Kuno Akihiro
- Affiliation
- Institute of Medicine
- Official title
- Assistant Professor
- ORCID
- 0000-0002-4674-6882
- URL
- Office
- Department of Anatomy and Embryology
- Research fields
Laboratory animal science System genome science - Research keywords
Laboratory animal science Genome biology Bioinformatics - Research projects
Development of a universal genome-editing genotype analysis method using a deep generation model 2020-04 -- 2022-03 Akihiro Kuno Ministry of Education, Culture, Sports, Science and Technology, Japan/Grants-in-Aid for Scientific Research: Young Scientists 3,510,000Yen - Career history
2019-06 -- 2022-03 Ph.D. Program in Human Biology, School of Integrative and Global Majors, University of Tsukuba 2018-05 -- (current) Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba - Academic background
2013-04 -- 2018-04 Ph.D. Program in Human Biology, School of Integrative and Global Majors, University of Tsukuba 2007-04 -- 2013-03 University of Tsukuba School of Medicine Department of Medicine - Degree
2018-04 Ph.D. in Human Biology 筑波大学 - Licenses and qualifications
2013-04 Medical license - Academic societies
2022-04 -- (current) The Japanese Society for Genome Editing - Honors & Awards
2022-11 Young Investigator Award 2022-11 医学医療系 教員業績評価 優秀教員賞 - Articles
- A universal method for generating knockout mice in multiple genetic backgrounds using zygote electroporation
Tamari Tomohiro; Ikeda Yoshihisa; Morimoto Kento; Koba...
Biology open/12(9), 2023-09-15 - Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2
Fujino Mitsunori; Morito Naoki; Hayashi Takuto; Ojima Ma...
JCI insight/8(6), 2023-03-22 - Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2
Fujino Mitsunori; Morito Naoki; Hayashi Takuto; Ojima Ma...
JCI insight/8(6), 2023-03-22 - Large Maf transcription factor family is a major regulator of fast type IIb myofiber determination
Sadaki Shunya; Fujita Ryo; Hayashi Takuto; Nakamura Ayan...
Cell Reports, 2023-03 - STRUCTURALLY-DISCOVERED TRANSCRIPTION FACTOR VARIANTS ACCELERATE AND STABILIZE REPROGRAMMING TO PLURIPOTENCY
Borisova Evgeniia; Nishimura Ken; An Yuri; Takami Mih...
TISSUE ENGINEERING PART A/28(1)/pp.S199-S199, 2022-04 - Locus-Specific Isolation of the Nanog Chromatin Identifies Regulators Relevant to Pluripotency of Mouse Embryonic Stem Cells and Reprogramming of Somatic Cells
Burramsetty Arun Kumar; Nishimura Ken; Kishimoto Takum...
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES/23(23), 2022-12-03 - Sufficient liver erythropoietin synthesis is induced in hemodialysis patients not requiring erythropoiesis-stimulating agents
Yanagawa Takamoto; Hirayama Aki; Osada Kayo; Kuno Aki...
CLINICAL NEPHROLOGY/98(3)/pp.167-170, 2022-07-12 - MafB Maintains β-Cell Identity under MafA-Deficient Conditions
Deng Zhaobin; Kuno Akihiro; Ojima Masami; Takahashi S...
MOLECULAR AND CELLULAR BIOLOGY/42(8), 2022-07-11 - Mutational landscape of primary breast angiosarcoma with repeated resection and recurrence over a 15-year period: A case report
Teruyama Fumiya; Kuno Akihiro; Murata Yoshihiko; Nakag...
PATHOLOGY INTERNATIONAL/72(9)/pp.457-463, 2022-07-08 - Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency
Borisova Evgeniia; Nishimura Ken; An Yuri; Takami Miho; L...
iScience/25(1)/p.103525, 2021-12 - Downregulation of Odd-Skipped Related 2, a Novel Regulator of Epithelial-Mesenchymal Transition, Enables Efficient Somatic Cell Reprogramming
Anh Le Phuong Hoang; Nishimura Ken; Kuno Akihiro; Linh N...
Stem cells (Dayton, Ohio)/40(4)/pp.397-410, 2022-04-29 - Early reactivation of clustered genes on the inactive X chromosome during somatic cell reprogramming
Aizawa Shiho; Nishimura Ken; Mondejar Gonzalo Seminario; ...
Stem Cell Reports/17(1)/pp.53-67, 2022-01 - DAJIN enables multiplex genotyping to simultaneously validate intended and unintended target genome editing outcomes
Kuno Akihiro; Ikeda Yoshihisa; Ayabe Shinya; Kato Kanako...
PLOS BIOLOGY/20(1), 2022-01 - Cell-to-cell interaction analysis of prognostic ligand-receptor pairs in human pancreatic ductal adenocarcinoma
Suzuki Sayaka R; Kuno Akihiro; Ozaki Haruka
Biochemistry and biophysics reports/28, 2021-12 - Transcriptome analysis of gravitational effects on mouse skeletal muscles under microgravity and artificial 1 g onboard environment
Okada Risa; Fujita Shin-Ichiro; Suzuki Riku; Hayashi Tak...
Scientific reports/11, 2021-04 - Mathematical analysis of the effect of portal vein cells on biliary epithelial cell differentiation through the Delta-Notch signaling pathway
Yoshihara Masaharu; Nishino Teppei; Yadav Manoj Kumar; Ku...
BMC Research Notes/14, 2021-06 - EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice
Osawa Yuki; Murata Kazuya; Usui Miho; Kuba Yumeno; Le Ho...
eLife/10, 2021-05 - c-MAF deletion in adult C57BL/6J mice induces cataract formation and abnormal differentiation of lens fiber cells
Fujino Mitsunori; Tagami Asuka; Ojima Masami; Mizuno ...
Experimental animals/69(2)/pp.242-249, 2020-04 - An Inducible Diabetes Mellitus Murine Model Based on MafB Conditional Knockout under MafA-Deficient Condition
Deng Zhaobin; Matsumoto Yuka; Kuno Akihiro; Ojima Mas...
International journal of molecular sciences/21(16), 2020-08 - Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues
Susaki Etsuo A.; Shimizu Chika; Kuno Akihiro; Tainaka ...
NATURE COMMUNICATIONS/11(1), 2020-04 - Transcription factor MafB in podocytes protects against the development of focal segmental glomerulosclerosis
Usui Toshiaki; Morito Naoki; Shawki Hossam H; Sato Yo...
Kidney international/98(2)/pp.391-403, 2020-04 - Uncovering the role of MAFB in glucagon production and secretion in pancreatic α-cells using a new α-cell-specific Mafb conditional knockout mouse model
Chang Yu-Hsin; Katoh Megumi C; Abdellatif Ahmed M; Xiafuk...
Experimental animals/69(2)/pp.178-188, 2019-12 - MafB is important for pancreatic β-cell maintenance under a MafA deficient condition
Xiafukaiti Gulibaikelamu; Maimaiti Shayida; Ogata Kiyohi...
Molecular and cellular biology/39(17), 2019-06 - EFCAB2 is a novel calcium-binding protein in mouse testis and sperm
Shawki Hossam H; Ishikawa-Yamauchi Yu; Kawashima Akihiro...
PloS one/14(4), 2019-04 - KOnezumi: a web application for automating gene disruption strategies to generate knockout mice
Kuno Akihiro; Mizuno Seiya; Takahashi Satoru
Bioinformatics (Oxford, England)/35(18)/pp.3479-3481, 2019-02 - more...
- A universal method for generating knockout mice in multiple genetic backgrounds using zygote electroporation
- Conference, etc.
- 敵対的生成ネットワークによる自在な発現特異性を有するプロモータ配列の設計
Yukai Takagi; Haruka Ozaki; Akihiro Kuno; Kotaro Saka...
2022年日本バイオインフォマティクス学会年会・第11回生命医薬情報学連合大会（IIBMP2022）/2022-09-13--2022-09-15 - Effectiveness of Imatinib Formcto Nephropathy
Usui Toshiaki; Morito Naoki; Ishibashi Shun; Gogoleva Na...
60th ERA Congress/2023-06-15--2023-06-18 - 速筋線維の形成に不可欠な新規制御因子である大Maf転写因子の機能解析
定木駿弥; 藤田 諒; 林 卓杜; 中村 綾乃; 岡村 結; 布施谷 清香; 濱田 理人; 蕨 栄治; 久野 朗広...
日本分子生物学会年会/2022-12 - 宇宙でのマウス長期飼育における骨格筋への影響
定木 駿弥; 岡田 理沙; 藤田 晋一郎; 鈴木 陸; 林 卓杜; 加藤 千尋; 金井 真帆; 布施谷 清香; 井...
第94回日本生化学会大会/2021-11-03 - DAJIN validates the multiallelic genome editing outcomes using machine learning-assisted long-read sequencing
久野 朗広
Informatics In Biology, Medicine and Pharmacology 2021/2021-09-27--2021-09-29 - 微小重力において引き起こされるヒラメ筋の可塑的変化の解析
林卓杜; 藤田 諒; 工藤崇; 岡田理沙; 藤田晋一郎; 全孝静; 濱田理人; 久野朗広; 芝大; 白川正輝; 村谷匡史; 蕨栄治; 鈴...
第7回日本筋学会学術集会/2021-12-11--2021-12-12 - MAFB変異疾患 (MCTO)モデルマウスのポドサイト障害に対するイマチニブの治療効果
臼井俊明; 森戸直記; 石橋駿; 西野哲平; 金井真帆; Natalia Gogoleva; 井上由理; 布施谷清香; 久野朗広...
第65回日本腎臓学会学術総会/2022-06-10--2022-06-12 - リプログラム因子のパイオニア因子としての機能と量依存性
西村 健; 久野 朗広; 久武 幸司
第21回日本再生医療学会総会/2022-03-17--2022-03-17 - 微小重力において引き起こされるヒラメ筋の可塑的変化の解析
林卓杜; 藤田 諒; 工藤崇; 岡田理沙; 藤田晋一郎; 全孝静; 濱田理人; 久野朗広; 芝大; 白川正輝; 村谷匡史; 蕨栄治; 鈴...
第7回日本筋学会学術集会/2021-12-11--2021-12-12 - Deep-learning based genotype identifier for genetically modified animals using long DNA sequencer
久野 朗広
Informatics In Biology, Medicine, and Pharmacology - Role of transcription factor MafB in adult-b-cells under MafA deficient condition.
Gulibaikelamu Xiafukaiti; Shayida Maimaiti; Kiyohito Oga...
第41回日本分子生物学会年会/2018-11-28--2018-11-30 - 微小重力環境下でのエピジェネティクスによる骨格筋制御因子の探索
坪内 鴻奈; 岡田 理沙; 鈴木 陸; 布施谷 清香; 林 卓杜; 中村 勇輝; 久野 朗広; 村谷 匡史; 高橋...
第41回日本分子生物学会年会/2018-11-28--2018-11-30 - コア１構造由来のムチン型糖鎖欠損腹腔常在マクロファージはアポトー シス細胞のクリアランスが不完全となる
鈴木 陸; 涌井 宏優; 布施谷 清香; 新保 未来; 岡田 理沙; 濱田 理人; 久野 朗広; 萩原 梢; 佐藤...
第37回 日本糖質学会年会/2018-08-28--2018-08-30
- 敵対的生成ネットワークによる自在な発現特異性を有するプロモータ配列の設計
- Teaching
2023-07 -- 2023-07 Practice of Human Physiology University of Tsukuba. 2023-10 -- 2024-02 Special Practice in Human Biology I University of Tsukuba. 2023-10 -- 2024-02 Research Planning and Development in Human Biology University of Tsukuba. 2023-04 -- 2023-08 Research Planning and Development in Human Biology University of Tsukuba. 2023-05 -- 2023-08 Human anatomy University of Tsukuba. 2023-07 -- 2023-08 Bioinfomatics University of Tsukuba. 2022-10 -- 2023-02 Basic Experiments in Human Biology University of Tsukuba. 2022-04 -- 2022-08 Basic Experiments in Human Biology University of Tsukuba. 2022-07 -- 2022-08 Practice of Human Physiology University of Tsukuba. 2022-10 -- 2023-02 Research Planning and Development in Human Biology University of Tsukuba. more... - Other educational activities
2022-04 -- 2024-03 医学群医学類クラス担任 筑波大学 - University Management
2020-04 -- (current) The student support committee in Ph.D. Program in Humanixs 2021-04 -- (current) The education committee in Ph.D. Program in Human Biology 2020-04 -- (current) The admissions and enrollment committee in Ph.D. Program in Human Biology 2020-04 -- (current) The student support committee in Ph.D. Program in Human Biology Vice chairperson
(Last updated: 2023-09-07)