藤山 知之(フジヤマ トモユキ)

所属

国際統合睡眠医科学研究機構

職名

助教

ORCID

0000-0001-6420-2283

性別

男性

科研費番号

00635089

URL

https://researchmap.jp/tfujiyama
http://sleepymouse.jp/

学外所属

米国Duke大学医学部細胞生物学科
国立研究開発法人国立精神・神経医療研究センター　神経研究所

研究課題

NALCNチャネルの機能変化を介した吸入麻酔薬耐性メカニズムの検討	2022 -- 2024	藤山 知之	日本学術振興会/挑戦的研究（萌芽）	6,500,000円
非選択的陽イオンチャネルNALCNによるレム睡眠制御の分子基盤の解明	2020 -- 2022	藤山 知之	日本学術振興会/基盤研究(B)	17,550,000円

取得学位

2012-03	博士（医学）	京都大学

論文

• Evaluation of ET-2 physiology in the lung via the generation of a novel Edn-2 luminescent reporter mice
  Ryanto Gusty RIzky Tegu; Fujiyama Tomoyuki; Suzuki Yok...
  CLINICAL SCIENCE/138(1), 2024-05
• Kinase signalling in excitatory neurons regulates sleep quantity and depth
  Kim Staci J; Hotta-Hirashima Noriko; Asano Fuyuki; Kit...
  NATURE/612(7940)/pp.512-518, 2022-12-01
  
  PubMed
• Crucial role of TFAP2B in the nervous system for regulating NREM sleep
  Nakai Ayaka; Kashiwagi Mitsuaki; Fujiyama Tomoyuki; Iw...
  MOLECULAR BRAIN/17(1)/p.13, 2024-02-27
  
  PubMed
• Crucial role of TFAP2B in the nervous system for regulating NREM sleep
  Nakai Ayaka; Kashiwagi Mitsuaki; Fujiyama Tomoyuki; Iw...
  Molecular brain/17(1)/p.13, 2024-02-27
  
  PubMed
• SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice
  Asano Fuyuki; Kim Staci J; Fujiyama Tomoyuki; Miyoshi ...
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA/120(11), 2023-03-14
  
  PubMed
• Kinase signalling in excitatory neurons regulates sleep quantity and depth
  Kim Staci J; Hotta-Hirashima Noriko; Asano Fuyuki; Kit...
  NATURE/612(7940)/pp.512-518, 2022-12-01
  
  PubMed
• The Role of Reproductive Hormones in Sex Differences in Sleep Homeostasis and Arousal Response in Mice
  Choi Jinhwan; Kim Staci J.; Fujiyama Tomoyuki; Miyoshi...
  FRONTIERS IN NEUROSCIENCE/15, 2021-09
• An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension
  Ryanto Gusty R. T.; Ikeda Koji; Miyagawa Kazuya; Tu L...
  NATURE COMMUNICATIONS/12(1), 2021-03
• Efficient induction of proximity-dependent labeling by biotin feeding in BMAL1-BioID knock-in mice
  Murata Kazuya; Mimura Asuka; Suzuki Hayate; Mikami Na...
  Journal of biochemistry/170(4)/pp.453-461, 2021-05
  
  PubMed
• Induction of Mutant Sik3(Sleepy) Allele in Neurons in Late Infancy Increases Sleep Need
  Iwasaki Kanako; Fujiyama Tomoyuki; Nakata Shinya; Park M...
  The Journal of neuroscience : the official journal of the Society for Neuroscience/41(12)/pp.2733-2746, 2021-02
  
  PubMed
• Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β
  Nakai Ayaka; Fujiyama Tomoyuki; Nagata Nanae; Kashiwag...
  Genetics/216(3)/pp.753-764, 2020-09
  
  PubMed
• Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need
  Park Minjeong; Miyoshi Chika; Fujiyama Tomoyuki; Kakiz...
  SCIENTIFIC REPORTS/10(1), 2020-05
  
  PubMed
• Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1
  Fujiyama Tomoyuki; Yamada Mayumi; Terao Mami; Terashim...
  Development (Cambridge, England)/136(12)/pp.2049-2058, 2009-06-01
  
  PubMed
• Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain
  Fujiyama Tomoyuki; Miyashita Satoshi; Tsuneoka Yousuke...
  Cell reports/24(1)/pp.79-94, 2018-07
  
  PubMed Tsukuba Repository
• Quantitative phosphoproteomic analysis of the molecular substrates of sleep need
  Wang Zhiqiang; Ma Jing; Miyoshi Chika; Li Yuxin; Sato...
  Nature/558(7710)/pp.435-439, 2018-06
  
  PubMed
• Forward-genetics analysis of sleep in randomly mutagenized mice
  Funato Hiromasa; Miyoshi Chika; Fujiyama Tomoyuki; Kan...
  NATURE/539(7629)/pp.378-383, 2016-11
  
  PubMed
• Mice lacking cerebellar cortex and related structures show a decrease in slow-wave activity with normal non-REM sleep amount and sleep homeostasis.
  Fujiyama Tomoyuki; Takenaka Henri; Asano Fuyuki; Miyan...
  FRONTIERS IN BEHAVIORAL NEUROSCIENCE/16/pp.910461-910461, 2022/5
  
  PubMed
• Ptf1a inactivation in adult pancreatic acinar cells causes apoptosis through activation of the endoplasmic reticulum stress pathway
  Sakikubo Morito; Furuyama Kenichiro; Horiguchi Masashi...
  SCIENTIFIC REPORTS/8, 2018-10
  
  PubMed
• A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice
  Honda Takato; Fujiyama Tomoyuki; Miyoshi Chika; Ikkyu ...
  Proceedings of the National Academy of Sciences of the United States of America/115(41)/pp.10458-10463, 2018-09
  
  PubMed

会議発表等

• ムーンショット：睡眠基礎研究の最前線
  柳沢 正史; 藤山知之; 史蕭逸; 安垣進之助; Roy Koustav
  日本睡眠学会第48回定期学術集会/2024/07/19

担当授業科目

2022-07 -- (現在)	令和4年度サマーリサーチプログラムSRP2022教員担当	筑波大学HBP
2022-07 -- 2022-08	令和4年度　バイオサイエンストピック　-EC32041-	筑波大学生物資源

(最終更新日: 2024-09-18)