YANAGISAWA Hiromi
- Affiliation
- Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA)
- Official title
- Professor
- ORCID
- 0000-0002-7576-9186
- KAKEN ID
- 40746301
- URL
- %CFT<I<BDN<R<^kk<O^kkO<M<gONPFP=<g<>gEK
- Office
- Extracellular environment and cellular responses in development and disease
- Phone
- 029-853-7318
- Research fields
Cardiovascular medicine General medical chemistry Cardiovascular surgery Pathological medical chemistry - Research keywords
extracellular microenvironment extracellular matrix aortic dissection vascular injury and vascular remodeling heritable thoracic aortic disease (HTAD) vascular biology mechanobiology elastic fibers biomechanics Raman Imaging more... - Research projects
Contribution of immune cells to vascular wall damage and dissection in Marfan Syndrome 2024-07 -- 2025-06 Hiromi Yanagisawa Marfan Fundation/Everest Grant 9,563,112Yen メカノセンシング機構の破綻による大動脈疾患の病態解明とバイオマーカー診断法の開発 2024-04 -- 2025-03 Hiromi Yanagisawa 国立研究開発法人日本医療研究開発機構/循環器疾患・糖尿病等生活習慣病対策実用化研究事業/ 19,500,000Yen メカノセンシング機構の破綻による大動脈疾患の病態解明とバイオマーカー診断法の開発 2023-06 -- 2024-03 Hiromi Yanagisawa Japan Agency for Medical Research and Development (AMED)/循環器疾患・糖尿病等生活習慣病対策実用化研究事業 19,500,000Yen 細胞外マトリクスを基軸とした胸部大動脈疾患の発生機序の解明と新規治療法の開発 2023-04 -- 2027-03 Hiromi Yanagisawa 科学研究費補助金/科学研究費補助金 基盤研究(A) 46,800,000Yen 新規大動脈解離マウスモデルを用いたマルファン症候群等類縁疾患の大動脈解離発症機序の解明 2023-04 -- 2024-03 Hiromi Yanagisawa Japan Agency for Medical Research and Development (AMED)/AMED難治性疾患実用化研究事業 11,310,000Yen 柳沢研究室への支援 2023-03 -- (current) 柳沢裕美 筑波大学/奨学寄付金 10,000,000Yen 新規大動脈解離マウスモデルを用いたマルファン症候群等類縁疾患の大動脈解離発症機序の解明 2022-04 -- 2023-03 Hiromi Yanagisawa Japan Agency for Medical Research and Development (AMED)/AMED難治性疾患実用化研究事業 11,830,000Yen ミクロフィブリル変異による大動脈解離の病態解明 2021-10 -- 2025-03 Hiromi Yanagisawa Japan Society of for the Promotion of Science/国際共同研究加速基金(国際共同研究強化(B)) 19,110,000Yen 新規大動脈解離マウスモデルを用いたマルファン症候群等類縁疾患の大動脈解離発症機序の解明 2021-04 -- 2022-03 Yanagisawa, Hiromi The Japan Agency for Medical Research and Development (AMED)/AMED難治性疾患実用化研究事業 15,860,000Yen メカノトランスダクションを基軸とした大動脈瘤発症機序の解明と破裂予測の基盤研究 2020-04 -- 2023-03 Hiromi Yanagisawa JSPS/Grant-in-Aid for Scientific Research (B) 17,810,000Yen more... - Career history
2024-04 -- (current) 筑波大学TARAセンター センター長・教授 2015-09 -- (current) University of TsukubaTARA CenterProfessor 2014-09 -- 2015-08 University of TsukubaTARA CenterProfessor 2011-09 -- 2015-08 University of Texas Southwestern Medical Center at DallasDepartment of Molecular BiologyAssociate Professor (Tenured) 2003-09 -- 2011-08 University of Texas Southwestern Medical Center at DallasDepartment of Molecular BiologyAssistant Professor 1999-09 -- 2003-08 University of Texas Southwestern Medical Center at DallasDepartment of Molecular BiologyInstructor 1998-01 -- 1999-08 University of Texas Southwestern Medical CenterDepartment of Molecular Biologyポスドク研究員 1991-10 -- 1997-12 University of Texas Southwestern Medical CenterDepartment of Biochemistryポスドク研究員 1986-06 -- 1988-03 University of Tsukuba HospitalInternal Medicineレジデント - Academic background
1980 -- 1986 University of Tsukuba School of Medicine - Degree
1993-03 Ph.D. University of Tsukuba - Licenses and qualifications
1986 医師免許証 - Academic societies
2024-04 -- 2027-03 Japanese Society for Matrix Biology and Medicine 2022 -- (current) European Society of Cardiology 2022-01 -- (current) International Society for Matrix Biology 2021-07 -- (current) THE JAPANESE SOCIETY FOR CARDIOVASCULAR SURGERY 2019 -- (current) The Molecular Biology Society of Japan 2019 -- (current) The Japanese Biochemical Society 2016 -- (current) 日本循環器学会 2015 -- (current) 日本心血管内分泌代謝学会 2015 -- (current) 日本血管生物医学会 2015 -- (current) Jananese Society for Matirx Biology and Medicine more... - Honors & Awards
2024-02 Best Faculty Member 2023 2016 Mizutani Foundation for Glycoscience 2015 内藤記念科学財団研究助成 2015 上原記念生命科学財団研究助成 2012 Established Investigator Award (AHA) 2008 Junior Investigator Award (ASMB) - Articles
- Fibrillin-1 G234D mutation in the hybrid1 domain causes tight skin associated with dysregulated elastogenesis and increased collagen cross-linking in mice
Hossain ASM Sakhawat; Clarin Maria Thea Rane Dela Cruz; ...
MATRIX BIOLOGY, 2024-11 - Novel Insights into the Aortic Mechanical Properties of Mice Modeling Hereditary Aortic Diseases
Dubacher Nicolo; Sugiyama Kaori; Smith Jeffrey D.; Nus...
THROMBOSIS AND HAEMOSTASIS/Epub, 2024-07 - A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta
Kimura Kenichi; Motoyama Eri; Kanki Sachiko; Asano Ke...
Biorxiv, 2024-05-07 - Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging
Oinam Lalhaba; Changarathil Gopakumar; ERNA RAJA; Ngo ...
Aging cell, 2020-08 - Cardiac and perivascular myofibroblasts, matrifibrocytes, and immune fibrocytes in hypertension; commonalities and differences with myocardial infarction and other cardiovascular diseases
Torimoto Keiichi; Elliott Katherine; Nakayama Yuki; Ya...
Cardiovascular research, 2024-04 - Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin
Raja Erna; Clarin Maria Thea Rane Dela Cruz; Yanagisawa...
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES/24(18)/p.14274, 2023-09 - Unraveling the Role of TGFβ Signaling in Thoracic Aortic Aneurysm and Dissection Using Fbn1 Mutant Mouse Models
Violette Deleeuw; Carlson Eric; Renard Marjolijn; Zien...
MATRIX BIOLOGY/123/pp.17-33, 2023-09 - Protective Role of Endothelial Fibulin-4 in Valvulo-Arterial Integrity
Nguyen Tram Anh Vu; Lino Caroline Antunes; Hang Huynh ...
Journal of the American Heart Association/12(1), 2023-01-03 - Partial endothelial-to-mesenchymal transition mediated by HIF-induced CD45 in neointima formation upon carotid artery ligation
Yamashiro Yoshito; Ramirez Karina; Nagayama Kazuaki; H...
CARDIOVASCULAR RESEARCH/119(7)/pp.1606-1618, 2022-12-20 - Fibulin7 aggravates calcium oxalate-induced acute kidney injury by binding to calcium oxalate crystals
Sugiura Hidekazu; Tsunezumi Jun; Yanagisawa Hiromi; Futay...
JOURNAL OF CELLULAR PHYSIOLOGY/238(1)/pp.165-178, 2022-11-12 - TBX1 targets the miR-200-ZEB2 axis to induce epithelial differentiation and inhibit stem cell properties
Funato Noriko; Yanagisawa Hiromi
SCIENTIFIC REPORTS/12(1), 2022-11-23 - Editorial: Extracellular matrix dynamics in biology, bioengineering, and pathology, volume II
Loganathan Rajprasad; Yanagisawa Hiromi; Gentleman Eil...
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY/10, 2022-04-01 - The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging
Erna Raja; Changarathil Gopakumar; Oinam Lalhaba; Tsun...
EMBO REPORTS, 2022-10 - The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging
RAJA ERNA; Changarathil Gopakumar; Oinam Lalhaba; Tsun...
EMBO REPORTS/23(12), 2022-10 - Embracing Diversity, Equity, and Inclusion in the Scientific Community-Viewpoints of the Diversity, Equity, and Inclusion Committee of the North American Vascular Biology Organization
Garelnabi Mahdi; Cowdin Mitzy; Fang Yun; Shrestha Ban...
FRONTIERS IN CARDIOVASCULAR MEDICINE/9, 2022-04-01 - Experimental and Mouse-Specific Computational Models of the Fbln4 Mouse to Identify Potential Biomarkers for Ascending Thoracic Aortic Aneurysm
Bazzi Marisa S; Balouchzadeh Ramin; Pavey Shawn N; Qui...
Cardiovascular engineering and technology/Epub, 2022-01-22 - Isolation and Culture of Primary Oral Keratinocytes from the Adult Mouse Palate
Ngo Yen Xuan; Haga Kenta; Suzuki Ayako; Kato Hiroko; Yana...
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS/(175), 2021-09 - Extracellular matrix-mediated remodeling and mechanotransduction in large vessels during development and disease
Yanagisawa Hiromi; Yokoyama Utako
Cellular Signaling/86, 2021-08 - Raman microspectroscopy and Raman imaging reveal biomarkers specific for thoracic aortic aneurysms
Sugiyama Kaori; Marzi Julia; Alber Julia; Brauchle Eva M...
Cell Reports Medicine/2(5), 2021-05 - Contribution of PDGFRα-positive cells in maintenance and injury responses in mouse large vessels
Kimura Kenichi; Ramirez Karina; Nguyen Tram Anh Vu; Yamas...
Scientific Reports/11, 2021-04 - Defining compartmentalized stem cell populations with distinct cell division dynamics in the ocular surface epithelium
Ishii Ryutaro; Yanagisawa Hiromi; Sada Aiko
Development (Cambridge, England)/147(24), 2020-12 - Dysregulated assembly of elastic fibers in fibulin-5 knockout mice results in a tendon-specific increase in elastic modulus
Eekhoff Jeremy D; Steenbock Heiko; Berke Ian M; Brinck...
Journal of the mechanical behavior of biomedical materials/113, 2020-10 - The molecular mechanism of mechanotransduction in vascular homeostasis and disease
Yamashiro Yoshito; Yanagisawa Hiromi
Clinical science (London, England : 1979)/134(17)/pp.2399-2418, 2020-09 - Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging
Oinam Lalhaba; Changarathil Gopakumar; Raja Erna; Ngo Ye...
Aging cell/19(8), 2020-07 - TBX1 Regulates Chondrocyte Maturation in the Spheno-occipital Synchondrosis
Funato N.; Srivastava D.; Shibata S.; Yanagisawa H.
JOURNAL OF DENTAL RESEARCH/99(10)/pp.1182-1191, 2020-05 - more...
- Fibrillin-1 G234D mutation in the hybrid1 domain causes tight skin associated with dysregulated elastogenesis and increased collagen cross-linking in mice
- Books
- Mechanobiology of aortic cells and extracellular matrix
Kailash Keshav; Clarin Maria Thea Rane Dela Cruz; Sheik...
Biomechanics of the Aorta: Modelling for Patient Care/Elsevier, 2024-06 - メカノバイオロジーと研究
山城義人; 柳沢裕美
血管・リンパ管の機能制御と疾患メカニズム/化学同人, 2022-08 - 大動脈瘤への分子生物学的アプローチ
木村 健一; 柳沢裕美
心臓/日本医学出版, 2022-06 - Epidermal stem cell lineages
Oinam L; Changarathil G; Ngo YX; Yanagisawa H; *Sada A
Advances in Stem Cells and their Niches, 2019-04
- Mechanobiology of aortic cells and extracellular matrix
- Conference, etc.
- Phenotypic changes of endothelial cells in the pathogenesis of aortic dissection.
Kimura Kenichi; Motoyama Eri; Kanki Sachiko; Asano Ke...
CVMW 2024/2024-12-07--2024-12-08 - 遺伝性胸部大動脈疾患におけるメカノトランスダクション異常
柳沢裕美; 木村健一; 本山絵理; 浅野恵一; 神吉佐知子
CVMW 2024/2024-12-07--2024-12-08 - フィブリリン1遺伝子変異による大動脈解離病態に関わる血管内皮細胞の機能解析
本山 絵理; 木村 健一; 浅野 恵一; 神吉 佐知子; 中邨 智之; 柳沢 裕美
第8回エラスチン・関連分子研究会/2024-11-30--2024-12-01 - 骨髄ニッチにおけるミクロフィブリルを介した造血制御機構の解明
木村 健一; 本山 絵理; 神吉 佐知子; 柳沢 裕美
第8回エラスチン・関連分子研究会/2024-11-30--2024-12-01 - 軟骨組織におけるCD73陽性細胞の細胞系譜解析
Sanaki-Matsumiya Marina; Hosomi Nao; Yanagisawa Hiromi...
第47回日本分子生物学会年会/2024-11-27--2024-11-29 - Phenotypic changes of endothelial cells in the pathogenesis of aortic dissection.
Kimura Kenichi; Motoyama Eri; Kanki Sachiko; Asano Ke...
第47回日本分子生物学会年会/2024-11-27--2024-11-29 - Role of CD73-lineage cells in articular cartilage degeneration and remodeling in osteoarthritis
Hosomi Nao; Matsumiya Marina; Yanagisawa Hiromi; Kimur...
Tsukuba Global Science Week 2024/2024-10-03--2024-10-04 - Investigation of the molecular pathogenesis of aortic dissection in new Fibrillin 1 mutant mice by synchrotron imaging and transcriptomics analysis
Sheikh Md Al Amin; Kimura Kenichi; Motoyama Eri; Delee...
Tsukuba Global Science Week 2024/2024-10-03--2024-10-04 - Anti-inflammatory Nanoparticles as Potential Treatment for Aortic Dissection
Clarin M.T.R.D.C.; Motoyama Eri; A. Nabil; Kanki Sach...
NIMS Award Symposium/2024-11-06--2024-11-07 - Nanoparticles as a potential therapeutic tool for targeting M1 macrophages in Aortic Dissection
Clarin M.T.R.D.C.; Motoyama Eri; A. Nabil; Kanki Sach...
Tsukuba Global Science Week 2024/2024-10-03--2024-10-04 - Aortic rupture force in mice modelling hereditary aortic diseases
Dubacher Nicolo; Sugiyama Kaori; Smith Jeffrey; Nussba...
EUROPEAN JOURNAL OF HUMAN GENETICS/2023-05-11 - Converting one differentiated cell identity into another: Insights from Drosophila enteroendocrine cells
Qian Qingyin; Hayashi Makoto; Nagai Hiroki; Kimura Ke...
The 16th Japanese Drosophila Research Conference (JDRC16)/2024-09-17--2024-09-19 - A Smart Nanofiber-based Therapeutic Approach for Aortic Dissection by Targeting Sympathetic Innervation
LI Kai; Kimura Kenichi; Motoyama Eri; Fujisawa Nanami...
第56回日本結合組織学会学術大会/2024-06-15--2024-06-16 - Nanoparticles as a potential therapeutic tool for targeting M1 macrophages in Aortic Dissection
Cruz Maria Thea Rane Dela; Motoyama Eri; Ahmed Nabil; ...
第56回日本結合組織学会学術大会/2024-06-15--2024-06-16 - Fibrillin-1 G234D mutation links mouse skin tightness to elastic fiber defects and collagen cross-linking
Hossain ASM Sakhawat; Cruz Maria Thea Rane Dela; Kimura...
第56回日本結合組織学会学術大会/2024-06-15--2024-06-16 - Investigation of the molecular pathogenesis of aortic dissection in new Fibrillin 1 mutant mice by synchrotron imaging and transcriptomics analysis
Sheikh Md Al Amin; Kimura Kenichi; Motoyama Eri; Delee...
第56回日本結合組織学会学術大会/2024-06-15--2024-06-16 - Investigation of mechanosensing mechanisms in aortic dissection caused by a missense variant in the fibrillin-1
本山 絵理; 木村 健一; Maria Thea Rane Dela Cruz Clarin; 浅野 恵一...
第56回日本結合組織学会学術大会/2024-06-15--2024-06-16 - A Smart Nanofiber-based Therapeutic Approach for Aortic Dissection by Targeting Sympathetic Innervation
LI Kai; Chen Lili; Fujisawa Nanami; Kimura Kenichi; M...
The 40th annual meeting of JSDDS/2024-07-09--2024-07-11 - CELL LINEAGE ANALYSIS OF CD73-POSITIVE CELLS IN OSTEOCHONDRAL TISSUE
Kimura Kenichi; Ishi Ryutaro; Yanagisawa Hiromi
The International Society for Stem Cell Research 2024/2024-07-09--2024-07-13 - Phenotypic changes of endothelial cells in the pathogenesis of aortic dissection.
Kimura Kenichi; Motoyama Eri; Kanki Sachiko; Asano Ke...
International Vascular Biology Meeting 2024/2024-07-02--2024-07-02 - Development of nanoparticles to induce M1-to-M2 switch as a treatment for aortic dissection in Fbn1 mutant mice.
Clarin M.T.R.D.C.; E. Motoyama; A. Nabil; S. Kanki; U...
International Vascular Biology Meeting 2024/2024-07-02--2024-07-05 - Development of nanoparticles to induce M1-to-M2 switch as a treatment for aortic dissection in Fbn1 mutant mice.
Clarin M.T.R.D.C.; E. Motoyama; A. Nabil; S. Kanki; K...
World Biomaterials Congress/2024-05-27--2024-05-31 - Investigation of the role of macrophages in Fbn1 mutant mice and development of therapeutic strategy for aortic dissection.
Clarin M.T.R.D.C; Motoyama Eri; A Nabil; Kanki Sachik...
the annual Tsukuba Global Science Week (TGSW) 2023/2023-09-27--2023-09-28 - Treatment for Aortic Dissection Using Nanoparticles to Target M1 Macrophages.
Clarin M.T.R.D.C.; Motoyama E; Nabil A; Kanki S; Kimu...
Tsukuba Biomedical Engineering Forum/2024-01-19 - Cell-matrix interactions in the maintenance of vascular wall
柳沢 裕美
Korean Society for Biochemistry and Molecular Biology/2023-5-11 - more...
- Phenotypic changes of endothelial cells in the pathogenesis of aortic dissection.
- Teaching
2024-04 -- 2024-08 Special Research in Humanics IIIa University of Tsukuba. 2024-10 -- 2025-02 Special Seminars in Humanics IIIb University of Tsukuba. 2024-10 -- 2025-02 Basic Experiments in Human Biology University of Tsukuba. 2024-04 -- 2024-08 Special Seminars in Human Biology I University of Tsukuba. 2024-10 -- 2025-02 Special Lectures in Humanics IIIb University of Tsukuba. 2024-04 -- 2024-08 Special Lectures in Humanics IIIa University of Tsukuba. 2024-04 -- 2024-08 Special Seminars in Humanics IIIa University of Tsukuba. 2024-10 -- 2025-02 Special Seminars in Human Biology II University of Tsukuba. 2024-10 -- 2025-02 Special Lectures in Human Biology II University of Tsukuba. 2024-10 -- 2025-02 Special Research in Human Biology II University of Tsukuba. more... - Other educational activities
2024-07 -- 2024-07 医学医療系FD講習会 筑波大学医学医療系 ゆりのき通りでキャリアを考える会 2024-02 -- 2024-02 IDWGIS Symposium 2024 (International Day of Women and Girls in Science Symposium 2024) RIKEN BDR 2023-07 -- 2023-07 Power Hour at GRC (Organizer) Gordon Research Conference 2022-10 -- 2022-10 Roundtable Discussion at IVBM 2022: Empowerment Roundtable for Advancement of Gender Equity International Vascular Biology Meeting 2022 2021-10 -- 2021-10 Women’s Empowerment Roundtable at NAVBO North American Vascular Biology Organization 2021-05 -- 2021-05 世界のトップサイエンティストの男女共同参画 第62回日本神経学会 2020-12 -- 2020-12 「イノベーションを支える多様な人材の活躍に向 けて~次期科学技術・イノベーション基本計画の共創に向けた全国キャラバン(つく ば開催)~」 つくば女性研究者協議会・内閣府・つくば市 2020-03 -- 2020-03 女性研究者・職員向け研修「次世代型インクルーシブ・リーダーの育成」 ダイバーシティ研究環境イニシアティブ 2019-10 -- 2019-10 Tsukuba Scientific English Conference 2019 Tsukuba Global Science Week 2018-09 -- 2018-09 TGSW 2018 Beyond the border つくばグローバルサイエンスウィーク more... - Professional activities
2022-01 -- (current) International Society for Matrix Biology Council member 2022-01 -- (current) Matrix Biology Editor 2021-12 -- (current) Vascular Pharmacology Editorial Board Member 2021-09 -- (current) Frontiers in Cardiovascular Medicine Associate Editor (Atherosclerosis and Vascular Medicine) 2021-04 -- (current) Frontiers in Cell and Developmental Biology Guest Editor (Extracellular Matrix Dynamics in Biology, Bioengineering and Pathology -Volume II) 2020-11 -- 2023-11 Jananese Society for Matirx Biology and Medicine 理事 2020-09 -- 2022-10 22nd International Vascular Biology Meeting International Scientific Advisory Board 2020 -- (current) Cells Editorial Board Member 2020-07 -- (current) North American Vascular Biology Organization NAVBO Diversity committee 2019 -- 2022 日本血管生物医学会 評議員 more... - University Management
2021 -- (current) HBP 学位論文審査委員会 委員 2020 -- 2021 学長補佐室 室員 2019 -- (current) ヒューマニクス学位プログラム 広報委員会 委員、広報委員長(2020-) 2019 -- (current) TARA センター センター長特別補佐 2018 -- (current) Humanics Graduate Program Faculty Mentor 2018 -- (current) HBP運営委員会 委員 2017 -- (current) HBP教務委員会 委員, 教務委員長(2019-2021) 2017 -- (current) 医学医療系生命医科学域運営委員会 委員 2016 -- 2018 筑波大学研究戦略室 室員 2015 -- (current) TARAセンター運営委員会 委員 more...
(Last updated: 2024-11-25)