萩原 大祐(ハギワラ ダイスケ; Hagiwara, Daisuke)

所属

生命環境系

職名

准教授

研究分野

応用微生物学

細菌学（含真菌学）

研究キーワード

環境応答、シグナル伝達、病原性、薬剤耐性、トランスクリプトーム

所属学協会

-- (現在)	日本農芸化学会
-- (現在)	日本医真菌学会
-- (現在)	日本ゲノム微生物学会
-- (現在)	糸状菌分子生物学研究会

査読付き学術雑誌・国際会議論文

• Epidemiological and Genomic Landscape of Azole Resistance Mechanisms in Aspergillus Fungi
  Hagiwara Daisuke; A Watanabe; K Kamei; GH Goldman
  Front Microbiol, 2016-09
  PubMed
• Comparative transcriptome analysis revealing dormant conidia and germination associated genes in Aspergillus species: an essential role for AtfA in conidial dormancy
  Hagiwara Daisuke; H Takahashi; Y Kusuya; S Kawamoto; K Ka...
  BMC Genomics, 2016-05
  PubMed
• Genome-wide transcriptome analysis of Aspergillus fumigatus exposed to osmotic stress reveals regulators of osmotic and cell wall stresses that are SakA(HOG1) and MpkC dependent
  L Pereira Silva; P Alves de Castro; TF Dos Reis; MH Pazia...
  Cell Microbiol, 2017-04
  PubMed
• A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions
  Hagiwara Daisuke; D Miura; K Shimizu; S Paul; A Ohba; T G...
  PLoS Pathog, 2017-01
  PubMed
• First clinical isolation report of azole-resistant Aspergillus fumigatus with TR(34)/L98H-type mutation in Japan
  T Toyotome; Hagiwara Daisuke; H Kida; T Ogi; A Watanabe; ...
  J Infect Chemother, 2017-01
  PubMed
• Transcription factor Afmac1 controls copper import machinery in Aspergillus fumigatus
  Y Kusuya; Hagiwara Daisuke; K Sakai; T Yaguchi; T Gonoi; ...
  Curr Genet, 2017-08
  PubMed
• Temperature during conidiation affects stress tolerance, pigmentation, and trypacidin accumulation in the conidia of the airborne pathogen Aspergillus fumigatus
  Hagiwara Daisuke; K Sakai; S Suzuki; M Umemura; T Nogawa;...
  PLoS One, 2017-05
  PubMed
• Azole-resistant Aspergillus fumigatus Containing a 34-bp Tandem Repeat in cyp51A Promoter is Isolated from the Environment in Japan
  K Onishi; B Muhammad Sarumoh; Hagiwara Daisuke; A Watanab...
  Med Mycol J, 2017-05
  PubMed
• Drug Sensitivity and Resistance Mechanism in Aspergillus Section Nigri Strains from Japan
  A Hashimoto; Hagiwara Daisuke; A Watanabe; M Yahiro; A Yi...
  Antimicrob Agents Chemother, 2017-08
  PubMed
• Aspergillus fumigatus adhesion factors in dormant conidia revealed through comparative phenotypic and transcriptomic analyses
  A Takahashi-Nakaguchi; K Sakai; H Takahashi; Hagiwara Dai...
  Cell Microbiol, 2018-03
  PubMed
• Global gene expression reveals stress-responsive genes in Aspergillus fumigatus mycelia
  H Takahashi; Y Kusuya; Hagiwara Daisuke; A Takahashi-Naka...
  BMC Genomics, 2017-12
  PubMed
• A simple method to detect the tandem repeat of the cyp51A promoter in azole-resistant strains of Aspergillus fumigatus
  Toyotome T; Hagiwara D; Watanabe A; Kamei K
  Med Mycol, 2018-01
  PubMed
• 次世代シークエンサーを活用したオミクス解析によるAspergillus fumigatus 病原因子探索
  髙橋 (中口) 梓; 萩原 大祐; 高橋弘喜; 酒井香奈江; 豊留孝仁...
  日本医真菌学会雑誌, 2018-03
• Regulation of genes encoding cellulolytic enzymes by Pal-PacC signaling in Aspergillus nidulans.
  E Kunitake; D Hagiwara; K Miyamoto; K Kanamaru; M Kimura;...
  Applied microbiology and biotechnology/100(8)/pp.3621-3635, 2016-04
  PubMed
• Signaling pathways for stress responses and adaptation in Aspergillus species: stress biology in the post-genomic era.
  D Hagiwara; K Sakamoto; K Abe; K Gomi
  Bioscience, biotechnology, and biochemistry/pp.1-14, 2016-03
  PubMed
• Mitogen activated protein kinases SakA^HOG1 and MpkC collaborate for Aspergillus fumigatus virulence.
  Oliveira Bruder Nascimento AC de; Reis TF Dos; Castro PA ...
  Molecular microbiology, 2016-02
  PubMed
• Multi-azole resistant Aspergillus fumigatus harboring Cyp51A TR₄₆/Y121F/T289A isolated in Japan.
  D Hagiwara; H Takahashi; M Fujimoto; M Sugahara; Y Misawa...
  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2016-02
  PubMed
• Functional Analysis of Sterol Transporter Orthologues in the Filamentous Fungus Aspergillus nidulans
  Buehler Nicole; Hagiwara Daisuke; Takeshita Norio
  EUKARYOTIC CELL/14(9)/pp.908-921, 2015-09
  PubMed
• The Aspergillus fumigatus sitA Phosphatase Homologue Is Important for Adhesion, Cell Wall Integrity, Biofilm Formation, and Virulence.
  VL Bom; Castro PA de; Winkelströter LK; M Marine; JI Hori...
  Eukaryotic cell/14(8)/pp.728-744, 2015-08
  PubMed
• Genome sequence comparison of Aspergillus fumigatus strains isolated from patients with pulmonary aspergilloma and chronic necrotizing pulmonary aspergillosis.
  A Takahashi-Nakaguchi; Y Muraosa; D Hagiwara; K Sakai; T ...
  Medical mycology/53(4)/pp.353-360, 2015-05
  PubMed
• Systematic Global Analysis of Genes Encoding Protein Phosphatases in Aspergillus fumigatus.
  Winkelströter LK; SK Dolan; Dos Reis T Fernanda; VL Bom; ...
  G3 (Bethesda, Md.)/5(7)/pp.1525-1539, 2015-05
  PubMed
• High osmolarity glycerol response PtcB phosphatase is important for Aspergillus fumigatus virulence.
  Winkelströter LK; VL Bom; Castro PA de; LN Ramalho; MH Go...
  Molecular microbiology/96(1)/pp.42-54, 2015-04
  PubMed
• Mitogen-activated protein kinases MpkA and MpkB independently affect micafungin sensitivity in Aspergillus nidulans.
  A Yoshimi; T Fujioka; O Mizutani; J Marui; D Hagiwara; K Abe
  Bioscience, biotechnology, and biochemistry/79(5)/pp.836-844, 2015-01
  PubMed
• The role of AtfA and HOG MAPK pathway in stress tolerance in conidia of Aspergillus fumigatus.
  D Hagiwara; S Suzuki; K Kamei; T Gonoi; S Kawamoto
  Fungal genetics and biology : FG & B/73/pp.138-149, 2014-12
  PubMed
• Whole-genome comparison of Aspergillus fumigatus strains serially isolated from patients with aspergillosis.
  D Hagiwara; H Takahashi; A Watanabe; A Takahashi-Nakaguch...
  Journal of clinical microbiology/52(12)/pp.4202-4209, 2014-12
  PubMed

more...

その他の論文・記事

• Sensitisation of an Azole-Resistant Aspergillus fumigatus Strain containing the Cyp51A-Related Mutation by Deleting the SrbA Gene
  萩原 大祐; Watanabe A; Kamei K
  Sci Rep., 2016-12
  PubMed
• 糸状菌ゲノムから紐解く二次代謝の多様性
  萩原 大祐
  マイコトキシン/68(2)/pp.89-92, 2018
  CiNii

著書

• Aspergillus: Molecular Biology and Genomics
  Daisuke Hagiwara
  Caister Academic Press, 2010-01
• Stress Biology of Yeasts and Fungi: Applications for Industrial Brewing and Fermentation
  Daisuke Hagiwara
  Springer, 2015-02

担当授業科目

2018-10 -- 2019-02	糸状菌相互応答学特論	筑波大学
2018-10 -- 2019-02	糸状菌相互応答学演習I	筑波大学
2018-10 -- 2019-02	糸状菌相互応答学演習II	筑波大学
2018-10 -- 2019-02	糸状菌相互応答学特別研究II	筑波大学
2018-10 -- 2019-02	糸状菌相互応答学特別研究I	筑波大学
2018-10 -- 2019-02	糸状菌相互応答学講究I	筑波大学
2018-10 -- 2019-02	糸状菌相互応答学講究II	筑波大学
2018-10 -- 2019-02	糸状菌相互応答学講究III	筑波大学
2018-04 -- 2018-08	糸状菌相互応答学特論	筑波大学
2018-04 -- 2018-08	糸状菌相互応答学演習I	筑波大学

more...

(最終更新日: 2018-07-02)