086, 2020-05
    PubMed Tsukuba Repository
  • An international exchange program for undergraduate medical science students.
    Mayers Thomas; Morikawa Kazuya; Ho Kiong; Ohneda Osamu
    J Med Eng Educ/17(1)/pp.7-13, 2018-04
  • Cleavage of 3'-terminal adenosine by archaeal ATP-dependent RNA ligase
    Yoshinari Shigeo; Liu Yancheng; Gollnick Paul; Ho C Kiong
    Scientific reports/7(1), 2017-09
    PubMed Tsukuba Repository
  • Structural and mutational analysis of archaeal ATP-dependent RNA ligase identifies amino acids required for RNA binding and catalysis
    Gu H; Yoshionari S; Ghosh R; Ignatochkina AV; Gollnick PD...
    Nucleic acids research/44(5)/pp.2337-2347, 2016-03
    PubMed Tsukuba Repository
  • Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase
    Paul Smith; Ho Kiong; Yuko Takagi; Hakim Djaballah; Stewa...
    mBIO/7(1)/p.10.1128/mBio.00058-16 , 2016-02
    PubMed Tsukuba Repository
  • Teaching science and learning English: an introduction to the Molecular Biology Course in Vietnam
    Ho Kiong
    The Journal of Medical English Education/14(3)/pp.93-98, 2015-10
  • The messenger RNA decapping and recapping pathway in Trypanosoma
    Ignatochkina AV; Takagi Y; Liu Y; Negate K; Ho Kiong
    Proceedings of the National Academy of Sciences USA/112(22)/pp.6967-6972, 2015-06
    PubMed
  • The messenger RNA decapping and recapping pathway in Trypanosoma
    Anna Ignatochkina; Yuko Takagi; Yancheng Liu; Kyosuke Nag...
    Proc. Natl. Acad. Sci. U. S. A./112(22)/pp.6967-6972, 2015-06
    PubMed
  • Archaea RNA Ligase is a Homodimeric Protein that Catalyzes Intramolecular Ligation of Single-Stranded RNA and DNA.
    Torchea C Takagi Y and Ho CK.
    Nucleic Acid Research/36/p.6218-6227, 2008-01
  • Distinct RNA Elements Confer Specificity to Flavivirus RNA Cap Methylation Events.
    Dong H; Ray D; Ren S; Zhang B; Puig-Basagoiti F; Takagi Y...
    J. Virol./81/p.4412-4421, 2007-01
  • Trypanosoma brucei Encodes a Bifunctional Capping Enzyme Essential for Cap 4 Formation on the Spliced Leader RNA.
    Takagi Y Sindkar S Ekonomidis D Hall MP and Ho CK.
    J. Biol. Chem/282/p.15995-16005, 2007-01
  • Characterization of a Trypanosoma brucei mRNA Cap (Guanine N-7) Methyltransferase.
    Hall MP and Ho CK.
    RNA/12/p.488 -497, 2006-01
  • Functional Characterization of a 48-kDa Trypanosoma brucei Cap 2 RNA Methyltransferase.
    Hall MP and Ho CK.
    Nucleic Acid Research/34/p.5594 - 5602, 2006-01
  • Identification of the MicroRNAs of the Herpesvirus Family.
    Pfeffer S Sewer A Lagos-Quintana M Sheridan R Sander C Gr...
    Nature Method/2/p.269-276, 2005-01
  • Structure and Mechanism of RNA Ligase.
    Ho CK Wang LK Lima CD and Shuman S.
    Structure/12/p.327-339, 2004-01
  • Portability and Fidelity of RNA Repair Systems.
    Schwer B; Sawaya R; Ho CK; Shuman S.; +HO KIONG
    Proc. Natl. Acad. Sci. USA/101/p.2788-2793, 2004-01
  • Characterization of Bacteriophage KVP40 and T4 RNA Ligase 2.
    Yin S Ho CK Miller ES and Shuman S.
    Virology/319/p.141-151, 2004-01
  • RNA Substrate Specificity and Structure-Guided Mutational Analysis of T4 RNA Ligase 2.
    Nandakumar J Ho CK Lima CD and Shuman S.
    J. Biol. Chem./279/p.31337-31347, 2003-01
  • Mutation Analysis of Bacteriophage T4 RNA Ligase 1: Differential Functional Group are Required for the Nucleotidyl Transfer and Phosphodiester Bond Formation Steps of the Ligation Reaction.
    Wang LK Ho CK Pei Y and Shuman S.
    J. Biol. Chem./278/p.17601-17608, 2003-01
  • Tat Stimulates Cotranscriptional Capping of HIV-1 mRNA.
    Chiu YL; Ho CK; Saha N; Schwer B; Shuman S; and Rana TM.;...
    Molecular Cell/10/p.585-597, 2002-01
  • Bacteriophage T4 RNA Ligase 2 (gp 24.1) Exemplifies a Family of RNA Ligases Found in All Phylogenic Domains.
    Ho CK and Shuman S.
    Proc. Natl. Acad. Sci. USA/99/p.12709-12714, 2002-01
  • HIV-1 Tat Protein Interacts with Mammalian Capping Enzyme and Stimulates Capping of TAR RNA
    Chiu YL; Coronel E; Ho Kiong; Shuman S; Rana TM
    Journal of Biological Chemistry/276/pp.12959-12966, 2001-04
  • A Yeast-like mRNA Capping Apparatus in Plasmodium falciparum
    Ho CK; Shuman S
    Proc. Natl. Acad. Sci. USA/98(6)/pp.3050-3055, 2001-03
  • RNA Triphosphatase Component of the mRNA Capping Apparatus of Paramecium bursaria Chlorella Virus
    Ho CK; Gong C; Shuman S
    JOURNAL OF VIROLOGY/75/pp.1744-1750, 2001-02
more...
著書
会議発表等
  • Regulation of Protozoa Gene Expression by mRNA Recapping Pathway
    Ho Kiong
    The 2nd Joint Young Researcher Meeting in Biomedical Sciences/2020-01-10--2020-01-11
  • トリパノソーマRNA triphosphataseの結晶構造解析による三リン酸ならびに核酸認識機構の解明
    Ho Kiong; Takagi Yuko; Kuwabara Naoyuki; Truong Dang; Fur...
    第42回日本分子生物学会/2019-12-03--2019-12-06
  • Involving high school students in medical science exchange programs: Experiences from the University of Tsukuba
    Mayers Thomas David; Ho Kiong; Fukuda Aya; Watanabe Yukih...
    第22回日本医学英語教育学会学術集会/2019-08-03--2019-08-04
  • Involving high school students in medical science exchange programs: Experiences from the University of Tsukuba
    Mayers Thomas David; Ho Kiong; Fukuda Aya; Watanabe Yukih...
    第22回日本医学英語教育学会学術集会/2019-08-03--2019-08-04
  • Targeting of mRNA Cap Formation for Treatment of Parasitic Infections
    Ho Kiong
    The Joint Symposium in Infectious Diseases/2019-02-22--2019-02-22
  • Structural and Functional Analysis of protozoan mRNA capping enzyme
    HO KIONG
    第20回日本RNA学会年会/2018-07-09--2018-07-12
  • The messenger RNA recapping pathway in Trypanosome
    Ho Kiong
    第88回日本寄生虫学会大会/2019-03-14--2019-03-16
  • Structural and Functional Analysis of Trypanosoma RNA Triphosphatase
    HO KIONG
    第88回日本寄生虫学会大会/2019-03-14--2019-03-16
  • RNA methylation at the 5’-end of the mRNA stimulates Trypanosoma mRNA recapping activities
    Ho Kiong
    Cold Spring Harbor Meeting, Translational Control Meeting/2018-09-04--2018-09-08
  • Structure and mechanism of archaeal ATP-dependent RNA ligase
    Ho Kiong; Yoshinari Shigeo; Murakami Katsuhiko S.
    Cutting Edge Developments in RNA Biology for the Control of Gene Expression/2017-11-13--2017-11-17
  • Messenger RNA recapping enzyme is regulated by hypermethylation at the 5’-end of the RNA
    Ho Kiong; Ignatochkina Anna V.; Iguchi Jesavel; Kore Anil...
    Cutting Edge Developments in RNA Biology for the Control of Gene Expression/2017-11-13--2017-11-17
  • Molecular Mechanism of mRNA Recapping in Trypanosome
    HO KIONG
    2017年度生命科学系学会合同年次大会/2017-12-06--2017-12-09
  • Identification and characterization of a novel 5'-monophosphate RNA kinase in Trypanosoma brucei
    Ho Kiong
    21th Annual RNA Society Meeting/2016-06-28--2016-07-02
  • Recapping the Message: The mRNA Decapping and Recapping Pathway in Trypanosomes
    Ho Kiong
    21th Annual RNA Society International Meeting/2016-06-28--2016-07-02
  • Inhibitor Screening Against Trypanosoma cruzi RNA Triphosphatase
    Ho Kiong; Takagi Yuko; Kuwabara Naoyuki; Tani Osamu; Saka...
    Kinetoplastid Molecular Cell Biology 2017/2017-04-22--2017-04-26
  • Archaea RNA Ligase is Required for Circularizing Small Non-Coding RNA.
    Ho Kiong; Liu Yancheng; Takagi Yuko; Hirata Akira; Hori H...
    第１９回日本RNA学会/2017-07-19--2017-07-21
  • Trypanaosome mRNA recapping activity is modulated by hypermethylation derived from cap 4 structure
    Ho Kiong; Ignatochkina Anna V.; Iguchi Jesavel; Kore Anil...
    第１９回日本RNA学会/2017-07-19--2017-07-21
担当授業科目
2020-10 -- 2021-02国際実践医科学研究特論II筑波大学
2020-04 -- 2020-08国際実践医科学研究特論II筑波大学
2020-10 -- 2021-02国際実践医科学研究特論III筑波大学
2020-04 -- 2020-08国際実践医科学研究特論III筑波大学
2020-10 -- 2021-02インターンシップII筑波大学
2020-04 -- 2020-08インターンシップII筑波大学
2020-10 -- 2020-10医科学グループワーク演習筑波大学
2020-10 -- 2021-02国際実践医科学研究特論I筑波大学
2020-04 -- 2020-08国際実践医科学研究特論I筑波大学
2020-04 -- 2020-08基礎医科学演習筑波大学
more...
授業以外の教育活動
2020-01 -- 2020-01Transcriptosome Analysis, Experimental Course in Biotechnology and MedicineUniversity of Indonesia Medical Campus
2020-01 -- 2020-01University of Medicine and Pharmacy, VietnamUniversity of Medicine and Pharmacy, Vietnam
2020-02 -- 2020-02Undergraduate Medical Science Course in Tsukuba筑波大学
2020-01 -- 2020-01Biomedical Research Workshop in South East AsiaUniversity of Indonesia Medical Campus
2019-08 -- 2019-08感染生物ワークショップHCM Biotechnology Center
2019-08 -- 2019-08International Medical Science Training Course in HCMCUniversity of Medicine and Pharmacy HCMC
2019-02 -- 2019-02Gene Editing Workshop, Experimental Course in Biotechnology and MedicineHCM Biotechnology Center
2019-02 -- 2019-02Transcriptosome Analysis, Experimental Course in Biotechnology and MedicineUniversity of Medicine and Pharmacy HCMC
2018-08 -- 2018-08感染生物ワークショップHCM Biotechnology Center
2018-08 -- 2018-08International Medical Science Training Course in HCMCUniversity of Medicine and Pharmacy HCMC
more...
一般講演
  • Structure and Mechanism of RNA Repair Enzymes
    Ho Kiong
    生命と機能とかたち/2018-03-07--2018-03-07
学内管理運営業績
2018-04 -- (現在)全学学群教育課程委員会委員
2018-04 -- (現在)全学国際戦略委員会委員
2018-04 -- (現在)医学医療系　国際連携委員会副委員長
2014-04 -- (現在)医学生命システム　国際連携委員会委員
2016-04 -- (現在)医学フロンティア 国際連携委員会委員
2018-04 -- (現在)医療科学類　G30英語プログラム委員長
2016-04 -- (現在)医療科学類　国際連携委員会委員
2018-04 -- (現在)医療科学類　情報／広告委員会委員
2018-04 -- (現在)医療科学類　カリキュラム委員会委員
2019-04 -- (現在)ヒューマンバイオロジープログラム 学位審査委員会委員長
more...

(最終更新日: 2020-08-18)