WATANABE Yukihide
- Affiliation
- Institute of Medicine
- Official title
- Assistant Professor
- URL
- G2D0x-x'xy|<KG&{E-,.$.yxExzE#)
- Office
- Experimental Pathology
- Research projects
新規がん遺伝子Xを標的としたがん幹細胞誘導を阻害する薬剤の探索 2023-04 -- 2024-03 Yukihide Watanabe The Japan Agency for Medical Research and Development (AMED)/AMED 創薬総合支援事業 14,993,000Yen 課題名「がん幹細胞性誘導を制 御する PMEPA1/TMEPAI を標 的とした抗腫瘍薬の開発 2022-04 -- 2023-03 Yukihide Watanabe The Japan Agency for Medical Research and Development (AMED)/橋渡し研究プログラム 補助事業シーズ A 1,800,000Yen がん幹細胞性誘導を制 御する PMEPA1/TMEPAI を標 的とした抗腫瘍薬の開発 2021-04 -- 2022-03 Yukihide Watanabe The Japan Agency for Medical Research and Development (AMED)/橋渡し研究戦略的推進プログ ラム補助事業シーズ A 1,800,000Yen がん細胞の持続的増殖における幹細胞性誘導メカニズムの解明 2021 -- 2023 渡邊 幸秀 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C) 4,290,000Yen TMEPAIに対する特殊環状ペプチドを用いたがん治療法、診断法の開発 2018 -- 2020 渡邊 幸秀 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C) 4,420,000Yen 腫瘍形成におけるTMEPAIの分子機構の解明 2016 -- 2017 渡邊 幸秀 Japan Society for the Promotion of Science/Grant-in-Aid for Young Scientists(B) 4,030,000Yen 特殊環状ペプチドを用いた抗腫瘍薬の開発 2016-03 -- 2016-12 渡邊幸秀 上原記念生命科学財団 研究奨励金/ 2,000,000Yen 腫瘍形成におけるTMEPAIの分子機構の解明 2016-04 -- 2018-03 渡邊幸秀 MEXT/科学研究費 若手B TMEPAIの腫瘍の発生・悪性化における役割と臨床への応用 2013 -- 2014 渡邊 幸秀 Japan Society for the Promotion of Science/若手研究(B) 4,290,000Yen - Career history
2010-06 -- 2011-05 University of Tsukuba人間総合科学研究科博士研究員 2010-04 -- 2010-06 University of Tsukuba大学院人間総合科学研究科博士特別研究員 2008-04 -- 2010-03 日本学術振興会特別研究員(DC2) - Degree
2010-03 Ph.D University of Tsukuba - Articles
- Design of Specific and Efficient sgRNA for CRISPR/Cas9 System to Knockout Superoxide Dismutase 2 in Breast Cancer Stem Cells
Arumsari Sekar; Wanandi Septelia Inawati; Syahrani Res...
INTERNATIONAL JOURNAL OF TECHNOLOGY/15(2)/pp.353-363, 2024-02-05 - PMEPA1 mutation found in 3 Japanese families with systemic connective tissue disorders
Morisaki Hiroko; Yamanaka Itaru; Ohata Takako; Kosho ...
EUROPEAN JOURNAL OF HUMAN GENETICS/32(1)/pp.422-422, 2024-01 - Suppression of intestinal tumorigenicity by loss of TMEPAI family genes
Uchida Yoshimi; Nakano Naoko; Itoh Fumiko; Watanabe Y...
CANCER SCIENCE/114(1:SI)/pp.2056-2056, 2023-02 - Promotion of squamous cell carcinoma tumorigenesis by oncogene-mediated THG-1/TSC22D4 phosphorylation
Goto Nohara; Suzuki Hiroyuki; Zheng Ling; Okano Yasuh...
CANCER SCIENCE/114(10)/pp.3972-3983, 2023-10 - The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition
Tzavlaki Kalliopi; Ohata Yae; Morén Anita; Watanabe Y...
JOURNAL OF CELLULAR PHYSIOLOGY/238(4)/pp.790-812, 2023-04-01 - Role of TMEPAI family in intestinal tumorigenesis
Nakano Naoko; Itoh Fumiko; Watanabe Yukihide; Taketo ...
CANCER SCIENCE/113(1:SI)/pp.332-332, 2022-02 - Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase
P Lönn; M Vanlandewijck; Erna Raja; M Kowanetz; Y Watana...
Journal of Biological Chemistry, 2012-04 - Advanced Topics in Biotechnology and Medicine: An intensive literature-based course to encourage critical thinking in science and build academic English skills.
Ho Kiong; Mayers Thomas David; Morikawa Kazuya; Watanabe ...
Journal of Medical English Education./20(1)/pp.39-46, 2021-10 - TGF-beta-Induced TMEPAI Promotes Epithelial- Mesenchymal Transition in Doxorubicin-Treated Triple-Negative Breast Cancer Cells via SMAD3 and PI3K/AKT Pathway Alteration
Wardhani Bantari W. K.; Louisa Melva; Watanabe Yukihid...
BREAST CANCER-TARGETS AND THERAPY/13/pp.529-538, 2021 - Advanced Topics in Biotechnology and Medicine: An intensive literature-based course to encourage critical thinking in science and build academic English skills
Ho C. Kiong; Mayers Thomas David; Morikawa Kazuya; Watana...
Journal of Medical English Education/20(3)/pp.39-46, 2021-10 - PMEPA1/TMEPAI Is a Unique Tumorigenic Activator of AKT Promoting Proteasomal Degradation of PHLPP1 in Triple-Negative Breast Cancer Cells
Haque Md Anwarul; Abdelaziz Mohammed; Puteri Meidi Uta...
Cancers/13(19), 2021-09-30 - PMEPA1/TMEPAI promotes tumorigenesis in triple negative breast cancer by sustaining PI3K/AKT signaling
Haque Md Anwarul; Watanabe Yukihide; Kato Mitsuyasu
CANCER SCIENCE/112(1:SI)/pp.266-266, 2021-02 - Involving high school students in medical science exchange programs: Experiences from the University of Tsukuba
Mayers Thomas; Morikawa Kazuya; Fukuda Aya; Watanabe Yuk...
J Med Eng Educ/19(1)/pp.40-44, 2020-02 - TGF-β-Induced TMEPAI Attenuates the Response of Triple-Negative Breast Cancer Cells to Doxorubicin and Paclitaxel
BW Wardhani; MU Puteri; Watanabe Yukihide; M Louisa; R S...
J Exp Pharmacol./12/pp.17-26, 2020-01 - PMEPA1/TMEPAI isoforms function via its PY and Smad interaction motifs for tumorigenic activities of breast cancer cells
Puteri Meidi U; Watanabe Yukihide; Wardhani Bantari W K; ...
Genes to cells/25(6)/pp.375-390, 2020-06 - Decreased sensitivity of several anticancer drugs in TMEPAI knockout triple-negative breast cancer cells
Wardhani Bantari Wisynu Kusuma; Puteri Meidi Utami; Wat...
MEDICAL JOURNAL OF INDONESIA/28(2)/pp.110-115, 2019-06 - TMEPAI/PMEPA1 inhibits Wnt signaling by regulating β-catenin stability and nuclear accumulation in triple negative breast cancer cells
Amalia Riezki; Abdelaziz Mohammed; Puteri Meidi Utami; Hw...
Cellular signalling/59/pp.24-33, 2019-07 - PMEPA1/TMEPAI knockout impairs tumor growth and lung metastasis in MDA-MB-231 cells without changing monolayer culture cell growth
Abdelaziz Mohammed; Watanabe Yukihide; Kato Mitsuyasu
Journal of biochemistry/165(5)/pp.411-414, 2019-05 - Glycoprotein nmb is exposed on the surface of dormant breast cancer cells and induces stem cell-like properties
Chen Chen; Okita Yukari; Watanabe Yukihide; Abe Fumie; Fi...
Cancer Research/78(22)/pp.6424-6435, 2018-09 - Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells
Caja Laia; Tzavlaki Kalliopi; Dadras Mahsa S; Tan E-J...
Oncogene/37(19)/pp.2515-2531, 2018-02 - Knock-out transmembrane prostate androgen-induced protein gene suppressed triple-negative breast cancer cell proliferation
Wardhani Bantari W. K.; Puteri Meidi U.; Watanabe Yuki...
MEDICAL JOURNAL OF INDONESIA/26(3)/pp.178-182, 2017-09 - Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation.
Watanabe Yukihide; Papoutsoglou Panagiotis; Maturi Varun...
J Biol Chem./291(24)/pp.12706-12723, 2016-06 - The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling.
Raja Erna; Tzavlaki Kalliopi; Vuilleumier Robin; Edlund ...
Oncotarget/7(2)/pp.1120-1143, 2016-01 - Cooperative induction of transmembrane prostate androgen induced protein TMEPAI/PMEPA1 by transforming growth factor-b and epidermal growth factor signaling.
Azami S; Vo Nguyen TT; Watanabe Yukihide; Kato M
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS/456(2)/pp.580-585, 2015-01 - Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling.
Dahl M; Maturi V; Lönn P; Papoutsoglou P; Zieba A; Vanlandewij...
PLoS One/9, 2014-08 - more...
- Design of Specific and Efficient sgRNA for CRISPR/Cas9 System to Knockout Superoxide Dismutase 2 in Breast Cancer Stem Cells
- Books
- TGF-β 解説編、TGF-β 診断編
渡邊 幸秀
病理診断に役立つ分子生物学/文光堂/pp.432-439, 2011-01 - がんの増殖・進展とTGF-b
渡邊 幸秀
慢性炎症とがん/北隆館/pp.54-59, 2016-02
- TGF-β 解説編、TGF-β 診断編
- Conference, etc.
- トリプルネガティブ乳癌における非転移性メラノーマタンパク質 B に よる腫瘍免疫制御機構
川西 邦夫; Thuylinh Dangcao; 沖田 結花里; 渡邊 幸秀; 橋本 幸枝; Kowit...
第83回日本癌学会学術総会/2024/9/19--2024/9/21 - 空間的トランスクリプトーム解析を用いたトリプルネガティブ乳癌に 対する治療標的分子の探索
白谷 理恵; 川西 邦夫; Kowit Hengphasatporn; 沖田 結花里; 渡邊 幸秀; 重...
第83回日本癌学会学術総会/2024/9/19--2024/9/21 - PMEPA1 mutation found in 3 Japanese families with systemic connective tissue disorders
Morisaki Hiroko; Yamanaka Itaru; Ohata Takako; Kosho ...
56th Annual Conference of the European-Society-of-Human-Genetics (ESHG)/2023-06-10--2023-06-13 - 多分野融合によるアミロイド類縁腎臓疾患のメカニズム解析
川西邦夫; 渡邊幸秀; 康徳東; 堂本裕加子; Kowit Hengphasatporn; 広瀬雄二郎; 徳楽清...
第40回分子病理学研究会クラークシンポジウム/2023-07-14--2023-07-15 - Experimental models development for drug mechanism study using genome editing
Watanabe Yukihide
Indonesia National Defense University, international symposium ~Latest trend in pharmacological research~/2023-02-16--2023-02-16 - Cancer-Specific Sialylation Of Glycoprotein Nonmetastatic Melanoma Protein B Interact With Tumor-Associated Macrophage in Triple-Negative Breast Carcinoma via Siglec-9
Dang Cao Thuy Linh Linda; Kunio Kawanishi; Yukari Okit...
the 26th International Glycoconjugate Symposium (IGS)/2023-08-27--2023-9-1 - Magnitude of DNAJB9 in Fibrillary glomerulonephritis
川西 邦夫; 康 徳東; 渡邊 幸秀; 広川 貴次; 加藤 光保; 遠藤 知美; 鈴木 智; 小川 弥生; 清水 章
The 111th Annual Meeting of the Japanese Society of Pathology/2022/04/14--2022/04/16 - TMEPAI functions via its PY and a Smad Interaction motif (SIM) for tumorigenic activities of breast cancer cells
Puteri Meidi Utami; Wardhani Bantari W.K.; Amalia Riezki...
The 1st International Conference on Pharmaceutical Sciences and Military Pharmacy/2021-09-03--2021-09-04 - 高輝度化学発光タンパク質Nano-lanternを用いたがん幹細胞の可視化と動態解析
小原美里; 加藤光保; 渡邊幸秀
第79回日本癌学会学術総会/2020-10-01--2020-10-03 - PMEPAI/TMEPAI promotes tumorigenesis in triple negative breast cancer by sustaining PI3K/AKT signaling
Md Anwarul Haque; Watanabe Yukihide; Kato Mitsuyasu
第79回日本癌学会学術総会/2020-10-01--2020-10-03 - 幹細胞性誘導によるがん細胞の持続的増殖機構
加藤光保; 渡邊幸秀; 沖田 結花里; Utami Pteri Meidi; Abdelaziz Mohammed; ...
第108回日本病理学会総会/2019-05-09--2019-05-11 - 高輝度化学発光タンパク質Nano-lanternを用いたがん幹細胞の可視化と動態解析
小原 美里; 加藤 光保; 渡邊 幸秀
第109回日本病理学会総会/2020-07-01--2020-07-31 - TMEPAI promotes stemness of breast cancer cells by regulating AKT signaling
Watanabe Yukihide
The TGF-beta meeting in Leiden/2019-08-22--2019-08-24 - Involving high school students in medical science exchange programs: Experiences from the University of Tsukuba
Mayers Thomas David; Ho Kiong; Fukuda Aya; Watanabe Yuki...
The 22nd JASMEE Academic Meeting/2019-08-03--2019-08-04 - Involving high school students in medical science exchange programs: Experiences from the University of Tsukuba
Mayers Thomas David; Ho Kiong; Fukuda Aya; Watanabe Yuki...
The 22nd JASMEE Academic Meeting/2019-08-03--2019-08-04 - 幹細胞性誘導によるがん細胞の持続的増殖機構
加藤 光保; 渡邊 幸秀; 沖田 結花里; Meidi Utami Puteri; Mohammed Abdel...
第38回分子病理研究会/2019-07-19--2019-07-20 - TMEPAI drives anchorage-independent growth in breast cancer cells through its SIM and PY motifs
Watanabe Yukihide; Puteri Meidi U.; Amalia Riezki; Abdela...
11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research/2019-02-08--2019-02-12 - The roles of TMEPAI in breast cancer cells
Puteri Meidi Utami; Wardhani Bantari Wisynu Kusuma; Amali...
第41回日本分子生物学会年会/2018-11-28--2018-11-30 - TMEPAI is involved in tumorigenesis through regulating stem cell frequency in breast cancer cell
渡邊幸秀; Meidi Utami Puteri; 加藤 光保
第2回がん三次元培養研究会/2018-11-27--2018-11-27 - The roles of TMEPAI in breast cancer cells
Puteri Meidi Utami; Wardhani Bantari Wisynu Kusuma; Amali...
The 3rd International Conference on Advance Pharmacy and Pharmaceutical Sciences(ICAPPS 2018)/2018-09-26--2018-09-29 - Identification and analysis of slow-proliferating cells in colon cancer cell line
Oishi Makoto; Watanabe Yukihide; Kato Mitsuyasu
Tsukuba Global Science Week 2018/2018-09-20--2018-09-22 - Roles of TMEPAI in breast cancer cells
Watanabe Yukihide
The 17th TGF-b meeting/2017-08-31--2017-09-02
- トリプルネガティブ乳癌における非転移性メラノーマタンパク質 B に よる腫瘍免疫制御機構
- Teaching
2024-10 -- 2024-12 Human Pathology and Oncology University of Tsukuba. 2024-10 -- 2025-02 Practice in Diagnostic Pathology I University of Tsukuba. 2024-04 -- 2024-08 Practice in Diagnostic Pathology I University of Tsukuba. 2024-10 -- 2025-02 Practice in Diagnostic Pathology II University of Tsukuba. 2024-04 -- 2024-08 Practice in Diagnostic Pathology II University of Tsukuba. 2024-04 -- 2024-08 Medical Science Seminar V: Career Path University of Tsukuba. 2024-10 -- 2025-02 Medical Science Seminar V: Career Path University of Tsukuba. 2024-10 -- 2025-02 Topics in Cutting-edge Medicine I University of Tsukuba. 2024-04 -- 2024-08 Topics in Cutting-edge Medicine I University of Tsukuba. 2024-10 -- 2024-12 Oncology University of Tsukuba. more... - Other educational activities
2018-02 -- 2018-02 Biomedical Research Partnership Workshop 2018 University of Indonesia 2018-07 -- 2018-08 Summer Research Program in Tsukuba 2018 University of Tsukuba 2017-07 -- 2017-07 Summer Research Program in Tsukuba 2017 University of Tsukuba 2016-01 -- 2016-01 Molecular Biology Course in Ho Chi Minh City Instutute of Tropical Biology 2015-01 -- 2015-01 Molecular Biology Course in Ho Chi Minh City Institute of Tropical Biology 2014-03 -- 2014-03 Molecular Biology Course in Ho Chi Minh City Instutute of Tropical Biology - University Management
2013-10 -- 2018-03 生命システム医学専攻キャリア支援 担当教員 2017-04 -- 2023-03 生命システム医学専攻国際化推進委員会・フロンティア医科学専攻教育国際連携委員会 委員 - Other activities
2011-08 -- 2013-08 頭脳循環を活性化する若手研究者海外派遣事業 派遣先:スウェーデンウプサラ大学(ルードヴィッグ癌研究所)
(Last updated: 2024-08-19)