萩原 大祐(ハギワラ ダイスケ; Hagiwara, Daisuke)

所属

生命環境系

職名

准教授

研究分野

応用微生物学

細菌学（含真菌学）

研究キーワード

環境応答、シグナル伝達、病原性、薬剤耐性、トランスクリプトーム

取得学位

2006-03

博士（農学）

名古屋大学

所属学協会

-- (現在)	日本農芸化学会
-- (現在)	日本医真菌学会
-- (現在)	日本ゲノム微生物学会
-- (現在)	糸状菌分子生物学研究会

査読付き学術雑誌・国際会議論文

• Nutritional Heterogeneity Among Strains Has Consequences for Virulence in a Strain- and Host-Dependent Manner
  Ries Laure Nicolas Annick; Steenwyk Jacob L; de Castro Pa...
  Frontiers in microbiology/10/p.854, 2019-04
  PubMed
• A Novel Antifungal Compound Z-705 Specifically Inhibits Protein Kinase C of Filamentous Fungi
  Sugahara Asumi; Yoshimi Akira; Shoji Fumio; Fujioka Tomon...
  Applied and environmental microbiology/85(10), 2019-03
  PubMed
• AtrR Is an Essential Determinant of Azole Resistance in Aspergillus fumigatus
  Paul Sanjoy; Stamnes Mark; Thomas Grace Heredge; Liu Hong...
  mBio/10(2), 2019-03
  PubMed
• Heterogeneity in Pathogenicity-related Properties and Stress Tolerance in Aspergillus fumigatus Clinical Isolates
  Hagiwara Daisuke; Takahashi Hiroki; Takagi Hiroshi; Watan...
  Medical Mycology Journal/59(4)/pp.E63-E70, 2018-04
  CiNii PubMed
• Current Status of Azole-resistant Aspergillus fumigatus Isolates in East Asia:China, Japan, Korea, and Taiwan
  Hagiwara Daisuke
  Medical mycology journal/59(4)/pp.E71-E76, 2018-04
  CiNii PubMed
• Protein Kinase A and High-Osmolarity Glycerol Response Pathways Cooperatively Control Cell Wall Carbohydrate Mobilization in
  de Assis Leandro José; Manfiolli Adriana; Mattos Eliciane...
  mBio/9(6), 2018-11
  PubMed
• Emerging Antifungal Drug Resistance in Aspergillus fumigatus and Among Other Species of Aspergillus
  Toyotome Takahito; Hagiwara Daisuke; Takahashi Hiroki; Wa...
  CURRENT FUNGAL INFECTION REPORTS/12(3)/pp.105-111, 2018-09
• Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase
  Hagiwara Daisuke; Arai Teppei; Takahashi Hiroki; Kusuya Y...
  EMERGING INFECTIOUS DISEASES/24(10)/pp.1889-1897, 2018-10
• Epidemiological and Genomic Landscape of Azole Resistance Mechanisms in Aspergillus Fungi
  Hagiwara Daisuke; A Watanabe; K Kamei; GH Goldman
  Front Microbiol, 2016-09
  PubMed
• Comparative transcriptome analysis revealing dormant conidia and germination associated genes in Aspergillus species: an essential role for AtfA in conidial dormancy
  Hagiwara Daisuke; H Takahashi; Y Kusuya; S Kawamoto; K Ka...
  BMC Genomics, 2016-05
  PubMed
• Genome-wide transcriptome analysis of Aspergillus fumigatus exposed to osmotic stress reveals regulators of osmotic and cell wall stresses that are SakA(HOG1) and MpkC dependent
  L Pereira Silva; P Alves de Castro; TF Dos Reis; MH Pazia...
  Cell Microbiol, 2017-04
  PubMed
• A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions
  Hagiwara Daisuke; D Miura; K Shimizu; S Paul; A Ohba; T G...
  PLoS Pathog, 2017-01
  PubMed
• First clinical isolation report of azole-resistant Aspergillus fumigatus with TR(34)/L98H-type mutation in Japan
  T Toyotome; Hagiwara Daisuke; H Kida; T Ogi; A Watanabe; ...
  J Infect Chemother, 2017-01
  PubMed
• Transcription factor Afmac1 controls copper import machinery in Aspergillus fumigatus
  Y Kusuya; Hagiwara Daisuke; K Sakai; T Yaguchi; T Gonoi; ...
  Curr Genet, 2017-08
  PubMed
• Temperature during conidiation affects stress tolerance, pigmentation, and trypacidin accumulation in the conidia of the airborne pathogen Aspergillus fumigatus
  Hagiwara Daisuke; K Sakai; S Suzuki; M Umemura; T Nogawa;...
  PLoS One, 2017-05
  PubMed
• Azole-resistant Aspergillus fumigatus Containing a 34-bp Tandem Repeat in cyp51A Promoter is Isolated from the Environment in Japan
  K Onishi; B Muhammad Sarumoh; Hagiwara Daisuke; A Watanab...
  Med Mycol J, 2017-05
  PubMed
• Drug Sensitivity and Resistance Mechanism in Aspergillus Section Nigri Strains from Japan
  A Hashimoto; Hagiwara Daisuke; A Watanabe; M Yahiro; A Yi...
  Antimicrob Agents Chemother, 2017-08
  PubMed
• Aspergillus fumigatus adhesion factors in dormant conidia revealed through comparative phenotypic and transcriptomic analyses
  A Takahashi-Nakaguchi; K Sakai; H Takahashi; Hagiwara Dai...
  Cell Microbiol, 2018-03
  PubMed
• Global gene expression reveals stress-responsive genes in Aspergillus fumigatus mycelia
  H Takahashi; Y Kusuya; Hagiwara Daisuke; A Takahashi-Naka...
  BMC Genomics, 2017-12
  PubMed
• A simple method to detect the tandem repeat of the cyp51A promoter in azole-resistant strains of Aspergillus fumigatus
  Toyotome T; Hagiwara D; Watanabe A; Kamei K
  Med Mycol, 2018-01
  PubMed
• 次世代シークエンサーを活用したオミクス解析によるAspergillus fumigatus 病原因子探索
  髙橋 (中口) 梓; 萩原 大祐; 高橋弘喜; 酒井香奈江; 豊留孝仁...
  日本医真菌学会雑誌, 2018-03
• Regulation of genes encoding cellulolytic enzymes by Pal-PacC signaling in Aspergillus nidulans.
  E Kunitake; D Hagiwara; K Miyamoto; K Kanamaru; M Kimura;...
  Applied microbiology and biotechnology/100(8)/pp.3621-3635, 2016-04
  PubMed
• Signaling pathways for stress responses and adaptation in Aspergillus species: stress biology in the post-genomic era.
  D Hagiwara; K Sakamoto; K Abe; K Gomi
  Bioscience, biotechnology, and biochemistry/pp.1-14, 2016-03
  PubMed
• Mitogen activated protein kinases SakA^HOG1 and MpkC collaborate for Aspergillus fumigatus virulence.
  Oliveira Bruder Nascimento AC de; Reis TF Dos; Castro PA ...
  Molecular microbiology, 2016-02
  PubMed
• Multi-azole resistant Aspergillus fumigatus harboring Cyp51A TR₄₆/Y121F/T289A isolated in Japan.
  D Hagiwara; H Takahashi; M Fujimoto; M Sugahara; Y Misawa...
  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2016-02
  PubMed

more...

その他の論文・記事

• Sensitisation of an Azole-Resistant Aspergillus fumigatus Strain containing the Cyp51A-Related Mutation by Deleting the SrbA Gene
  萩原 大祐; Watanabe A; Kamei K
  Sci Rep., 2016-12
  PubMed
• 糸状菌ゲノムから紐解く二次代謝の多様性
  萩原 大祐
  マイコトキシン/68(2)/pp.89-92, 2018
  CiNii

著書

• Aspergillus: Molecular Biology and Genomics
  Daisuke Hagiwara
  Caister Academic Press, 2010-01
• Stress Biology of Yeasts and Fungi: Applications for Industrial Brewing and Fermentation
  Daisuke Hagiwara
  Springer, 2015-02

会議発表等

• Wide variety of ribosomal peptide precursor-like genes in pathogenic fungi at the MMRC National Bioresource
  Umemura Maiko; Hagiwara Daisuke; Toyotome Takahito; Watan...
  The 7th global network forum on infection and immunity/2018-11-30--2018-12-01
• Non-cyp51A azole-resistant Aspergillus fumigatus isolates with mutation in HMG-CoA reductase
  Arai Teppei; Hagiwara Daisuke; Takahashi Hiroki; Kusuya Y...
  The 7th global network forum on infection and immunity/2018-11-30--2018-12-01
• Functional analysis of copper-sensing transcription factors Afmac1 and aceA in Aspergillus fumigatus
  Kusuya Yoko; Bian Cai; Hagiwara Daisuke; Yaguchi Takashi;...
  The 7th global network forum on infection and immunity/2018-11-30--2018-12-01
• Aspergillus fumigatus strains isolated from a single sputum of a chronic aspergillosis patient showed various susceptibilities to azoles
  Anazawa Rie; Kamei Katsuhiko; Hagiwara Daisuke; Yarita Ky...
  The 7th global network forum on infection and immunity/2018-11-30--2018-12-01
• 空間的・代謝的な相互作用を介した細菌と真菌の新たな相利共生戦略
  久知良桃花; Gayan Abeysinghe; 桝尾俊介; 萩原 大祐; 高谷直...
  2019年度日本農芸化学会/2019-03-24--2019-03-27
• Aspergillus fumigatusの銅代謝転写因子Afmac1及びaceAの機能解析
  楠屋陽子; 辺彩; 萩原 大祐; 矢口貴志; 高橋弘喜
  第18回糸状菌分子生物学コンファレンス/2018-11-15--2018-11-16
• 糸状菌間相互作用による二次代謝活性化の機構解明を目指したモデル共培養系の確立
  二宮章洋; 浦山俊一; 萩原 大祐
  2019年度日本農芸化学会/2019-03-24--2019-03-27
• 白癬菌が産生する抗生物質とその生合成遺伝子の探索
  増田圭恭; 二宮章洋; 矢口貴志; 浦山俊一; 萩原 大祐
  2019年度日本農芸化学会/2019-03-24--2019-03-27
• How do fungi get along with other microbes in the ecosystem?
  Hagiwara Daisuke
  Asperfest 16/2019-03-11--2019-03-12
• Enhanced production of antimicrobial polyketides, violaceols in Aspergillus nidulans by co-culture with Aspergillus fumigatus
  Ninomiya Akihiro; Urayama Shun-ichi; Hagiwara Daisuke
  Asperfest 16/2019-03-11--2019-03-12
• Enhanced production of antimicrobial polyketides, violaceols in Aspergillus nidulans by co-culture with Aspergillus fumigatus
  Ninomiya Akihiro; Urayama Shun-ichi; Hagiwara Daisuke
  30th Fungal Genetic Conference/2019-03-12--2019-03-17
• Diversified transcriptional regulation of secondary metabolic gene clusters in closely related Aspergillus species
  Takahashi Hiroki; Umemura Maiko; Ninomiya Akihiro; Shimiz...
  30th Fungal Genetic Conference/2019-03-12--2019-03-17
• Diversified transcriptional regulation of secondary metabolic gene clusters in closely related Aspergillus species
  Takahashi Hiroki; Umemura Maiko; Ninomiya Akihiro; Shimiz...
  Asperfest 16/2019-03-11--2019-03-12
• Aspergillus fumigatusとその近縁種に潜伏するRNAウイルスの網羅的な探索
  千葉悠斗; 浦山俊一; 矢口貴志; 萩原 大祐
  第13回ゲノム微生物学会/2019-03-06--2019-03-08
• Discovery of a novel regulator of azole drug response in Aspergillus fumigatus
  萩原 大祐
  The 7th global network forum on infection and immunity/2018-11-30--2018-12-01
• 二次代謝を活性化する糸状菌間相互作用の探索
  萩原 大祐
  糸状菌分子生物学コンファレンス/2018-11-15--2018-11-16
• RNA-sequencing による糸状菌の一酸化窒素応答の解析
  萩原 大祐
  糸状菌分子生物学コンファレンス/2018-11-15--2018-11-16
• 菌糸ネットワークを介した糸状菌と細菌の相互作用の解析
  久知良桃花; Gayan Abeysinghe; 桝尾俊介; 萩原 大祐; 高谷直...
  糸状菌分子生物学コンファレンス/2018-11-15--2018-11-16

担当授業科目

2019-10 -- 2020-02	糸状菌相互応答学講究I	筑波大学
2019-04 -- 2019-08	糸状菌相互応答学講究I	筑波大学
2019-10 -- 2020-02	糸状菌相互応答学講究III	筑波大学
2019-04 -- 2019-08	糸状菌相互応答学講究III	筑波大学
2019-10 -- 2020-02	糸状菌相互応答学講究II	筑波大学
2019-04 -- 2019-08	糸状菌相互応答学講究II	筑波大学
2019-10 -- 2020-02	糸状菌相互応答学特別研究I	筑波大学
2019-04 -- 2019-08	糸状菌相互応答学特別研究I	筑波大学
2019-04 -- 2019-08	応用生命化学コース専門実験	筑波大学
2019-11 -- 2020-02	生物学実験	筑波大学

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(最終更新日: 2019-08-20)