Yanagisawa Hiromi
- Affiliation
- Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA)
- Official title
- Professor
- ORCID
- 0000-0002-7576-9186
- KAKEN ID
- 40746301
- URL
- )?BP8E8>@J8N8Zgg8KZggK8I8cKJLBL98c8:cAG
- Office
- Extracellular environment and cellular responses in development and disease
- Phone
- 029-853-7318
- Research fields
Cardiovascular medicine General medical chemistry Cardiovascular surgery Pathological medical chemistry - Research keywords
extracellular microenvironment extracellular matrix aortic dissection vascular injury and vascular remodeling heritable thoracic aortic disease (HTAD) vascular biology mechanobiology elastic fibers biomechanics Raman Imaging more... - Research projects
新規大動脈解離マウスモデルを用いたマルファン症候群等類縁疾患の大動脈解離発症機序の解明 2022-04 -- 2023-03 Hiromi Yanagisawa Japan Agency for Medical Research and Development (AMED)/AMED難治性疾患実用化研究事業 11,830,000Yen ミクロフィブリル変異による大動脈解離の病態解明 2021-10 -- 2025-03 Hiromi Yanagisawa Japan Society of for the Promotion of Science/国際共同研究加速基金(国際共同研究強化(B)) 19,110,000Yen 新規大動脈解離マウスモデルを用いたマルファン症候群等類縁疾患の大動脈解離発症機序の解明 2021-04 -- 2022-03 Yanagisawa, Hiromi The Japan Agency for Medical Research and Development (AMED)/AMED難治性疾患実用化研究事業 15,860,000Yen メカノトランスダクションを基軸とした大動脈瘤発症機序の解明と破裂予測の基盤研究 2020-04 -- 2023-03 Hiromi Yanagisawa JSPS/Grant-in-Aid for Scientific Research (B) 17,810,000Yen 上皮幹細胞コンパートメントを規定する分子機構と生物学的意義の解明 2020-04 -- 2024-03 佐田亜衣子 独立行政法人 日本学術振興会/Grant-in-Aid for Scientific Research (B) 1,600,000Yen 表皮幹細胞の接着と増殖を担うFibulin-7の生化学特性の解明 2020-02 -- 2022-01 柳沢裕美 財団法人東京生化学研究会/研究助成 4,000,000Yen ラマン分光イメージング法を用いた切迫大動脈瘤の時間的空間解析と破裂予測 2019-12 -- 2020-11 柳沢裕美 財団法人 先進医薬研究振興財団/ 1,000,000Yen メカニカルストレス応答の破綻に着目した大動脈瘤形成メカニズムの解明 2017-04 -- 2020-03 柳沢 裕美 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B) 17,290,000Yen Role of fibulin-7, a new member of fibulin ECM proteins, in development and disease 2012-01 -- 2015-08 Hiromi Yanagisawa American Heart Association/Established Investigator Award Loss of extracellular matrix regulation and development of aortic aneurysms 2010-12 -- 2015-08 Hiromi Yanagisawa National Institute of Health (NIH)/R01 more... - Career history
2015-09 -- (current) University of TsukubaTARA CenterProfessor 2014-09 -- 2015-08 University of TsukubaTARA CenterProfessor 1998-01 -- 2015-08 University of Texas Southwestern Medical CenterDepartment of Molecular Biologyインストラクター 助教授 准教授(テニュア) 1991-10 -- 1997-12 University of Texas Southwestern Medical CenterDepartment of Biochemistryポスドク研究員 1986-06 -- 1988-03 University of Tsukuba HospitalInternal Medicineレジデント - Academic background
1980 -- 1986 University of Tsukuba School of Medicine - Degree
1993-03 Ph.D. University of Tsukuba - Licenses and qualifications
1986 医師免許証 - Academic societies
2022 -- (current) European Society of Cardiology 2022-01 -- (current) International Society for Matrix Biology 2021-07 -- (current) THE JAPANESE SOCIETY FOR CARDIOVASCULAR SURGERY 2019 -- (current) The Molecular Biology Society of Japan 2019 -- (current) The Japanese Biochemical Society 2018 -- 2022 JAPAN PEDIATRIC SOCIETY 2016 -- 2022 老化促進モデルマウス(SAM)学会 2016 -- (current) 日本循環器学会 2015 -- (current) 日本心血管内分泌代謝学会 2015 -- (current) 日本血管生物医学会 more... - Honors & Awards
2016 Mizutani Foundation for Glycoscience 2015 内藤記念科学財団研究助成 2015 上原記念生命科学財団研究助成 2012 Established Investigator Award (AHA) 2008 Junior Investigator Award (ASMB) - Articles
- Protective Role of Endothelial Fibulin-4 in Valvulo-Arterial Integrity
Nguyen Tram Anh Vu; Lino Caroline Antunes; Hang Huynh Th...
Journal of the American Heart Association/12(1), 2023-01-03 - Partial endothelial-to-mesenchymal transition mediated by HIF-induced CD45 in neointima formation upon carotid artery ligation
Yamashiro Yoshito; Ramirez Karina; Nagayama Kazuaki; Hatt...
Cardiovascular research, 2022-12-20 - Fibulin7 aggravates calcium oxalate-induced acute kidney injury by binding to calcium oxalate crystals
Sugiura Hidekazu; Tsunezumi Jun; Yanagisawa Hiromi; Futay...
Journal of cellular physiology, 2022-11-12 - TBX1 targets the miR-200-ZEB2 axis to induce epithelial differentiation and inhibit stem cell properties
Funato Noriko; Yanagisawa Hiromi
Scientific reports/12(1), 2022-11-23 - Editorial: Extracellular matrix dynamics in biology, bioengineering, and pathology, volume II
Loganathan Rajprasad; Yanagisawa Hiromi; Gentleman Eil...
Frontiers in cell and developmental biology/10, 2022-04-01 - The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging
Erna Raja; Changarathil Gopakumar; Oinam Lalhaba; Tsunezu...
EMBO REPORTS, 2022-10 - The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging
RAJA ERNA; Changarathil Gopakumar; Oinam Lalhaba; Ngo Ye...
bioRxiv, 2022-03 - Embracing Diversity, Equity, and Inclusion in the Scientific Community-Viewpoints of the Diversity, Equity, and Inclusion Committee of the North American Vascular Biology Organization
Garelnabi Mahdi; Cowdin Mitzy; Fang Yun; Shrestha Ban...
FRONTIERS IN CARDIOVASCULAR MEDICINE/9, 2022-04-01 - Experimental and Mouse-Specific Computational Models of the Fbln4 Mouse to Identify Potential Biomarkers for Ascending Thoracic Aortic Aneurysm
Bazzi Marisa S; Balouchzadeh Ramin; Pavey Shawn N; Qui...
Cardiovascular engineering and technology/Epub, 2022-01-22 - Isolation and Culture of Primary Oral Keratinocytes from the Adult Mouse Palate
Ngo Yen Xuan; Haga Kenta; Suzuki Ayako; Kato Hiroko; Yana...
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS/(175), 2021-09 - Extracellular matrix-mediated remodeling and mechanotransduction in large vessels during development and disease
Yanagisawa Hiromi; Yokoyama Utako
Cellular Signaling/86, 2021-08 - Raman microspectroscopy and Raman imaging reveal biomarkers specific for thoracic aortic aneurysms
Sugiyama Kaori; Marzi Julia; Alber Julia; Brauchle Eva M...
Cell Reports Medicine/2(5), 2021-05 - Contribution of PDGFRα-positive cells in maintenance and injury responses in mouse large vessels
Kimura Kenichi; Ramirez Karina; Nguyen Tram Anh Vu; Yamas...
Scientific Reports/11, 2021-04 - Defining compartmentalized stem cell populations with distinct cell division dynamics in the ocular surface epithelium
Ishii Ryutaro; Yanagisawa Hiromi; Sada Aiko
Development (Cambridge, England)/147(24), 2020-12 - Dysregulated assembly of elastic fibers in fibulin-5 knockout mice results in a tendon-specific increase in elastic modulus
Eekhoff Jeremy D; Steenbock Heiko; Berke Ian M; Brinck...
Journal of the mechanical behavior of biomedical materials/113, 2020-10 - The molecular mechanism of mechanotransduction in vascular homeostasis and disease
Yamashiro Yoshito; Yanagisawa Hiromi
Clinical science (London, England : 1979)/134(17)/pp.2399-2418, 2020-09 - Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging
Oinam Lalhaba; Changarathil Gopakumar; Raja Erna; Ngo Ye...
Aging cell/19(8), 2020-07 - TBX1 Regulates Chondrocyte Maturation in the Spheno-occipital Synchondrosis
Funato N.; Srivastava D.; Shibata S.; Yanagisawa H.
JOURNAL OF DENTAL RESEARCH/99(10)/pp.1182-1191, 2020-05 - Role of PAR1-Egr1 in the Initiation of Thoracic Aortic Aneurysm in Fbln4-Deficient Mice
Shin Seung Jae; Hang Huynh Thuy; Thang Bui Quoc; Shimoda ...
Arteriosclerosis, thrombosis, and vascular biology/40(8)/pp.1905-1917, 2020-06 - Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP in the vascular remodeling
Yamashiro Yoshito; Thang Bui Quoc; Ramirez Karina; Shin ...
Proceedings of the National Academy of Sciences of the United States of America/117(18)/pp.9896-9905, 2020-04 - Fibulin-4 exerts a dual role in LTBP-4L-mediated matrix assembly and function.
Kumra Heena; Neler Valenin; Hakami Hana; Pagliuzza Ameli...
Proceedings of the National Academy of Sciences of the United States of America/116(41)/pp.20428-20437, 2019-10 - Novel ELN mutation in a Japanese family with a severe form of supravalvular aortic stenosis
Sugiyama Kaori; Horigome Hitoshi; Lin Lisheng; Murakami ...
MOLECULAR GENETICS & GENOMIC MEDICINE/7(11), 2019-09 - Recent updates on the molecular network of elastic fiber formation
Shin Seung Jae; Yanagisawa Hiromi
Essays in biochemistry/63(12)/pp.365-376, 2019-08 - Matrix Aging in the Vessel Wall
柳沢 裕美; 中邨智之
Journal of Japanese Society for Biomaterials/38(3)/pp.172-177, 2020-07 - A Case of Noonan Syndrome with the SHOC2 Mutation Complicated by Dilation of a Single Left Coronary Artery
石川 伸行; 堀米 仁志; 村上 卓; 高橋 実穂; 野崎 良寛; 林 立申; 塩野 淳子; 平松 祐司; 柳沢 裕美
Pediatric Cardiology and Cardiac Surgery/35(2)/pp.127-131, 2019-05 - more...
- Protective Role of Endothelial Fibulin-4 in Valvulo-Arterial Integrity
- Books
- 大動脈瘤への分子生物学的アプローチ
木村 健一; 柳沢裕美
心臓/日本医学出版, 2022-06 - Epidermal stem cell lineages
Oinam L; Changarathil G; Ngo YX; Yanagisawa H; *Sada A
Advances in Stem Cells and their Niches, 2019-04
- 大動脈瘤への分子生物学的アプローチ
- Conference, etc.
- A Novel mouse model of aortic dissection caused by a point mutation in the hybrid domain of the fibrillin-1 gene
Kimura Kenichi; Motoyama Eri; Ishii Ryutaro; Yamashiro Y...
The 6th JCS Council Forum on Basic CardioVascular Research/2022-12-16--2022-12-17 - Fate mapping analysis of developmental mechanism in bone marrow niche
木村 健一; 石井 柳太郎; 渡辺 純菜; Bernd Fleischmann; 柳沢 裕美
第45回日本分子生物学会年会/2022-11-30--2022-12-02 - Dynamics of CD73 during retinal development
石井 柳太郎; 木村健一; 柳沢裕美
第45回日本分子生物学会年会/2022-11-30--2022-12-02 - A Novel mouse model of aortic dissection caused by a point mutation in the hybrid domain of the fibrillin-1 gene
Kimura Kenichi; Motoyama Eri; Ishii Ryutaro; Sugiyama Ka...
11th International Symposium on Marfan, Loeys-Dietz, and Related Conditions/2022-08-29--2022-09-01 - Dynamics of CD73 during retinal development
石井 柳太郎; 木村健一; 柳沢裕美
第8回 MatriCell フォーラム/2022-09-10--2022-09-11 - 血管壁細胞の挙動と制御因子の解明
柳沢 裕美
第20回日本再生医療学会総会/2022-03-19 - ラマン分光法を用いた大動脈瘤の新規イメージングと スペクトル解析
柳沢 裕美
日本動脈硬化学会/2021-10-23--2021-10-24 - 新規Fbn1 遺伝子変異マウスを用いたマルファン症候群の大動脈解離発症機序の解明
本山絵理; 木村健一; 石井柳太郎; 杉山夏緒里; 山城義人; 神吉佐智子; 柳沢 裕美
エラスチン・関連分子研究会学術集会/2021-12-18--2021-12-19 - 細胞外マトリックスに着目した大動脈瘤のラマン分光イメージング法
柳沢 裕美
日本血管生物医学会/2021-12-10--2021-12-11 - Matrix-cell Interactions and aortic diseases
Yanagisawa Hiromi
North American Vascular Biology Organization Vascular Biology 2021/2021-10-26--2021-10-29 - 細胞系譜解析を用いた角結膜幹細胞の動態解明
石井 柳太郎; 木村 健一; 柳沢 裕美; 佐田 亜衣子
第16回和歌山TRP研究会/2021-11-22 - Women Faculty Networking -ダイバーシティーリーダーの育成-
柳沢 裕美
日本神経学会学術大会/2021-05-19--2021-05-23 - Matrix-mediated mechanotransduction In the aortic wall
柳沢 裕美
Materials, Mimics, and Microfluidics:Engineering Tools for Mechanobiology (MBI 3M)/2021-07-21--2021-07-23 - Searching for novel biomarkers of thoracic aortic aneurysms using Raman microspectroscopy
柳沢 裕美
The International Society for Applied Cardiovascular Biology (心血管代謝週間2020)/2021-03-12--2021-03-13 - Matrix-mediated mechanotransduction and aortic disease
柳沢 裕美
日本血管生物医学会学術集会(心血管代謝週間2020)/2021-03-12--2021-03-13 - 細胞系譜解析モデルを用いた骨髄微小環境形成メカニズムの解明
木村 健一; 石井 柳太郎; Bernd K. Fleischmann; 柳沢 裕美
第20回日本再生医療学会総会/2021-03 - Raman Microspectroscopy and Imaging Reveal Novel Biomarkers Specific for Thoracic Aortic Aneurysms
Sugiyama Kaori; Marzi Julia; Brauchle Eva Maria; Ando Ma...
GenTAC Aortic Summit/2020-09-29--2020-10-10 - Defining heterogeneous stem cell populations in oral and eye surface epithelia
Ryutaro Ishii; Yen Xuan Ng; Kenji Izumi; Hiromi Yanagisa...
日本発生生物学会オンライントライアルミーティング/2020-09-24--2020-09-25 - Thrombospondin-1 を介した大動脈瘤血管壁の機械的応答と大動脈瘤形成における役割
山城義人; Thang Bui Quoc; 辛承宰; Caroline Antunes Lino; 中邨智之; Jung...
日本結合組織学会/2020-09-19--2020-09-20 - Cell-specific function of fibulin-4 in progression of ascending aortic aneurysm in mice
Anh Nguyen Vu Tram; Hang Huynh Thuy; Lino Caroline Antun...
International Vascular Biology Meeting/2020-09-09--2020-09-12 - ラマン分光法と多変量解析を用いた胸部大動脈瘤に特異的な分子指紋の同定
杉山夏緒里; Julia Marzi; Eva Maria Brauchle; 安藤正浩; 山城義人; Bhama R...
日本結合組織学会学術大会/2020-09-19--2020-09-20 - Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP signaling pathway in remodeling ofvessel wall
山城義人; 柳沢 裕美
日本循環器学会/2020-07-29--2020-08-01 - Matrix-mediated mechanotransduction and aortic aneurysms
柳沢 裕美
NAVBO Summer Camp/2020-06-29--2020-06-29 - DEFINING STEM CELL DYNAMICS IN THE MOUSE OCULAR SURFACE EPITHELIUM
Ishii Ryutaro; Hiromi Yanagisawa; Aiko Sada
ISSCR 2020 Annual Meeting/2020-06-24--2020-06-27 - Contribution of PDGFRa-positive cell population during vascular remodeling
Ramirez Karina; Kimura Kenichi; Nguyen Tram Anh Vu; Yamas...
Tsukuba Global Science Week 2020/2020-09-28--2020-09-30 - more...
- A Novel mouse model of aortic dissection caused by a point mutation in the hybrid domain of the fibrillin-1 gene
- Teaching
2022-10 -- 2023-02 Basic Experiments in Human Biology University of Tsukuba. 2022-04 -- 2022-08 Special Practice in Human Biology III University of Tsukuba. 2022-10 -- 2023-02 Special Practice in Human Biology III University of Tsukuba. 2022-04 -- 2022-08 Advanced Exercise on Public Health University of Tsukuba. 2022-10 -- 2023-02 Advanced Exercise on Public Health University of Tsukuba. 2022-10 -- 2023-02 Special Seminars in Human Biology II University of Tsukuba. 2022-10 -- 2022-12 Cell Systemology (Cell Biology) University of Tsukuba. 2022-10 -- 2023-02 Special Lectures in Human Biology II University of Tsukuba. 2022-10 -- 2023-02 Special Research in Human Biology II University of Tsukuba. 2022-10 -- 2023-02 Practice in Human Medical Biology II University of Tsukuba. more... - Other educational activities
2021-05 -- 2021-05 世界のトップサイエンティストの男女共同参画 第62回日本神経学会 2020-12 -- 2020-12 「イノベーションを支える多様な人材の活躍に向 けて~次期科学技術・イノベーション基本計画の共創に向けた全国キャラバン(つく ば開催)~」 つくば女性研究者協議会・内閣府・つくば市 2020-03 -- 2020-03 女性研究者・職員向け研修「次世代型インクルーシブ・リーダーの育成」 ダイバーシティ研究環境イニシアティブ 2019-10 -- 2019-10 Tsukuba Scientific English Conference 2019 Tsukuba Global Science Week 2018-09 -- 2018-09 TGSW 2018 Beyond the border つくばグローバルサイエンスウィーク 2018-06 -- 2018-06 上位層育成プログラム「多様な人材の評価」オープンセッション ダイバーシティ研究環境実現イニシアティブ 2017-12 -- 2017-12 ダイバーシティリーダー育成講座 III, TIDE シンポジウム ダイバーシティ研究環境実現イニシアティブ 2017-11 -- 2017-11 ダイバーシティリーダー育成講座 II 「女性研究者・技術者がリーダーシップを発揮する活動テーマとチームを組織横断で生み出そう!」 ダイバーシティー研究環境実現イニシアティブ 2017-03 -- 2017-03 アンコンシャス・バイアスのインパクトとマネジメント ラウンドテーブル ディスカッション ダイバーシティ・アクセシビリティー・キャリアセンター 2017-07 -- 2017-07 ダイバーシティーリーダー育成講座 I 「女性のネットワーキング・組織化と活用ーCOSMOSの歴史から学ぶー」 ダイバーシティー研究環境実現イニシアティブ more... - Professional activities
2022-01 -- (current) International Society for Matrix Biology Council member 2022-01 -- (current) Matrix Biology Editor 2021-12 -- (current) Vascular Pharmacology Editorial Board Member 2021-09 -- (current) Frontiers in Cardiovascular Medicine Associate Editor (Atherosclerosis and Vascular Medicine) 2021-04 -- (current) Frontiers in Cell and Developmental Biology Guest Editor (Extracellular Matrix Dynamics in Biology, Bioengineering and Pathology -Volume II) 2020-11 -- 2023-11 Jananese Society for Matirx Biology and Medicine 理事 2020-09 -- 2022-10 22nd International Vascular Biology Meeting International Scientific Advisory Board 2020 -- (current) Cells Editorial Board Member 2020-07 -- (current) North American Vascular Biology Organization NAVBO Diversity committee 2019 -- 2022 日本血管生物医学会 評議員 more... - University Management
2021 -- (current) HBP 学位論文審査委員会 委員 2020 -- 2021 学長補佐室 室員 2019 -- (current) ヒューマニクス学位プログラム 広報委員会 委員、広報委員長(2020-) 2019 -- (current) TARA センター センター長特別補佐 2018 -- (current) Humanics Graduate Program Faculty Mentor 2018 -- (current) HBP運営委員会 委員 2017 -- (current) HBP教務委員会 委員, 教務委員長(2019-2021) 2017 -- (current) 医学医療系生命医科学域運営委員会 委員 2016 -- 2018 筑波大学研究戦略室 室員 2015 -- (current) TARAセンター運営委員会 委員 more...
(Last updated: 2023-01-04)